CILIARY MECHANICS IN THE ADULT ORGAN OF CORTI

成人柯蒂氏器官的纤毛力学

• 批准号: 3424735
• 负责人: RICHARD John HALLWORTH
• 金额: $ 2.54万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3424735
• 关键词: biomechanics; cilium; cochlea; ear hair cell; laboratory mouse; organ of Corti; psychoacoustics; voltage /patch clamp

The long-term objective of this study is to examine force generation by hair cell cilia in the adult organ of Corti. Knowledge of cilia physiology is central to our understanding of cochlear transduction. Further, force generation by cilia is a likely source of mechanical energy input to the cochlea, and may therefore contribute to cochlear frequency selectivity and the generation of acoustic emissions. Specifically, the studies are designed to help develop a preparation to enable in vitro studies of cochlear hair cell cilia.

这项研究的长期目的是检查力的产生 毛细胞纤毛在成年的Corti器官中。 了解纤毛 生理学对于我们对人工耳蜗转导的理解至关重要。 此外，纤毛产生力是机械的可能来源 对耳蜗的能量输入，因此可能有助于人工耳蜗 频率选择性和声学排放的产生。 具体而言，研究旨在帮助制定准备工作 实现对耳蜗纤毛的体外研究。