Administrative Core

行政核心

基本信息

批准号：
10641024
负责人：
JEFFREY A KAYE
金额：
$ 48.5万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641024
关键词：
African American Aged, 80 and over Aging Alzheimer&apos s Disease Animal Welfare Area Behavior monitoring Biological Biological Assay Biological Markers Clinical Clinical Research Clinical Trials Clinical Trials Unit Clinical assessments Collaborations Communities Community Participation Data Dementia Development Disease Education Education and Outreach Elderly Ensure Event Fostering Goals Home Image Individual Infrastructure Institution Knowledge Lead Left Link Monitor Oregon Participant Peripheral Policies Productivity Research Research Design Resources Role Science Scientist Side Sister Specimen Standardization Structure Technology Testing Time Tissues Training and Education United States National Institutes of Health Universities Work aging brain brain tissue cohort collaborative environment cooperative study data management data sharing education research follow-up high standard human subject improved innovation neuroimaging neuropathology novel outreach pre-clinical preservation programs quality assurance recruit repository statistics

项目摘要

Project Summary: Administrative Core The Administrative Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Administrative Core provides oversight, management and quality assurance for the activities of the Center. It acts as the lead unit in strengthening and improving existing links between scientific and appropriate lay community leaders and organizations both locally and nationally. It is responsible for fostering new and innovative research relevant to brain aging and the dementias wherever and whenever possible. The Administrative Core Specific Aims are to: 1. Coordinate and integrate the individual core units and resources of the OADRC and their interactions with each other, as well as with individual scientists, clinicians, educators and the community. 2. Oversee and monitor the directions and interactions of the Center, setting relevant goals and optimizing resource utilization, guided by input from the scientific and lay communities. 3. Perform ongoing, regular review of progress. Ensure each unit within the OADRC performs to standards of highest quality and productivity while operating in strict compliance with human subjects, animal welfare, scientific integrity, and financial policy requirements of the university and NIH. 4. Provide a structure and forum to foster and develop new and innovative research in brain aging and the dementias, including the OADRC Developmental Projects. 5. Facilitate collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease Research Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the Alzheimer’s Clinical Trials Consortium, the National Centralized Repository for Alzheimer’s Disease and other relevant outside research groups.

项目概要：行政核心行政核心旨在支持 OADRC 5 个总体目标的总体具体目标：1) 通过以下方式促进和维持 AD 及相关痴呆症 (ADRD) 的创新研究和发现支持丰富的协作环境的组织基础设施；2）将资源集中到特定的领域；重点领域：临床前痴呆和强调最古老标志的疾病活动；通过外周生物标志物、神经影像学和持续在家中的研究捕获有意义的变化行为监测；大脑衰老和晚年痴呆的神经病理学；新疗法的新测试；改善有关痴呆症的教育和知识；3）通过以下方式提供支持科学的材料；明确的研究参与者、生物标本、脑组织、数据提供和分析；4) 为与 AD 和相关疾病相关的国家研究共享做出贡献；5) 提供场地和新科学家的教育和培训机制，以及主要利益相关者的教育和信息通报机制。 OADRC 的行政核心为以下机构的活动提供监督、管理和质量保证：该中心是加强和改善科学与技术之间现有联系的牵头单位。它负责培养当地和国家的适当的非专业社区领袖和组织。无论何时何地，与大脑衰老和痴呆症相关的新的和创新的研究。行政核心的具体目标是： 1.协调和整合OADRC的各个核心单位和资源及其与OADRC的互动彼此之间，以及科学家个人、教育工作者、教育工作者和社区之间的关系。 2. 监督和监控中心的方向和互动，制定相关目标并优化资源利用，以科学界和非专业界的投入为指导。 3. 确保 OADRC 内的每个单位都按照以下标准执行进展情况。最高的质量和生产力，同时严格遵守人类受试者、动物福利、科学诚信以及大学和 NIH 的财务政策要求。 4. 提供一个结构和论坛来促进和发展脑衰老和脑衰老方面的新的和创新性的研究痴呆症，包括 OADRC 发展项目。 5. 促进与其他阿尔茨海默病患者的合作研究、科学互动和数据共享传输疾病研究中心、国家阿尔茨海默病协调中心、阿尔茨海默病合作研究单位、阿尔茨海默病临床试验联盟、国家集中存储库阿尔茨海默病和其他相关的外部研究小组。