ELECTROCHEMICAL DIALYSATE REGENERATION

电化学透析液再生

• 批准号: 2143814
• 负责人: Sidney K. Wolfson
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1995-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2143814
• 关键词: ammonia; bioengineering /biomedical engineering; biomedical equipment development; dialysis therapy; electrochemistry; home health care; kidney disorder

DESCRIPTION: (Adapted from investigator's abstract) End stage renal disease (ESRD) is a medically, socially, and economically devastating reality for over 172,000 patients in the United States. The average per capita cost of treatment was $35,600, for an aggregate total of $5.4 billion in 1988. Most patients receive treatment in a dialysis center setting. The cost for home-care patients is approximately half that for dialysis center patients. In addition to substantially lowering costs for ESRD treatment, a portable artificial kidney will improve quality of life for many patients by freeing them from a center dependent lifestyle. The ultimate goal of this research program is development of a truly portable electrochemical artificial kidney which uses a minimal amount of dialysate, about 5 L per hemodialysis session, in the maintenance of patients with end stage renal disease (ESRD). In principle, the proposed artificial kidney requires little more than an electrical outlet and tap-water source for its operation. The specific objective of this proposal is development and performance validation of the electrochemical dialysate regeneration system that will be used in the portable artificial kidney, specific research objectives include: determination of breakthrough curves and appropriate size for a clinical scale zeolitic ammonia absorption column; construction of a clinical-scale electrochemical dialysate regeneration system comprised of an electrochemical oxidation reactor and ammonia absorption column; demonstration of the efficacy of the system in removal of such waste metabolites as urea, uric acid, creatinine from dialysate; demonstration of the efficacy of the system in conjunction with in vitro dialysis with limited quantities (about 5 L) of recycled dialysate; monitoring of hemodialysis backexchange of reaction products to the in vitro simulated patient; and determination of the nature of such products. The specific aims will be accomplished through a laboratory investigation using electrochemistry, wet chemistry, and dialysis apparatus. Statistically designed experiments to maximize information for effort expended will be used. The major results from successful completion of this proposal are demonstration that a compact electrochemical approach to dialysate regeneration for use in portable hemodialysis applications is feasible and demonstration that zeolitic ammonia absorption is an alternative, potentially superior approach to the commonly used zirconium oxide/zirconium phosphate ion exchange for ammonia removal in dialysate regeneration.

描述：（改编自研究者摘要）终末期肾病 疾病（ESRD）是一种对医学、社会和经济具有破坏性的疾病 美国超过 172,000 名患者的现实情况。 平均每 人均治疗费用为 35,600 美元，总计 5.4 美元 1988 年 10 亿美元。大多数患者在透析中心接受治疗 环境。 家庭护理患者的费用大约是普通患者的一半 透析中心的患者。 除了大幅降低成本外 ESRD 治疗，便携式人工肾将改善生活质量 对于许多患者来说，将他们从依赖中心的生活方式中解放出来。 该研究计划的最终目标是开发一个真正的 便携式电化学人工肾，使用最少量的 透析液，每次血液透析约 5 L，用于维持 患有终末期肾病（ESRD）的患者。 原则上，拟议的 人工肾只需要一个电源插座 其运行的自来水源。 该提案的具体目标是开发和性能 电化学透析液再生系统的验证 用于便携式人工肾，具体研究目标 包括：确定突破曲线和适当的尺寸 临床规模沸石氨吸收塔；建造一个 临床规模电化学透析液再生系统包括 电化学氧化反应器和氨吸收塔； 展示系统清除此类废物的功效 透析液中的尿素、尿酸、肌酐等代谢物；示范 该系统与体外透析相结合的功效 有限数量（约 5 L）的回收透析液；监测 血液透析反应产物与体外模拟物的反交换 病人;并确定此类产品的性质。 具体的 将通过实验室调查来实现目标 电化学、湿化学和透析装置。 统计上 设计实验以最大限度地利用所付出的努力的信息 用过的。 成功完成本提案的主要成果是 证明一种紧凑的电化学方法处理透析液 用于便携式血液透析应用的再生是可行的并且 证明沸石氨吸收是一种替代方案， 可能优于常用锆的方法 氧化物/磷酸锆离子交换用于去除透析液中的氨 再生。

项目成果

Ammonia transport across hydrophobic membranes. Application to dialysate regeneration.

氨穿过疏水膜运输。

• 发表时间: 1995
• 期刊: ASAIO journal (American Society for Artificial Internal Organs : 1992)
• 作者: Patzer2nd,JF;Yao,SJ;WolfsonJr,S
• 通讯作者: WolfsonJr,S