RENAL DISEASE EPIDEMIOLOGY--PREDICTORS OF OUTCOMES

肾病流行病学——结果预测因素

• 批准号: 2143022
• 负责人: GRETHE S TELL
• 金额: $ 26.69万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-20 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2143022
• 关键词: African American; caucasian American; chronic renal failure; data collection methodology /evaluation; disease /disorder proneness /risk; epidemiology; gender difference; human age group; human morbidity; human mortality; human subject; interview; longitudinal human study; medical records; prognosis; public health; quality of life; questionnaires; racial /ethnic difference; social psychology; social support network; socioeconomics; therapy compliance

End stage renal disease (ESRD) is a significant and growing public health problem. However, there is limited epidemiologic data available on predictors of outcome in treated ESRD, especially as it relates to minorities and to women. We propose to study, over a five year period, all patients served by the Piedmont Dialysis Center and its satellite units, the only dialysis facilities serving a large surrounding region. The patient population is approximately 50% black, 50% female, and is socioeconomically diverse. During the course of the study, 400 prevalent and 600 incident cases will be enrolled. The inclusion of both incident and prevalent cases affords study of the effects of risk factors in both the early and late stages of treated ESRD. The aims of the study are to : 1) describe the course and outcome of ESRD with a major emphasis on comparisons by race, gender, age and socioeconomic strata, and 2) study the effect of biomedical and psychosocial factors on ESRD outcome, including comparing different treatment modalities. The study endpoints are a) morbidity, b)mortality, and c)quality of life. An intermediate outcome is compliance with the medical regimen. All prevalent cases will be recruited and incident cases will be enrolled as they are referred for dialysis treatment. All cases will be examined every six months. Total person-years of follow-up will be at least 2,191 (follow-up will be a maximum of 3.5 years and a minimum of 1 year). Data collection will be by self- and interviewer administered questionnaires. Variables measured will include physical and mental health status, social support, and study endpoints as listed above. Medical charts and other records will be abstracted for data on medical compliance, morbidity, and causes of death. A total of 419 deaths are expected during the study period. The significance of the study rests with its potential to provide knowledge about modifiable factors that influence outcome in ESRD. Factors hypothesized to influence outcome include health status (comorbidity and disease severity), dialysis treatment modality, lipids and lipoproteins, social support and social network, dimensions of health quality of life, and compliance. The practical outcome of the study will be to apply its results to clinical trials designed to test interventions aimed at reducing the burden of ESRD.

末期肾脏疾病（ESRD）是一种重要且不断增长的公共卫生 问题。 但是，关于流行病学数据的有限 治疗ESRD中结果的预测因素，尤其是与 少数民族和妇女。 我们建议在五年内学习所有 皮埃蒙特透析中心及其卫星单位服务的患者， 唯一为周围地区提供大型地区的透析设施。 这 患者人数约为黑色50％，女性为50％，是 社会经济多样化。 在研究过程中，有400个流行 将注册600例事件案件。 包括两个事件 并且普遍的案件提供了对两者中风险因素的影响的研究 经过治疗的ESRD的早期和晚期。 该研究的目的是：1）描述ESRD的课程和结果 重点是种族，性别，年龄和社会经济的比较 地层和2）研究生物医学和社会心理因素对 ESRD结果，包括比较不同的治疗方式。 这 研究终点是a）发病率，b）死亡率和c）生活质量。 一个 中级结果是遵守医疗方案。 所有普遍的案件将被招募，事件案件将被招募 因为它们被转介进行透析治疗。 所有情况将检查 每六个月一次。 人数的总年度至少为2,191 （随访最多将为3。5年，至少为1年）。 数据 收集将由自我和访调员管理问卷。 测量的变量将包括身心健康状况，社会状况 支持和研究端点如上所述。 医疗图表和其他 记录将被摘要以获取有关医疗合规性，发病率和 死亡原因。 在研究期间，预计总共有419人死亡 时期。 研究的重要性在于其提供知识的潜力 关于影响ESRD结果的可修改因素。 因素 假设影响结果的结果包括健康状况（合并症和 疾病严重程度），透析治疗方式，脂质和脂蛋白， 社会支持和社交网络，健康质量的维度， 和合规性。 研究的实际结果将是应用其 临床试验的结果，旨在测试旨在减少的干预措施 ESRD的负担。