STATISTICAL ANALYSIS OF BIOMARKERS OF AGING

衰老生物标志物的统计分析

• 批准号: 2052286
• 负责人: TARYNN Madysyn WITTEN
• 金额: $ 4.34万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-10 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2052286
• 关键词: aging; biomarker; computer simulation; data collection methodology /evaluation; genetic models; genotype; mathematical model; statistics /biometry

The complex phenomenon of aging has been observed in nearly all multicellular organisms that have been studied. The purpose of this proposal is to produce a single panel of biomarkers of aging, based upon rodent animal models. In particular, this proposal responds to the request for a comprehensive statistical analysis designed to bring together the results of all of the research conducted as a part of this Biomarkers of Aging Research RFA (NIH/NIA RFA AG-91-17), using the procedures of mathematical statistics, mathematical modeling, and advanced scientific visualization techniques to permit a statistically, as well as scientifically/biologically valid assessment of the gerontologic age of rodents of the genotype specified in the RFA using a panel of applicable biomarkers of aging. In order to test the effects of potential strategies and interventions, on the extension of the vigorous and the productive years of life, it is important that viable biomarkers of aging be developed. The development of biomarkers of aging is particularly important if a scientific intervention strategy is to be developed for humans.

在几乎所有的 已经研究的多细胞生物。 这个目的 建议是根据基于 啮齿动物模型。 特别是，该提案回应了请求 为了进行全面的统计分析，旨在将 作为该生物标志物的一部分进行的所有研究的结果 老化研究RFA（NIH/NIA RFA AG-91-17），使用的程序 数学统计，数学建模和高级科学 可视化技术允许统计以及 科学/生物学有效评估的老年学年 使用一组适用的面板在RFA中指定的基因型的啮齿动物 衰老的生物标志物。 为了测试潜在策略的影响 和干预措施，在剧烈和生产力的扩展方面 生命年，重要的是，可行的衰老生物标志物 发达。 尤其是衰老的生物标志物的发展 重要的是要制定科学干预策略 人类。