Nighttime Agitation and Restless Legs Syndrome in People with Alzheimer's Disease

阿尔茨海默病患者的夜间躁动和不宁腿综合症

基本信息

批准号：
10167515
负责人：
Kathy Culpepper Richards
金额：
$ 53.15万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10167515
关键词：
Academy Administrative Supplement Adverse event Aggressive behavior Agitation Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Americas Antipsychotic Agents Behavior COVID-19 Caregiver Burden Caregiver support Caregivers Cessation of life Clinical Trials Cognition Cognitive Control Groups Data Data Collection Dementia Development Diagnosis Diagnostic Procedure Disinhibition Distress Double-Blind Method Effectiveness Elderly Esthesia Etiology FDA approved Facebook Family Family Caregiver Frequencies Funding Future Health Care Costs Home Nursing Care Hour Independent Living Intervention Interview Knowledge Leg Loudness Mediating Medicine Methods Movement Nature Nursing Homes Observational Study Participant Patients Personal Satisfaction Persons Pharmaceutical Preparations Pharmacological Treatment Pharmacology Physical Function Physical activity Placebo Control Placebos Policies Polysomnography Population Positioning Attribute Press Releases Provider Reporting Research Research Design Rest Restless Legs Syndrome Safety Services Sleep Sleep Disorders Social Distance Stroke Sunlight Surveys Symptoms Translating United States Food and Drug Administration Work arm clinical practice community setting cost dosage emotional distress exhaustion fall risk falls follow-up gabapentin improved interest neuropsychiatric symptom patient population primary endpoint randomized placebo-controlled clinical trial response safety assessment safety outcomes sleep pattern social social media tool treatment group treatment research virtual vocalization

项目摘要

Summary/Abstract. Factors associated with Covid-19 social distancing – such as isolation from family, restricted movement, insufficient sunlight and social and physical activity, lack of caregiver support services, and caregiver exhaustion - may adversely impact the well-being of older adults with Alzheimer’s disease related dementia. Because older adults with dementia are cognitively and verbally unable to express their distress, and both sunlight and activity are necessary for healthy sleep patterns, social distancing may increase agitation behaviors, worsen sleep patterns, and increase prescriptions for antipsychotics and sedating medications to manage these problems. We propose an Administrative Supplement to the NightRest study, R01AG051588, to determine the impact of social distancing on the well-being of older adults with Alzheimer’s disease related dementia. The primary specific aim is to determine the impact of social distancing on nighttime agitation and sleep. The hypothesis is: social distancing will result in more nighttime agitation and less sleep. Aim 2 will explore the impact of social distancing on physical function and use of antipsychotics and other sedating medications. Aim 3 will explore the impact of social distancing from the perspectives of family caregivers using qualitative interviews and a Facebook survey. The research will employ an observational study design. Participants from the NightRest trial, 50 pre- and 50 post-Covid-19, living independently or in nursing homes, matched on relevant variables, will be used for Aims 1 and 2. Content analysis of 30 family caregiver qualitative interviews (Aim 3) will result in a list of priorities to minimize the impact of social distancing. Family caregivers accessed via a Facebook survey will rank and add to the priorities. Because the NightRest study team possesses pre-Covid-19 data, has access to family caregivers who have expressed interest in future studies, and has developed and piloted virtual data collection methods, we are uniquely positioned to determine the impact of Covid-19 social distancing policies on well-being. We also have the ability and the networks to translate the findings. The results will be widely disseminated in November/December, 2020 to stakeholders and other policy influencers through social media, press releases, and presentations. The proposed project may result in more tailored social distancing policies in the future. Further, dissemination of nursing home realities to a world closely following Covid-19 developments may ultimately result in better nursing home care, not just for now, but also in the future.

摘要/摘要。与 Covid-19 社交距离相关的因素——例如与家人隔离、限制运动、阳光不足、社交和体力活动不足、缺乏护理人员支持服务和护理人员疲惫不堪 - 可能会对老年人的福祉产生不利影响阿尔茨海默病与痴呆症有关，因为患有痴呆症的老年人是这样的。无法用语言表达他们的痛苦，阳光和活动都是健康所必需的睡眠模式、社交距离可能会增加烦躁行为、恶化睡眠模式，增加抗精神病药物和镇静药物的处方来解决这些问题。我们提出了 NightRest 研究的行政补充，R01AG051588，以确定社交距离对患有阿尔茨海默病的老年人的福祉的影响疾病相关的痴呆症的主要具体目标是确定社会的影响。保持社交距离会影响夜间躁动和睡眠。假设是：保持社交距离会导致社交距离增加。夜间烦躁和睡眠减少将探讨社交距离对的影响。目标 3 将探讨身体功能以及抗精神病药物和其他镇静药物的使用。使用定性方法从家庭照顾者的角度来看社会距离的影响该研究将采用观察性研究设计。 NightRest 试验的参与者中，有 50 名 Covid-19 感染前和 50 名感染后，独立生活或居住在匹配相关变量的疗养院将用于目标 1 和 2。内容分析 30 名看护者家庭定性访谈（目标 3）将产生一份优先事项清单，以尽量减少通过 Facebook 调查访问的家庭护理人员将进行排名和影响。添加到优先事项中。因为 NightRest 研究团队拥有 Covid-19 之前的数据，可以接触到家人表示对未来研究感兴趣并已开发和试点虚拟的护理人员通过数据收集方法，我们具有独特的优势来确定 Covid-19 社会影响我们也有能力和网络来转化这些政策。结果将于 2020 年 11 月/12 月向利益相关者广泛传播。通过社交媒体、新闻稿和演示等方式与其他政策影响者进行交流。此外，拟议的项目可能会在未来产生更有针对性的社会疏远政策。向世界传播疗养院的现实情况，密切关注 Covid-19 的发展可能会最终带来更好的疗养院护理，不仅是现在，而且是未来。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comorbid Nighttime Agitation, Sleep Disturbance, and Restless Legs Syndrome: What Next?

共存的夜间躁动、睡眠障碍和不宁腿综合症：接下来怎么办？

DOI：
发表时间：
2017-07-01
期刊：
影响因子：
0
作者：
Richards, Kathy C;Kovach, Christine R
通讯作者：
Kovach, Christine R

"Please Don't Forget Us": A Descriptive Qualitative Study of Caregivers of Older Adults With Alzheimer's Disease and Related Dementias During the COVID-19 Pandemic.

“请不要忘记我们”：对 COVID-19 大流行期间患有阿尔茨海默病和相关痴呆症的老年人的护理人员进行的描述性定性研究。

DOI：
发表时间：
2022
期刊：
影响因子：
0
作者：
Richards, Kathy C;Radhakrishnan, Kavita;Britt, Katherine Carroll;Vanags;Park, Eunice;Gooneratne, Nalaka S;Fry, Liam
通讯作者：
Fry, Liam

Religion, Spirituality, and Coping During the Pandemic: Perspectives of Dementia Caregivers.

大流行期间的宗教、灵性和应对：痴呆症护理人员的观点。

DOI：
发表时间：
2023-01
期刊：
影响因子：
1.7
作者：
Britt, Katherine Carroll;Richards, Kathy C;Radhakrishnan, Kavita;Vanags;Park, Eunice;Gooneratne, Nalaka S;Fry, Liam
通讯作者：
Fry, Liam

Sleep and Memory: The Promise of Precision Medicine.

睡眠和记忆：精准医学的前景。