Postdoctoral training in genomic medicine research

基因组医学研究博士后培训

基本信息

批准号：
10163232
负责人：
KATHLEEN A COONEY
金额：
$ 49.42万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-14 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10163232
关键词：
Genomic medicine Research post-doctoral training

项目摘要

The overarching goal of this NRSA application is to provide a high quality mentored training experience for promising clinical and translational researchers in the rapidly growing area of genomic and precision medicine to gain the knowledge and skills to enable them to successfully establish independent clinical research programs. Future genomic medicine investigators will require a strong foundation of specialized training to continue making new discoveries and to develop the translational research programs that enable implementation of new genomic discoveries into clinical care. We propose a 2-year postdoctoral training program, offering trainees a range of research opportunities in applied clinical and translational genomic medicine research (wet or dry lab), bioinformatics and computational biology, engineering, and statistics to eligible applicants with an MD or PhD. We are requesting 2 training slots in Year 1, and 4 slots thereafter. At least three existing or proposed T32 programs at Duke will donate a slot to this T32 leveraging the NIH investment in this program. Duke’s commitment to interdisciplinary research in genomic medicine will attract promising and diverse post-doctoral fellows across the life sciences. We have assembled 27 senior investigators as mentors and 24 junior investigators as co-mentors for this program. The mentored research experience will require trainees to establish, with the assistance of the program directors (PDs), an interdisciplinary mentoring team consisting of 2 or 3 mentors to guide their research program and career development. The research training experience will be designed to provide specialized training and will also consider broader issues impacted by their research including ethical, legal, and social implications. Supporting their research will be laboratory rotations for select research techniques, a suite of coursework and informal learning opportunities. A minimal core set of courses in genomics, clinical research, statistics and ethics must be completed by each trainee; additional elective courses may be taken to support the trainee’s research focus. Trainees will be required to meet with the PDs quarterly. Regular meetings of the trainee and his/her mentorship team will provide ongoing assessment of progress that will be reported and evaluated by the PDs and the program’s Executive Committee. Trainees will be required to present their research at Duke conferences and at national meetings and submit manuscripts for peer-reviewed publications. The mentorship team and the Executive Committee will assist each trainee to apply for grant opportunities and obtain a post- fellowship faculty position in academia or relevant sector that will allow continuation of his/her research. Trainees must spend at least 75% effort while they are supported; the trainees’ clinical experience will be highly focused on the practice of genomic medicine in genomic medicine practice environments at Duke. Trainees in this program will benefit from the rich and highly interdisciplinary resources available at Duke for clinical and translational genomic medicine research and build upon its strong history and experience in post- doctoral training.

此 NRSA 应用程序的总体目标是为以下人员提供高质量的指导培训体验：在快速发展的基因组和精准医学领域有前途的临床和转化研究人员获得知识和技能，使他们能够成功建立独立的临床研究未来的基因组医学研究人员将需要坚实的专业培训基础继续做出新的发现并开发转化研究项目，使我们建议将新的基因组发现应用于临床护理。计划，为学员提供一系列应用临床和转化基因组研究机会医学研究（湿或干实验室）、生物信息学和计算生物学、工程学和统计学符合医学博士或博士学位资格的申请者我们要求第一年有 2 个培训名额，此后有 4 个培训名额。杜克大学至少三个现有或拟议的 T32 项目将利用 NIH 为该 T32 捐赠一个位置杜克大学对基因组医学跨学科研究的投资将吸引人们的关注。我们聚集了 27 名生命科学领域有前途且多元化的博士后研究员。研究者作为导师，24 名初级研究者作为该项目的共同导师。经验将要求受训者在项目主管（PD）的帮助下建立一个由 2 至 3 名导师组成的跨学科指导团队，指导他们的研究计划和职业生涯研究培训经验将旨在提供专门培训，并且还将提供。考虑受其研究影响的更广泛问题，包括伦理、法律和社会影响。他们的研究将是实验室轮换，以选择研究技术、一套课程作业和非正式的必须有一套最基本的基因组学、临床研究、统计学和伦理学核心课程。由每个受训者完成；可以采取额外的选修课程来支持受训者的研究受训者必须每季度与受训者及其他/她定期举行会议。指导团队将持续评估进展情况，并由项目负责人报告和评估该项目的执行委员会将要求学员在杜克大学展示他们的研究成果。会议和国家会议，并提交同行评审出版物的手稿。团队和执行委员会将协助每位学员申请资助机会并获得后期培训学术界或相关部门的研究员职位，这将允许他/她继续研究。受训者必须付出至少75%的努力，而受训者的临床经验将得到支持；高度关注杜克大学基因组医学实践环境中的基因组医学实践。该项目的学员将受益于杜克大学丰富且高度跨学科的资源临床和转化基因组医学研究，并以其丰富的历史和经验为基础博士培训。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

An Update on the Treatment of Pediatric Autoimmune Encephalitis.

儿童自身免疫性脑炎治疗的最新进展。

DOI：
发表时间：
2018-03
期刊：
影响因子：
0
作者：
Stingl, Cory;Cardinale, Kathleen;Van Mater, Heather
通讯作者：
Van Mater, Heather

Germline Variants in DNA Damage Repair Genes and HOXB13 Among Black Patients With Early-Onset Prostate Cancer.

早发性前列腺癌黑人患者中 DNA 损伤修复基因和 HOXB13 的种系变异。

DOI：
发表时间：
2022-11
期刊：
影响因子：
4.6
作者：
Trendowski, Matthew R;Sample, Christopher;Baird, Tara;Sadeghpour, Azita;Moon, David;Ruterbusch, Julie J;Beebe;Cooney, Kathleen A
通讯作者：
Cooney, Kathleen A

Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells.

非霍奇金淋巴瘤：由成熟 B 细胞引起的恶性肿瘤。

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Shingleton, Jennifer;Wang, Jie;Baloh, Carolyn;Dave, Tushar;Davis, Nicholas;Happ, Lanie;Jadi, Othmane;Kositsky, Rachel;Li, Xiang;Love, Cassandra;Panea, Razvan;Qin, Qiu;Reddy, Anupama;Singhi, Naina;Smith, Eileen;Thakkar, Devang;Dave, Sandeep
通讯作者：
Dave, Sandeep

Amount and intensity effects of exercise training alone versus a combined diet and exercise lifestyle intervention on health-related quality of life in the STRRIDE-PD randomized trial.

STRRIDE-PD 随机试验中，单独运动训练与饮食和运动生活方式相结合的干预措施对健康相关生活质量的影响。

DOI：
发表时间：
2022-01
期刊：
影响因子：
4.1
作者：
Collins, Katherine A;Ross, Leanna M;Piner, Lucy W;Fos, Liezl B;Slentz, Cris A;Bateman, Lori A;Willis, Leslie H;Bales, Connie W;Siegler, Ilene C;Wolever, Ruth Q;Huffman, Kim M;Kraus, William E
通讯作者：
Kraus, William E

Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation.

对 CRISPR-Cas9 编辑的斑马鱼外显子组中单核苷酸变体的分析显示没有脱靶膨胀的证据。