Characterizing the effects of family history of alcoholism on alcohol analgesia

描述酒精中毒家族史对酒精镇痛的影响

• 批准号: 10165418
• 负责人: Jeffrey B Boissoneault
• 金额: $ 51.02万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-05 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10165418
• 关键词: Absence of pain sensation; Acute; Acute Pain; Address; Affect; Affective; Alcohol consumption; Alcoholism; Alcohols; American; Amygdaloid structure; Analgesics; Anterior; Behavior; Biological; Brain; Chronic; Clinical; Cognitive; Data; Expectancy; Family; Family history of; Feeling; Goals; Health; Hypothalamic structure; Image; Individual; Insula of Reil; Intake; Intuition; Knowledge; Medial; Modeling; Moods; Motivation; Musculoskeletal Pain; Negative Reinforcer; Neurobiology; Neurotransmitters; Nucleus Accumbens; Opioid; Opioid Analgesics; Opioid agonist; Oral; Pain; Pain management; Pain-Free; Patients; Personality; Pharmacology; Placebo Effect; Prefrontal Cortex; Quality of life; Recording of previous events; Reporting; Research; Risk; Risk Behaviors; Role; Self Administration; Self Medication; Self-Injurious Behavior; Sex Differences; Somatosensory Cortex; Stimulus; Structure; Subgroup; System; Testing; Thalamic structure; Tissues; Woman; Work; addiction; alcohol effect; alcohol response; alcohol sensitivity; alcohol use disorder; base; biopsychosocial; chronic pain; chronic pain patient; cingulate cortex; conditioning; cost; drinking; efficacious treatment; expectation; experience; improved; interest; medical attention; men; neural correlate; neuromechanism; oral pain; pain chronification; pain processing; pain reduction; pain relief; pain sensitivity; psychologic; response; sex

Project Summary Pain is the most common reason that patients seek medical attention. Acute pain is an essential indicator of current or impending tissue damage. However, chronic pain is a maladaptive state with strong affective, biological, and psychological components. Chronic pain is extremely costly and has strong negative effects on sufferers’ quality of life. Existing treatments for chronic pain, including opioid analgesics, are relatively ineffective. Perhaps as a result of the lack of efficacious treatments, it has been recently reported that nearly 25% of individuals suffering from chronic oral and/or musculoskeletal pain self-medicate through the oral consumption of alcohol. Indeed, alcohol interacts with a wide range of relevant pharmacologic targets capable of modulating the experience of pain. However, the biological mechanisms underlying this intuitive interaction are not well established. This relationship is important to understand because alcohol analgesia may act as a potent negative reinforcer for alcohol intake, which, in turn, can have adverse health effects by increasing risk of developing an alcohol use disorder. Familial risk for alcoholism, along with sex and certain mood/personality factors, may act as critical modulators of individual sensitivity to alcohol analgesia. However, it is currently unclear whether this sensitivity is the result of neurobiological, and/or learned factors. By characterizing independent contributions of each of these factors, this proposal will improve understanding of the interplay between pain/alcohol sensitivity, sex, and family history of alcoholism as a modulator of sensitivity to alcohol analgesia. These efforts will inform further research and clinical/translational efforts regarding risk associated with self-medication of pain by consuming alcohol. Critically, the impact of these factors on the functional neural correlates of alcohol analgesia will also be determined, improving mechanistic understanding of alcohol analgesia.

项目概要 疼痛是患者就医的最常见原因。急性疼痛是重要的指标。 然而，慢性疼痛是一种具有强烈情感的适应不良状态。 慢性疼痛的成本极高，并且对人有强烈的负面影响。 现有的慢性疼痛治疗方法，包括阿片类镇痛药，患者的生活质量相对较低。 也许是由于缺乏有效的治疗方法，最近有报道称几乎没有效果。 25% 患有慢性口腔和/或肌肉骨骼疼痛的人通过口腔进行自我治疗 事实上，酒精与多种相关的药理靶标相互作用。 然而，这种直觉相互作用背后的生物机制。 理解这种关系很重要，因为酒精镇痛可能会起到镇痛作用。 酒精摄入的强效负面强化物，反过来又会增加风险，从而对健康产生不利影响 患有酒精中毒的家族风险，以及性和某些情绪/性格。 因素，可能是个体对酒精镇痛敏感性的关键调节剂，但目前它是。 不清楚这种敏感性是否是神经生物学和/或习得因素的结果。 每个因素的独立贡献，该提案将增进对相互作用的理解 疼痛/酒精敏感性、性别和酗酒家族史之间作为酒精敏感性调节因素 这些努力将为有关风险相关的进一步研究和临床/转化工作提供信息。 重要的是，这些因素对功能的影响。 还将确定酒精镇痛的神经相关性，提高对酒精机制的理解 镇痛。