STATISTICAL SOFTWARE FOR FRAILITY MODELS IN EPIDEMIOLOGY

流行病学脆弱模型统计软件

• 批准号: 2101847
• 负责人: David Oakes
• 金额: $ 4.59万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2101847
• 关键词: cancer information system; computer program /software; computer simulation; human data; human mortality; mathematical model; monograph; neoplasm /cancer epidemiology; statistics /biometry

The general objective of this work will be to develop tested and documented software and corresponding expository material to facilitate the application of new techniques for the analysis of survival data with random effects ("frailties") to clinical and epidemiologic studies of cancer. Specific products to be developed include: (a)A package for generating simulated data from random effects models, including models with gamma,inverse Gaussian, k-point, and stable frailty distributions. (b) Programs (written in C and in some cases interfacing with "S-plus' "BMDP" or "mathematica") for fitting random effects models to survival data in parametric and semiparametric models and providing appropriate diagnostics to assess goodness-of-fit. (c) Tables and nomograms for assessing the influence of unobserved random effects (including that due to "errors in variables") on power calculations for epidemiologic studies. (d) Expository material in the form of a monograph or lecture notes explaining the use of the techniques, oriented toward a clinical and epidemiologic audience. The products will be tested on data from a large cohort study of lung cancer mortality among asbestos workers, and other sets of survival data in the cancer literature.

这项工作的一般目标将是开发经过测试和 记录的软件和相应的说明性材料以促进 新技术在分析生存数据中的应用 随机影响（“脆弱”）对临床和流行病学研究 癌症。 要开发的特定产品包括： （a）用于从随机效应模型中生成模拟数据的软件包， 包括具有伽玛，逆高斯，K点和稳定脆弱的型号 分布。 （b）程序（用C编写，在某些情况下与“ S-Plus”接口 “ BMDP”或“ Mathematica”）用于拟合随机效应模型的生存 参数模型和半参数模型的数据并提供适当的数据 评估拟合优度的诊断。 （c）评估未观察到的随机影响的表和列表 效果（包括“变量错误”引起的效果） 流行病学研究的计算。 （d）专着或讲义的形式的说明性材料 解释技术的使用，以临床为导向 流行病学受众。 这些产品将对来自肺的大型队列研究进行测试 石棉工人和其他生存数据的癌症死亡率 在癌症文献中。