The molecular basis of T cell receptor cross-reactivity between MHC and MR1

MHC 和 MR1 之间 T 细胞受体交叉反应的分子基础

• 批准号: DP240102905
• 负责人: Prof James McCluskey
• 金额: $ 41.9万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102905
• 关键词: molecular; basis; cell; receptor; cross

This project aims to investigate how newly discovered immune cells, known as 'MR1T' cells, function in the body. Preliminary evidence shows that MR1T cells can kill stressed cells. This project expects to generate new knowledge describing precisely how MR1T cells target and kill stressed cells. Expected outcomes of this project include to refine research techniques and models, foster interinstitutional collaborations, and further develop our theory on MR1T cell function. This project should provide significant benefits, such as publication of research articles in high impact journals and generation of experimental tools sought after by researchers in the field.

该项目旨在调查新发现的免疫细胞（称为“ MR1T”细胞）在体内起作用。初步证据表明，MR1T细胞可以杀死压力细胞。该项目预计将产生新的知识，以准确描述MR1T细胞靶向和杀死压力细胞。该项目的预期结果包括完善研究技术和模型，促进机构间合作，并进一步发展我们关于MR1T细胞功能的理论。该项目应提供巨大的好处，例如在高影响期刊上发表研究文章以及该领域研究人员追求的实验工具的生成。