Southwest Health Equity Research Collaborative

西南健康公平研究合作组织

• 批准号: 10198142
• 负责人: Julie Ann Baldwin
• 金额: $ 11.95万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198142
• 关键词: Address; Affect; American Indians; Area; Arizona; Attention; Basic Science; Behavior Therapy; Behavioral Research; Behavioral Sciences; Biological; Biomedical Research; Cells; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Communities; Community Health; Complement component C1; Computing Methodologies; County; Data Analyses; Data Collection; Data Security; Dental caries; Development; Disease; Ensure; Environment; Environmental Health; Environmental Pollution; Environmental Risk Factor; Extramural Activities; Federally Qualified Health Center; Feedback; Fostering; Funding; Genotype; Goals; Health; Health Sciences; Hispanics; Hospitals; Individual; Infection; Informatics; Infrastructure; Institution; Intervention; Knowledge; Laboratories; Lead; Leadership; Logistics; Mentors; Methodology; Minority; Modeling; NCI Scholars Program; Needs Assessment; Pathogenicity; Pilot Projects; Policies; Population; Population Heterogeneity; Postdoctoral Fellow; Premalignant Cell; Prevalence; Productivity; Reovirus; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Role; Schools; Science; Scientific Inquiry; Social Interaction; Southwestern United States; Staphylococcus aureus; Strategic Planning; Streptococcus mutans; Testing; Time; United States Indian Health Service; United States National Institutes of Health; Work; authority; base; behavioral health; cancer cell; cancer therapy; career; chronic wound; data quality; disease transmission; early childhood; empowered; evidence base; faculty support; fibrillogenesis; health disparity; health equity; health goals; improved; innovation; member; minority health; mortality; novel; oral microbiome; programs; recruit; resilience; senior faculty; theories; transmission process; tribal health; tumor

PROJECT SUMMARY The overall goal of SHERC is to increase basic biomedical, clinical, and behavioral research at NAU to address health disparities among diverse populations of the Southwestern United States. In the first 5 years, we will increase research capacity in the areas of environmental and community health, building on a strong research base at NAU. Over time, SHERC will work closely with community partners to expand capacity to address health disparities in chronic and infectious diseases, as well as high-priority behavioral health conditions, as determined by community partners. SHERC consists of five cores that all interact synergistically. Each of the SHERC cores provides a clear opportunity for innovation individually; in combination, they demonstrate significant impact in innovation. The Administrative Core combines evidence-based organizational theory with a tested but novel use of a “continuous improvement” model of program assessment and feedback. The Research Infrastructure Core will focus on infrastructure improvement for the SHERC basic research, informatics, clinical, and community engaged science programs. In addition, it will take a leadership role in improving the interdisciplinary science efforts in biomedical, clinical, and community health science initiatives throughout NAU. The Investigator Development Core will support the development of early career investigators in basic biomedical, behavioral, and clinical sciences at NAU through two innovative programs: a Pilot Project Program (PPP) to support faculty and a Postdoctoral Scholar Program (PSP) to support and mentor postdoctoral researchers. The Community Engagement Core uses an innovative four- direction Framework for Inquiry and Action that will represent the shared and distinct determinants of health in Arizona. The five Research Projects include the following innovative studies: Pearson's research project will define and contrast S. aureus carriage and circulating genotypes with clinical genotypes and infection prevalence to better understand how social interactions impact transmission. Kellar and Propper seek to enhance current research on the relationship between environmental contaminants and clinical complications such as non-healing chronic wounds. The Varadaraj study will exploit a cellular adaptation in tumors, to determine whether altering fibrillogenesis in such states will switch premalignant cells to malignant cells and whether preinvasive cells would become invasive. Naren's study has the potential to improve and extend reovirus based cancer therapies. Fofonav's study may identify individuals with an oral microbiome that is more susceptible to early childhood caries (ECC) or individuals with particularly pathogenic strains of S. mutans and S. sobrinus.

项目概要 SHERC 的总体目标是加强 NAU 的基础生物医学、临床和行为研究，以 解决美国西南部不同人群之间的健康差异。 我们将在强大的基础上提高环境和社区健康领域的研究能力 随着时间的推移，SHERC 将与社区合作伙伴密切合作，扩大能力 解决慢性病和传染病方面的健康差异，以及高度优先的行为健康 由社区合作伙伴确定的条件，SHERC 由五个核心组成，所有这些核心都协同作用。 每个 SHERC 核心都单独提供了明显的创新机会； 展现出对创新的重大影响。 组织理论，经过测试但新颖地使用了项目评估的“持续改进”模型 研究基础设施核心将重点关注 SHERC 的基础设施改进。 此外，还需要基础研究、信息学、临床和社区参与的科学项目。 在改善生物医学、临床和社区健康领域的跨学科科学工作方面发挥领导作用 科学贯穿倡议 NAU 研究者发展核心将支持早期研究的发展。 通过两个创新项目，在 NAU 培养基础生物医学、行为和临床科学领域的职业研究者 计划：支持教师的试点项目计划（PPP）和博士后学者计划（PSP） 支持和指导博士后研究人员。社区参与核心采用创新的四- 调查和行动的方向框架将代表健康问题的共同和独特的决定因素 亚利桑那州。这五个研究项目包括以下创新研究： 皮尔逊的研究项目将 定义金黄色葡萄球菌携带和循环基因型与临床基因型和感染并进行对比 Kellar 和 Propper 试图通过研究流行率来更好地了解社交互动如何影响传播。 加强当前环境污染物与临床并发症之间关系的研究 Varadaraj 研究将利用肿瘤的细胞适应，例如无法愈合的慢性伤口。 确定改变这种状态下的原纤维形成是否会将癌前细胞转变为恶性细胞，以及 侵袭前细胞是否会变得具有侵袭性。 纳伦的研究 有潜力改进和扩展 基于呼肠孤病毒的癌症疗法。 福福纳夫的研究 可能会识别出口腔微生物群更丰富的个体 对早期儿童携带者 (ECC) 或具有特殊致病性变形链球菌菌株的个体易感， S. sobrinus。