Tissue Engineering Resource Center-Treatment of COVID-19 induced acute respiratory distress by inhalation of exosomes

组织工程资源中心-吸入外泌体治疗COVID-19引起的急性呼吸窘迫

• 批准号: 10164179
• 负责人: Gordana Vunjak-Novakovic
• 金额: $ 46.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-27 至 2021-07-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10164179
• 关键词: Academic Medical Centers; Adult Respiratory Distress Syndrome; Advisory Committees; Area; Automation; Awareness; Basic Science; Biocompatible Materials; Biological; Biomedical Engineering; Bioreactors; COVID-19; Cells; Clinic; Clinical; Collaborations; Communities; Complex; Development; Disease; Disease model; Education and Outreach; Engineering; Ensure; Environment; Event; Feedback; Financial Support; Fostering; Foundations; General Population; Goals; Heart; High School Student; Hospitals; Human; Human Engineering; Image; In Vitro; Inhalation; Institution; Lead; Leadership; Letters; Link; Measurement; Measures; Mission; Modality; Myocardial Infarction; Natural regeneration; Optics; Organ; Outcome; Perfusion; Physiological Processes; Presbyterian Church; Recording of previous events; Regenerative Medicine; Research; Research Ethics; Research Personnel; Resources; Role; Schools; Services; Signal Transduction; Strategic Planning; Structure; Students; System; Technology; Therapeutic; Time; Tissue Engineering; Tissues; Training; Translating; Translational Research; Translations; Universities; Vision; Visualization; base; cellular imaging; clinical practice; clinical translation; design; driving force; exosome; experience; functional restoration; human tissue; improved; in vivo; innovation; lung regeneration; new technology; next generation; operation; outreach; outreach program; program dissemination; public health relevance; regenerative; response; restoration; scaffold; screening; spatiotemporal; technology development; technology research and development; tissue culture; treatment center

SUMMARY Tissue engineering is rapidly developing, but remains limited by (i) scaffold and bioreactor designs that are based on predetermined parameters, and (ii) the lack of real-time, nondestructive measurements of cell and tissue function. To overcome these two limitations, we will develop adaptive-responsive biomaterials that can sense environmental signals and actuate the cells, and imaging-enabled bioreactors with real-time spatiotemporal control of engineered tissues with feedback from the measured cell responses. Our goal is to offer these advances to the tissue engineering community, and translate them into clinic. The proposed Tissue Engineering Resource Center brings together four highly productive and actively collaborating investigators from Columbia University (lead institution), Tufts University and Columbia University Medical Center-Presbyterian Hospital. An Administrative Board will coordinate the Center's activities, in conjunction with an External Advisory Committee, formed from the world leaders in tissue engineering and clinical translation that will evaluate the Center and provide guidance in strategic planning. The Center will partner with a number of existing resources (please see 13 letters of collaboration), and will have very generous financial support of the Columbia University School of Engineering ($2,425,000 over the five-year cycle). Strong and effective leadership is uniquely suited to support this transformative Center. The technical components of the Center are three Technology Research and Development Projects (TRD1: Adaptive-responsive biomaterials; TRD2: Imaging enabled bioreactor systems; TRD3: Regenerative engineering), eight Collaborative Projects and six Service Projects. We also propose a robust and diverse Training and Dissemination program to provide links between the projects in the Center with training of biomedical investigators in the use of new technologies, and the outreach to students, general public and underserved communities. Our mission is is that the Center will serve as a transformative driving force for the field of tissue engineering, by developing and translating new technologies, providing training and service, and offering dissemination and outreach programs for general public and high school students. With a highly innovative scientific premise, extensive foundational research, strong leadership and institutional support, experience in translational research, and long history of collaboration among the lead investigators, we are confident that the Center will accomplish its mission.

概括 组织工程正在迅速发展，但仍然受到以下因素的限制：(i) 支架和生物反应器设计 基于预定参数，以及（ii）缺乏对细胞的实时、无损测量 和组织功能。为了克服这两个限制，我们将开发适应性响应生物材料 可以感知环境信号并激活细胞，以及具有实时成像功能的生物反应器 通过测量的细胞反应的反馈对工程组织进行时空控制。我们的目标是 向组织工程界提供这些进步，并将其转化为临床。拟议的 组织工程资源中心汇集了四个高效且积极合作的组织工程资源中心 来自哥伦比亚大学（牵头机构）、塔夫茨大学和哥伦比亚大学医学院的研究人员 中心长老会医院。行政委员会将协调中心的活动，并与 设有外部咨询委员会，由组织工程和临床领域的世界领导者组成 翻译将评估该中心并为战略规划提供指导。中心将合作 拥有一些现有资源（请参阅13封合作信），并将有非常慷慨的 哥伦比亚大学工程学院的财政支持（五年周期 2,425,000 美元）。 强大而有效的领导力非常适合支持这个变革性的中心。 中心技术组成为三个技术研发项目 （TRD1：自适应响应生物材料；TRD2：成像生物反应器系统；TRD3： 再生工程）、八个合作项目和六个服务项目。我们还提出了一个 强大而多样化的培训和传播计划，以提供项目之间的联系 该中心对生物医学研究人员进行新技术使用方面的培训，并推广 学生、公众和服务不足的社区。我们的使命是该中心将作为 通过开发和转化新的组织工程领域的变革驱动力 技术，提供培训和服务，并为一般人提供传播和外展计划 公立和高中学生。具有高度创新的科学前提、广泛的基础 研究、强有力的领导和机构支持、转化研究经验以及悠久的历史 通过主要研究人员之间的合作，我们相信该中心将完成其使命。