ENVIRONMENTAL HEALTH SCIENCES

环境健康科学

• 批准号: 2153103
• 负责人: William G Thilly
• 金额: $ 113.96万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2153103
• 关键词: biomedical facility; environmental toxicology

The MIT Center for Environmental Health Sciences is a multidisciplinary research organization which has taken as its primary mission the discovery of the relationship between human exposure to environmental chemicals, mutation, and genetic diseases such as cancer and birth defects. The Center faculty are integrated in six multidisciplinary research programs which address the sources, environmental movement and genetic effects of chemicals borne to humans by food, air and water. One of these, the Superfund Basic Research Program, involves study of chemical exposure and genetic change in the population of the nearby Aberjona River Basin. This major effort began with four years of public outreach activities and which continue in a public education program to explain the basis, potential value and limitations of our studies in this community in which many of our faculty and staff reside. The MIT academic departments represented by Center faculty include Toxicology (7), Civil Engineering (7), Chemical Engineering (5), Mechanical Engineering (7), Chemistry (2), Biology (2) and Earth and Planetary Sciences (1). Joining these several disciplines together are the shared Core Laboratories in Analytical Chemistry and Toxicology which permit analysis, testing and identification of the most important human mutagens in complex environmental mixtures. Key technologies developed at the Center include means to measure and identify chemicals in human tissue proteins and measurement of mutations and mutational spectra in human cells or tissues. These technologies now drive a transmutation of present core facilities and faculty research toward direct measurement of chemicals and patterns of genetic changes in human cells and tissues. Through these studies we hope to fulfill our primary mission and make a contribution to public health that will justify public support of work.

麻省理工学院环境健康科学中心是多学科 研究组织已将其作为其主要使命 发现人类接触环境之间的关系 化学物质，突变和遗传疾病，例如癌症和出生 缺陷。 中心教师融入了六个多学科 涉及来源，环境运动和 食物，空气和水对人类承担的化学物质的遗传作用。 一 其中，超级基础研究计划涉及研究 附近人群的化学暴露和遗传变化 阿伯乔纳河流域。 这项重大努力始于四年的公众 外展活动，并继续进行公共教育计划 解释我们研究的基础，潜在价值和局限性 我们许多教职员工居住的社区。 由中心教师代表的麻省理工学院学术部门包括 毒理学（7），土木工程（7），化学工程（5）， 机械工程（7），化学（2），生物学（2）和地球以及 行星科学（1）。 加入这几个学科是 分析化学和毒理学中共享的核心实验室，这些实验室 允许分析最重要的人 复杂的环境混合物中的诱变剂。 开发了关键技术 中心包括测量和识别人类化学物质的方法 组织蛋白以及突变和突变光谱的测量 人类细胞或组织。 这些技术现在推动了 目前的核心设施和教师研究直接测量 人类细胞和组织中遗传变化的化学和模式。 通过这些研究，我们希望实现我们的主要任务，并做一个 对公共卫生的贡献，这将证明公众对工作的支持是合理的。