MICROSTRUCTURE OF INGESTIVE BEHAVIOR

摄取行为的微观结构

• 批准号: 2141815
• 负责人: JOHN M. DAVIS
• 金额: $ 9.01万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1996-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2141815
• 关键词: appetite; conditioning; denervation; dietary carbohydrates; dietary lipid; laboratory rat; nutrient intake activity; nutrition related tag; satiations; sham feeding; stomach emptying; taste

The overall objective of this proposal is to understand better how some of the variables such as taste and signals arising from the gastrointestinal tract interact during a meal to determine its size. The experimental approach used here measures the rate of occurrence of the rhythmic tongue movements that occur in rats when they are ingesting liquid diets. This approach allows the investigator to examine how the pattern of this licking behavior changes from the beginning of the meal to the end, and, thus to track the influence of variables that come into play at different times during the meal to modify its size. The use of this method has led to the discovery that meal size is controlled in part by a mechanism dependent upon an association between taste of the test diet and its post gastric consequences. This inhibition is revealed as a progressive increase in the rate of ingestion early in a meal when rats are given experience ingesting a liquid diet that does not stimulate the post gastric compartment. The end result is a significant increase in the size of the meals. The aims of this proposal are to study this phenomenon in detail to attempt to determine the nature of the post gastric signal(s) and the pathway or pathways by which this information is conveyed to the central nervous system. This will be achieved by manipulating post gastric stimulation independent of that the animal is eating and by severing some of the afferent pathways from the gastrointestinal tract to the brain. An understanding of the types of signals that participate in the normal control of the amount of food that is ingested in a meal and their mode of action in normal animals is essential to a better understanding of the pathologies such as anorexia and bulemia that can occur and to a better understanding of the problem of obesity.

该提议的总体目的是更好地了解一些 在诸如味道和信号之类的变量中产生的变量 胃肠道在饭期间相互作用以确定其大小。 这 这里使用的实验方法测量了 摄取大鼠时发生的节奏舌头运动 液体饮食。 这种方法使研究人员可以检查 这种舔行为的模式从饭开始就改变了 到最后，因此跟踪变量的影响 在用餐期间在不同时间玩耍以修改其尺寸。 使用 这种方法导致发现进餐的大小是部分控制的 通过依赖于测试口味的关联的机制 饮食及其胃后后果。这种抑制作用被揭示为 大鼠早期摄入的摄入率逐渐增加 有经验摄取不会刺激的液体饮食的经验 胃室后。 最终结果是显着增加 饭菜的大小。 该提议的目的是研究此事 详细的现象试图确定帖子的性质 胃信号和此信息的途径或途径 被传达给中枢神经系统。这将通过 操纵胃后刺激与动物无关 进食，通过切断一些传入途径 胃肠道向大脑。对类型的理解 参与正常控制食物量的信号 摄入一餐，它们在普通动物中的作用方式是 更好地理解诸如厌食症之类的病理学至关重要 和可能发生的泡沫症，并更好地理解问题 肥胖。