Disparities in Exposure and Health Effects of Multiple Environmental Stressors Across the Life Course

生命历程中多种环境压力因素的暴露和健康影响的差异

基本信息

批准号：
10175523
负责人：
Francine Laden
金额：
$ 22.11万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-24 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10175523
关键词：
Address African American Air Pollution Area Birth COVID-19 COVID-19 pandemic Cardiovascular system Cessation of life Characteristics Chemicals Childhood Cities Communicable Diseases Communities Data Data Set Databases Disease Outbreaks Environment Environmental Exposure Environmental Health Epidemiology Ethnic Origin Future Geography Growth Health Health care facility High Prevalence Hispanics Home environment Hospitalization Hot Spot Housing Incidence Individual Infection Intervention Knowledge Leadership Life Cycle Stages Link Long-Term Care Low income Masks Massachusetts Methods Minority Neighborhoods New Jersey New York Not Hispanic or Latino Occupational Exposure Outcome Pattern Perception Persons Physical environment Plant Roots Play Policies Population Prevalence Prevention strategy Public Health Race Recommendation Research Research Project Grants Risk Assessment Risk Factors Role Science Severities Severity of illness Social Environment Techniques Temperature Time United States Vulnerable Populations Work adverse outcome base built environment comorbidity density disparity reduction environmental stressor ethnic minority population geographic difference health disparity health economics infection rate minority communities mortality novel pandemic disease population health predictive modeling racial and ethnic racial and ethnic disparities segregation simulation social social stressor sociodemographics spatiotemporal stressor temporal measurement transmission process

项目摘要

PROJECT SUMMARY The primary objective of our Center is to understand and reduce environmental health disparities (EHDs) by conducting three fully-integrated research projects applying novel methods in epidemiology, exposure science, and cumulative risk assessment, with strong community engagement across the Center. The Center emphasizes multiple health outcomes across the life course with evidence for EHDs (birth outcomes, childhood growth rates, and cardiovascular mortality), in Massachusetts and within two low-income majority-minority communities (Chelsea and Dorchester). The influence of housing and the neighborhood environment on multiple exposures and health outcomes are emphasized throughout the Center. Within Project 3, we use novel geospatial data and simulation techniques to provide an extensive and highly resolved set of chemical and non-chemical stressor exposures, including spatially-resolved air pollution and temperature data generated in Project 1. In this supplement, we will leverage our Project 3 geospatial database of numerous social, housing, demographic, and environmental exposures across Massachusetts to evaluate racial/ethnic disparities in COVID-19 cases, hospitalizations, and deaths. Our geospatial vulnerability data will be linked with individual-level COVID-19 data with address-level geocodes and daily temporal resolution, provided by the Massachusetts Department of Public Health. We will identify vulnerability factors associated with disparities in incidence and severity of COVID-19 infection across cities and towns in Massachusetts, modeling predictors of case incidence per 10,000 persons and hospitalizations per 10,000 persons by city/town over time. We will also apply novel methods to characterize spatiotemporal clustering, allowing us to determine differences in spatiotemporal patterns of COVID-19 spread within and between cities/towns, including as a function of individual characteristics. Finally, we will examine differences in city/town-specific policies, implementation of state policy, and resident perception of public health recommendations, to determine if observed patterns can be explained in part by between-city differences. With these analyses we will identify COVID-19 hot spots in Massachusetts and how cases spread within and between communities, including the hardest-hit majority-minority communities, and we will determine the vulnerability factors that best explain these exposure and health outcome disparities.

项目概要我们中心的主要目标是了解和减少环境健康通过开展三个应用新颖的完全集成的研究项目来消除差异（EHD）流行病学、暴露科学和累积风险评估方法，具有很强的整个中心的社区参与。该中心强调多种健康成果整个生命过程中都有 EHD 的证据（出生结果、儿童增长率和心血管死亡率），在马萨诸塞州和两个低收入多数少数族群中社区（切尔西和多切斯特）。住房和邻里关系的影响整个过程都强调环境对多重暴露和健康结果的影响中心。在项目 3 中，我们使用新颖的地理空间数据和模拟技术来提供广泛且高度解析的一系列化学和非化学应激源暴露，包括项目 1 中生成的空间分辨空气污染和温度数据。在本补充文件中，我们将利用我们的项目 3 地理空间数据库，其中包含大量社会、住房、人口、和马萨诸塞州的环境暴露来评估种族/民族差异 COVID-19 病例、住院治疗和死亡。我们的地理空间漏洞数据将被链接具有地址级地理编码和每日时间分辨率的个人级 COVID-19 数据，由马萨诸塞州公共卫生部提供。我们将识别漏洞与各城市 COVID-19 感染发生率和严重程度差异相关的因素和马萨诸塞州的城镇，对每 10,000 人的病例发生率进行建模预测随着时间的推移，各城市/城镇每 10,000 人的住院人数。我们还将应用新颖的方法表征时空聚类，使我们能够确定时空差异 COVID-19 在城市/城镇内部和之间的传播模式，包括作为个人特征。最后，我们将研究城市/城镇特定政策的差异，国家政策的执行情况以及居民对公共卫生建议的看法，确定观察到的模式是否可以部分地用城市之间的差异来解释。有了这些通过分析，我们将确定马萨诸塞州的 COVID-19 热点以及病例如何在该地区传播以及社区之间，包括受灾最严重的多数少数社区，我们将确定最能解释这些暴露和健康结果的脆弱性因素差异。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Factors affecting lead dust in construction workers' homes in the Greater Boston Area.

影响大波士顿地区建筑工人住宅中铅尘的因素。

DOI：
发表时间：
2021-04
期刊：
影响因子：
8.3
作者：
Ceballos, Diana M;Herrick, Robert F;Dong, Zhao;Kalweit, Andrew;Miller, Melisa;Quinn, Jenna;Spengler, John D
通讯作者：
Spengler, John D

A Mixed Methods Evaluation of Sharing Air Pollution Results with Study Participants via Report-Back Communication.

通过反馈沟通与研究参与者分享空气污染结果的混合方法评估。

DOI：
发表时间：
2019-10-29
期刊：
影响因子：
0
作者：
Tomsho, Kathryn S;Schollaert, Claire;Aguilar, Temana;Bongiovanni, Roseann;Alvarez, Marty;Scammell, Madeleine K;Adamkiewicz, Gary
通讯作者：
Adamkiewicz, Gary

Characterizing the Environmental Health Literacy and Sensemaking of Indoor Air Quality of Research Participants.

表征研究参与者的环境健康素养和室内空气质量的意义。

DOI：
发表时间：
2022-02-16
期刊：
影响因子：
0
作者：
Tomsho, Kathryn S;Polka, Erin;Chacker, Stacey;Queeley, David;Alvarez, Marty;Scammell, Madeleine K;Emmons, Karen M;Rudd, Rima E;Adamkiewicz, Gary
通讯作者：
Adamkiewicz, Gary

One-Hour Pilot Training to Prevent Workers From Taking Home Workplace Contaminants.

一小时试点培训，防止工人将工作场所污染物带回家。