Clinical Core

临床核心

基本信息

批准号：
10203770
负责人：
Aimee Pierce
金额：
$ 99.66万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10203770
关键词：
African American Aged, 80 and over Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Attention Behavior monitoring Biological Biological Markers Blood Clinic Clinical Clinical Research Clinical Trials Clinical assessments Collaborations Communities Computers Conduct Clinical Trials DNA Data Dementia Development Disease Education Elderly Ensure Environment Fostering Goals Health Home Image Individual Infrastructure Investigator-Initiated Research Knowledge Liquid substance Magnetic Resonance Imaging Measures Methods Monitor Octogenarian Oregon Outcome Participant Peripheral Pharmacology Phase Population Positron-Emission Tomography Procedures Research Research Activity Research Design Research Personnel Research Subjects Resources Science Scientist Severity of illness Sister Sleep Specimen Standardization Technology Telemedicine Testing Time Tissues Training Training and Education Work aging brain aging in place base brain tissue career cohort collaborative environment community clinic computer generated cooperative study data acquisition data management data sharing dementia risk digital education research follow-up high risk improved innovation interest neuroimaging neuroimaging marker neuropathology novel outreach pre-clinical prevent programs recruit remote monitoring repository sensor statistics tool volunteer

项目摘要

Project Summary: Clinical Core The Clinical Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to ADRD; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Clinical Core is organized facilitate the study of transitions from normative function to preclinical and early Alzheimer’s disease (AD), as well as providing the core infrastructure to facilitate developing needed treatments to prevent or moderate these transitions across the spectrum of disease severity. It is additionally the responsibility of this core to provide the infrastructure for a wide array of innovative and evolving research activities ranging from providing clinical study design expertise (in concert with the Data Management and Statistics Core) to support of treatment studies. In being continually responsive to its research community, the Clinical Core has developed focused special units to further enhance the provision of leading edge imaging, telemedicine and clinical trials conduct. Within this context the Clinic Core Specific Aims are to: 1. Identify, recruit, and longitudinally assess individuals necessary to provide a ready pool of well- characterized subjects for research emphasizing the presymptomatic to early AD spectrum. 2. Include the underserved African American older adult population in this research enterprise through an on- going coordinated Satellite Program, the African American Dementia Aging & Project (AADAPt). 3. Coordinate and assist in concert with its sister Cores, tissue, biospecimen (blood, CSF, DNA), neuroimaging, and digital biomarker data acquisition to facilitate research incorporating new and developing tools and methods in such rapidly progressing fields as neuroimaging, biomarkers, remote monitoring, telemedicine, and clinical trials. 4. Support investigator-initiated research pertaining to the dementias and foster research collaboration and data sharing both regionally and nationally.

项目摘要：临床核心临床核心旨在支持 OADRC 5 个总体目标的总体具体目标：1) 通过以下方式促进和维持 AD 及相关痴呆症 (ADRD) 的创新研究和发现支持丰富的协作环境的组织基础设施；2）将资源集中到特定的领域；重点领域：临床前痴呆和强调最古老标志的疾病活动；通过外周生物标志物、神经影像学和持续在家中的研究捕获有意义的变化行为监测；大脑衰老和晚年痴呆的神经病理学；新疗法的新测试；改善有关痴呆症的教育和知识；3）通过以下方式提供支持科学的材料；明确的研究参与者、生物标本、脑组织、数据提供和分析；4) 为与 ADRD 相关的国家研究共享做出贡献；5) 提供场所和机制新科学家的教育和培训，以及关键利益相关者的教育和信息通报。 OADRC 的临床核心旨在促进从规范功能到临床前的过渡研究和早期阿尔茨海默病 (AD)，以及提供核心基础设施以促进开发所需的此外，还需要采取治疗措施来预防或缓和疾病严重程度的这些转变。该核心的责任是为广泛的创新和不断发展的研究提供基础设施活动范围包括提供临床研究设计专业知识（与数据管理和统计核心）以支持治疗研究，不断响应其研究界，临床核心开发了重点特殊单位，以进一步增强领先成像的提供，在此背景下，诊所的核心具体目标是： 1. 识别、招募和纵向评估所需的个人，以提供现成的优秀人才库强调从症状前到早期 AD 谱的研究对象的特征。 2. 通过一项持续性的研究，将服务不足的非裔美国老年人纳入这项研究事业。协调卫星计划，非裔美国人痴呆症老龄化与项目 (AADAPt)。 3. 与其姊妹核心、组织、生物样本（血液、脑脊液、DNA）协调和协助，神经影像和生物标记数字数据采集，以促进结合新的和在神经影像、生物标志物、远程技术等快速发展的领域开发工具和方法监测、远程医疗和临床试验。 4. 支持研究者发起的有关痴呆症的研究并促进研究合作和区域和国家范围内的数据共享。