Autonomic and Vascular Mechanisms of Cardiovascular Risk in Women with Post-traumatic Stress Disorder (PTSD)

患有创伤后应激障碍 (PTSD) 的女性心血管风险的自主神经和血管机制

• 批准号: 10596476
• 负责人: Ida Tchuisseu Fonkoue
• 金额: $ 13.22万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596476
• 关键词: Address; Adult; Behavior; Biological Availability; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Chronic stress; Clinical Research; Clinical Sciences; Data; Development; Diagnosis; Disease; Doppler Ultrasound; Early Intervention; Endothelium; Environment; Estradiol; Estrogens; Female; Funding; Future; Generalized Anxiety Disorder; Goals; Grant; Growth; Health; High Risk Woman; Hormonal; Hormones; Hour; Human; Hypertension; Impairment; Inosine Dialdehyde; Intervention; Kidney; Knowledge; Lead; Leg; Link; Master of Science; Measures; Mediating; Menopause; Menstrual cycle; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Movement; Muscle; Nerve; Neuronal Dysfunction; Nightmare; Nitric Oxide; Outcome; Panic Disorder; Pathway interactions; Patients; Periodicals; Peripheral; Physiological; Physiology; Plasma; Play; Post-Traumatic Stress Disorders; Premenopause; Prevalence; Prevention strategy; Production; Psyche structure; Research; Research Personnel; Research Project Grants; Resources; Rest; Risk; Role; Severities; Sleep; Sleep Apnea Syndromes; Sleep disturbances; Sleeplessness; Stress; Surveys; Sympathetic Nervous System; Testing; Training; Translational Research; Trauma; Trauma Research; United States National Institutes of Health; Universities; Vascular Diseases; Vulnerable Populations; Woman; Women' s Health; Work; actigraphy; arterial stiffness; arterial tonometry; aspirate; blood pressure elevation; brachial artery; cardioprotection; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career development; comparison control; design; didactic education; experience; high risk; high risk population; improved; improvement on sleep; men; multidisciplinary; neural; poor sleep; programs; protective effect; renal artery; skills; stress disorder; therapy development; tonometry; trauma exposure; vascular abnormality; vasoconstriction; young woman

PROJECT SUMMARY The ultimate objective of this K01 proposal is to enable Dr. Ida Fonkoue to become an independent research investigator by 1) developing expertise in vascular, hormonal and sleep measures in humans; 2) acquiring scientific growth through a rigorous training plan, within an outstanding scientific environment that has a long tradition in translational vascular research; and 3) generating sufficient preliminary results to support an NIH R01 application. The candidate’s long-term goal is to build an NIH-funded research program in clinical and translational research in women’s health, studying derangements of vascular, neural and hormonal control, that contribute to the high rates of hypertension and cardiovascular disease (CVD) in women living with chronic stress exposure such as those with post-traumatic stress disorder (PTSD), generalized anxiety disorder or panic disorder. Over 7 million U.S. adults have PTSD, a disorder associated with a greater risk for hypertension and CVD. While healthy premenopausal women are relatively protected from CVD compared to men, a diagnosis of PTSD increases CVD risk in women by up to 3-fold. Understanding the mechanisms underlying CVD risk in women with PTSD is of paramount importance to develop intervention strategies aiming at protecting the future health of this vulnerable population. Based on our preliminary data, the working hypothesis of this project is that: PTSD inhibits nitric oxide bioavailability, resulting in decreased endothelial function, increased arterial stiffness and increased sympathetic activation; and that these changes are exacerbated by low estradiol levels and sleep disturbances. Aim 1 will identify alterations in SNS activity in premenopausal women with PTSD and determine if these alterations are a function of low E2 levels and sleep disturbances. Aim 2 will Identify alterations in vascular function in premenopausal women with PTSD and determine if these alterations are a function of low E2 levels and sleep disturbances. Emory University, where the PI’s entire mentoring team is located, boasts an intellectually rich research environment whose resources will be used to carry out the proposed research, including an NIH-funded Georgia Clinical and Translational Science Alliance (GA CTSA). During this K01 award, the PI will devote 75% effort to this project and career development-related activities as highlighted in her four years training and research plans. She will complete a Master of Science in Clinical Research offered by the GA CTSA and prepare future career development grant submission. This research project, combined with multidisciplinary mentorship, didactic education, and practical experience, will provide Dr. Fonkoue with the training and skills to become a successful independent investigator.

项目摘要 该K01提案的最终目标是使Ida Fonkoue博士成为一项独立研究 研究人员1）在人类的血管，荷尔蒙和睡眠措施方面发展专业知识； 2）征收 通过严格的培训计划的科学发展，在一个杰出的科学环境中 翻译血管研究的传统； 3）产生足够的初步结果以支持NIH R01应用程序。候选人的长期目标是在临床和 妇女健康的转化研究，研究血管，神经和激素控制的进化， 这有助于慢性女性的高血压和心血管疾病（CVD）的高率 压力暴露，例如患有创伤后应激障碍（PTSD），广义动画障碍或 恐慌症。 超过700万美国成年人患有PTSD，这种疾病与高血压风险更大相关 CVD。与男性相比 PTSD的妇女的CVD风险增加了3倍。了解CVD风险的机制 具有PTSD的妇女对于制定干预策略旨在保护未来至关重要 这个脆弱人群的健康。根据我们的初步数据，该项目的工作假设是 那就是：PTSD抑制一氧化氮生物利用度，导致内皮功能降低，动脉增加 僵硬和同情激活增加；并且这些变化因低雌二醇水平而加剧 和睡眠障碍。 AIM 1将确定具有PTSD和PTSD前妇女的社交媒体活动的变化 确定这些改变是否是低E2水平和睡眠障碍的函数。 AIM 2将确定 PTSD的绝经前女性血管功能的改变，并确定这些改变是否为 低E2水平和睡眠障碍的功能。 PI整个心理团队所在的埃默里大学（Emory University）拥有一项智力丰富的研究 其资源将用于进行拟议研究的环境，包括NIH资助 佐治亚州临床和转化科学联盟（GA CTSA）。在此K01奖中，PI将投入75％ 这项项目和职业发展相关的活动的努力是她的四年培训和 研究计划。她将完成GA CTSA和 准备未来的职业发展赠款提交。该研究项目与多学科结合 识别，教学教育和实践经验，将为Fonkoue博士提供培训和技能 成为成功的独立调查员。