CORE--NEUROPATHOLOGY

核心--神经病理学

• 批准号: 3746407
• 负责人: CHARLES L WHITE
• 金额: --
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3746407
• 关键词: Alzheimer's disease; biomedical facility; biopsy; hippocampus; human tissue; immunocytochemistry; medical records; mental disorder diagnosis; neocortex; nervous system disorder diagnosis; neuritic plaques; neurofibrillary tangles; postmortem; tissue resource /registry

Alzheimer disease (AD) remains a clinico-pathologic entity. A definitive diagnosis of AD requires the microscopic identification and neurofibrillary tangles (NFT) and senile plaques (SP) in appropriate density in hippocampus and neocortex in a patient who was clinically demented. In addition, no completely suitable animal model of AD exists yet, so researchers must utilize human tissue to characterize the alterations in the brain associated with AD. The major responsibilities of the Neuropathology Core will be to perform the neuropathological studies necessary to document the diagnosis of AD or other pathological entities in all human brain specimens used in research studies, and to provide clinico-pathologic correlation for ADC Clinical Core patients. Therefore, we will maintain a human brain bank wherein we propose 1) to collect, prepare, evaluate, catalog, store, and distribute well- characterized postmortem brain tissue and other samples from decreased demented and control patients for use in research; 2) to report qualitative and quantitative diagnostic information to physicians, families, and researchers; 3) to work with the Clinical Core to acquire relevant medical records regarding patients' illnesses, including detailed perimortem information (circumstances surrounding death); and 4) to regularly update the central ADC database with diagnostic and other related information on autopsied and biopsied patients.

阿尔茨海默氏病（AD）仍然是临床病理学实体。确定的 AD的诊断需要微观识别和 适当的神经原纤维缠结（NFT）和老年斑块（SP） 临床上的患者海马和新皮层的密度 痴呆。另外，不存在完全合适的AD动物模型 但是，研究人员必须利用人体组织来表征 与AD相关的大脑的改变。主要责任 神经病理学的核心将是执行神经病理学 记录AD或其他病理诊断所需的研究 研究研究中使用的所有人类脑标本的实体， 为ADC临床核心患者提供临床病理相关性。 因此，我们将维护一个人脑库，其中我们建议1） 收集，准备，评估，分类，存储和分发良好 表征了死后脑组织和其他样品 痴呆和控制患者用于研究； 2）报告 定性和定量诊断信息给医生， 家庭和研究人员； 3）与临床核心合作以获取 有关患者病的相关病历，包括 详细的外围信息（围绕死亡的情况）；和 4）定期使用诊断和其他的中央ADC数据库更新 有关尸检和活检患者的相关信息。