ELECTROCHEMICAL DIALYSATE REGENERATION

电化学透析液再生

• 批准号: 2143814
• 负责人: Sidney K. Wolfson
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2143814
• 关键词: ammonia; bioengineering /biomedical engineering; biomedical equipment development; dialysis therapy; electrochemistry; home health care; kidney disorder

DESCRIPTION: (Adapted from investigator's abstract) End stage renal disease (ESRD) is a medically, socially, and economically devastating reality for over 172,000 patients in the United States. The average per capita cost of treatment was $35,600, for an aggregate total of $5.4 billion in 1988. Most patients receive treatment in a dialysis center setting. The cost for home-care patients is approximately half that for dialysis center patients. In addition to substantially lowering costs for ESRD treatment, a portable artificial kidney will improve quality of life for many patients by freeing them from a center dependent lifestyle. The ultimate goal of this research program is development of a truly portable electrochemical artificial kidney which uses a minimal amount of dialysate, about 5 L per hemodialysis session, in the maintenance of patients with end stage renal disease (ESRD). In principle, the proposed artificial kidney requires little more than an electrical outlet and tap-water source for its operation. The specific objective of this proposal is development and performance validation of the electrochemical dialysate regeneration system that will be used in the portable artificial kidney, specific research objectives include: determination of breakthrough curves and appropriate size for a clinical scale zeolitic ammonia absorption column; construction of a clinical-scale electrochemical dialysate regeneration system comprised of an electrochemical oxidation reactor and ammonia absorption column; demonstration of the efficacy of the system in removal of such waste metabolites as urea, uric acid, creatinine from dialysate; demonstration of the efficacy of the system in conjunction with in vitro dialysis with limited quantities (about 5 L) of recycled dialysate; monitoring of hemodialysis backexchange of reaction products to the in vitro simulated patient; and determination of the nature of such products. The specific aims will be accomplished through a laboratory investigation using electrochemistry, wet chemistry, and dialysis apparatus. Statistically designed experiments to maximize information for effort expended will be used. The major results from successful completion of this proposal are demonstration that a compact electrochemical approach to dialysate regeneration for use in portable hemodialysis applications is feasible and demonstration that zeolitic ammonia absorption is an alternative, potentially superior approach to the commonly used zirconium oxide/zirconium phosphate ion exchange for ammonia removal in dialysate regeneration.

描述：（根据调查员的摘要改编）末期肾脏 疾病（ESRD）是一种医学，社会和经济上的毁灭性的 美国超过172,000名患者的现实。 平均值 Capita的治疗费用为35,600美元，总计$ 5.4 1988年十亿。大多数患者在透析中心接受治疗 环境。 家庭保健患者的费用约为 透析中心患者。 除了大幅降低成本 ESRD治疗，便携式人造肾脏将改善生活质量 对于许多患者，通过将他们从中心依赖的生活方式释放出来。 该研究计划的最终目标是开发真正的 便携式电化学人工肾脏，使用最少的 透析液，每次血液透析疗程约5升，以维持 终阶段肾脏疾病（ESRD）的患者。 原则上，提议 人造肾脏只需要一个电源出口和 Tap-Water源用于其操作。 该提案的具体目标是发展和绩效 验证电化学透析液再生系统 用于便携式人工肾脏，特定的研究目标 包括：确定突破性曲线和适当的大小 临床量表沸石吸收柱；构建 临床规模的电化学透析液再生系统由 电化学氧化反应器和氨吸收柱； 证明该系统消除此类废物的功效 代谢物为尿素，尿酸，肌酐来自透析；示范 系统的功效与体外透析 有限数量（约5升）的可回收透析液；监视 反应产物对体外模拟的反应产物血液透析 病人;并确定此类产品的性质。 具体 目标将通过实验室调查来实现 电化学，湿化学和透析设备。 统计上 设计实验以最大程度地提高信息以进行花费的努力 用过的。 该提案成功完成的主要结果是 证明透析液的紧凑电化学方法 用于便携式血液透析应用的再生是可行的， 证明吸收沸石是一种替代品 常用锆的潜在卓越方法 氧化物/锆磷酸离子交换以透析液中的氨去除氨 再生。

项目成果

Ammonia transport across hydrophobic membranes. Application to dialysate regeneration.

氨穿过疏水膜运输。

• 发表时间: 1995
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Patzer2nd,JF;Yao,SJ;WolfsonJr,S
• 通讯作者: WolfsonJr,S