U2C Administrative Core

U2C 管理核心

• 批准号: 10201602
• 负责人: Dean Paul Jones
• 金额: $ 6.28万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201602
• 关键词: Big Data; Biochemical; Cells; Chemicals; Collaborations; Communication; Communities; Complement; Data; Databases; Dedications; Development; Disease; Dissociation; Effectiveness; Environmental Health; Goals; Health; Human; Infrastructure; Ions; Knowledge; Laboratories; Lead; Leadership; Life; Maintenance; Movement; National Institute of Environmental Health Sciences; Pattern; Pharmacology; Research; Research Personnel; Resolution; Role; Sampling; Schedule; Science; Services; Structure; Support System; System; Testing; Time; Training; Universities; Work; Xenobiotic Metabolism; Xenobiotics; adduct; career development; design; environmental chemical; experience; flexibility; improved; innovation; laboratory facility; meetings; metabolomics; outreach; professor; programs; skills; success; tool; tool development; usability

Administrative Core Project Summary The Administrative Core serves critical leadership, organizational and identity roles for the Compound Identity Discovery Core (CIDC) at Emory University. Dr. Jones will serve as Core Director and maintain overall organization through regular interactions with MPIs Dr Miller, Dr Morgan and Dr Li. Dr Jones has expertise in metabolomics and long-term scientific collaborations and academic interactions with other proven scientific leaders of the Core, Dr Miller and Dr Morgan. The Core is designed to maintain a high level of flexibility for Dr Morgan's leadership in the Experimental Core to develop arrays of cell systems for targeted xenobiotic biochemical transformation while at the same time coordinating this with Dr Li's development of computational systems to support high throughput chemical identification. The Core is further designed to complement central tool development goals with activities of the Metabolomics Consortium, support service for exposome- related metabolite identification and metabolomics training and career development. Dr Miller, Director of the NIEHS-supported HERCULES Human Exposome Research Center at Emory, will be Co-Director for Exposome Outreach and Exposome Metabolite Identification. Dr Morgan will be Co-Director for Metabolomics Training and Career Development. Together, these investigators bring a high degree of organization and management experience to the Emory CIDC. The goals of the Core are to 1) Provide leadership and guidance for the Emory CIDC. The Core will work to assure that the complementary group of Emory CIDC laboratories and facilities work efficiently as a team to assure success in development of compound identification tools for xenobiotic metabolites. 2) Assure progress of the Computational Core and Experimental Core in achieving their objectives. These cores are distinct but interdependent; the Administrative Core will work to assure that the Computational Core and the Experimental Core each achieve its goals, thereby helping assure the overall success in tool development. 3) Develop an infrastructure for servicing needs of the exposome research community in identification of environmental metabolites associated with disease. The Administrative Core will work with HERCULES Human Exposome Research Center to develop a structure to support real-life testing of xenobiotic metabolite identification tools to benefit stakeholders and improve design and usability. 4) Facilitate communication between the Emory CIDC and the Metabolomics Consortium leadership, other Metabolomics Consortium components and stakeholders. The Administrative Core will serve as the primary conduit for interaction with the Metabolomics Consortium and will support additional outreach, training and career development objectives. The combined expertise and leadership skills of the Administrative Core will assure that the Emory CIDC achieves its goals to develop powerful new chemical identification tools that are scalable to identify hundreds of thousands of metabolites of environmental chemicals and other components of the human exposome.

行政核心项目概要 管理核心为复合身份提供关键的领导、组织和身份角色 埃默里大学的发现核心 (CIDC)。琼斯博士将担任核心董事并维持整体 通过与 MPI 米勒博士、摩根博士和李博士定期互动来组织。琼斯博士拥有以下方面的专业知识： 代谢组学以及与其他经过验证的科学领域的长期科学合作和学术互动 核心领导人米勒博士和摩根博士。核心旨在保持博士的高度灵活性 摩根在实验核心领域的领导地位，致力于开发针对目标异生素的细胞系统阵列 生化转化，同时与李博士的计算发展相协调 系统支持高通量化学鉴定。该核心的进一步设计是为了补充 代谢组学联盟活动的中心工具开发目标，暴露组的支持服务 相关代谢物鉴定和代谢组学培训和职业发展。米勒博士，主任 NIEHS 支持的埃默里大学 HERCULES 人类暴露组研究中心将担任该中心的联合主任 暴露组外展和暴露组代谢物鉴定。摩根博士将担任代谢组学联合主任 培训和职业发展。这些调查人员共同带来了高度的组织和 埃默里 CIDC 的管理经验。核心的目标是 1) 提供领导和指导 埃默里大学 CIDC。核心将努力确保埃默里大学 CIDC 实验室的互补小组 和设施作为一个团队有效地工作，以确保成功开发化合物识别工具 外源代谢物。 2）确保计算核心和实验核心在实现目标方面取得进展 他们的目标。这些核心各不相同但又相互依赖；行政核心将努力确保 计算核心和实验核心各自实现其目标，从而有助于确保整体 工具开发的成功。 3) 开发满足暴露研究服务需求的基础设施 社区识别与疾病相关的环境代谢物。行政核心将 与 HERCULES 人类暴露组研究中心合作开发一种结构来支持现实生活中的测试 外源代谢物识别工具可以使利益相关者受益并改进设计和可用性。 4）促进 埃默里 CIDC 与代谢组学联盟领导层、其他代谢组学之间的沟通 联盟成员和利益相关者。行政核心将作为主要渠道 与代谢组学联盟互动，并将支持额外的外展、培训和职业生涯 发展目标。行政核心的综合专业知识和领导技能将确保 埃默里 CIDC 实现了开发强大的可扩展的新型化学品识别工具的目标 识别环境化学物质和其他成分的数十万种代谢物 人类暴露组。