Core A: Administrative

核心A：行政

• 批准号: 10165492
• 负责人: James L Riley
• 金额: $ 8.09万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10165492
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Administrator; Advisory Committees; Annual Reports; Award; BLT mice; Basic Science; Biometry; Budgets; CAR T cell therapy; Clinical; Clinical Trials; Communication; Congresses; Ensure; Genome; Goals; Government Agencies; Guidelines; HIV; HIV-1; Home; Human Resources; Immunology; Individual; Laboratories; Logistics; Mission; Modeling; Modification; Monitor; National Institute of Allergy and Infectious Disease; Occupational activity of managing finances; Outcome; Pharmacologic Substance; Phase I Clinical Trials; Preparation; Principal Investigator; Private Sector; Productivity; Progress Reports; Publications; Reporting; Research; Research Personnel; Resource Allocation; Scientist; Structure; T cell response; T-Lymphocyte; Testing; Therapeutic; Time; TimeLine; United States National Institutes of Health; Viral reservoir; Work; antiretroviral therapy; bench to bedside; clinical center; clinical epidemiology; clinical trial implementation; data management; data sharing; design; engineered T cells; experience; genome analysis; innovation; manufacturing process; meetings; novel strategies; preclinical evaluation; programs; targeted nucleases; tool; trafficking; working group

CORE A: ABSTRACT Core A will be responsible for providing administrative and biostatistics support for the overall program project. The Core will interact with Program management at NIAID and with the external Scientific Advisory Panel, coordinating meetings and progress reports. Budget reports and annual reports to NIH and FDA will be coordinated by Core A. It will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of pre- clinical and clinical efforts to focus efforts on enhancing the clinical outcome. The administrative functions will be accomplished using a structure in which the Core Leader, Dr. Riley, is advised by an Executive Committee of Project and Core Leaders with input from the Scientific Advisory Committee. The finances and meeting logistics of the U19 will be organized by Ms. Chelsey Molineaux who will meet monthly with the U19 PI and each Project and Core Leader. Dr. Shaw will provide comprehensive biostatistics support for the scientific project and core, and for the design and implementation of the clinical trial. Therefore, the specific aims are: SA1: To coordinate the interactions among scientists, private sector partners, and NIH personnel regarding efficient implementation of proposed plans and projects. SA2: To oversee all budgetary matters, including monitoring of monthly expenses and preparation of non-competitive renewal applications. SA3: To provide statistical support for projects, especially the proposed clinical trial in Project 4

核心 A：摘要 核心 A 将负责为整体提供行政和生物统计支持 计划项目。核心将与 NIAID 的项目管理部门以及 外部科学顾问小组，协调会议和进度报告。预算报告 向 NIH 和 FDA 提交的年度报告将由核心 A 进行协调。它也将有助于 将研究人员、他们的实验结果和他们的想法结合起来，对预评估进行评估 临床和临床工作的重点是提高临床结果。行政方面 职能将使用核心领导者 Riley 博士建议的结构来完成 由项目执行委员会和核心领导者根据科学顾问的意见制定 委员会。 U19 的财务和会议后勤工作将由 Chelsey 女士负责组织 Molineaux 将每月与 U19 PI 以及每个项目和核心负责人会面。肖博士 将为科学项目和核心提供全面的生物统计学支持 临床试验的设计和实施。因此，具体目标是： SA1：协调科学家、私营部门合作伙伴和 NIH 之间的互动 有效实施拟议计划和项目的人员。 SA2：监督所有预算事项，包括监控每月支出和 准备非竞争性续展申请。 SA3：为项目，特别是项目4中拟议的临床试验提供统计支持