Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
麻醉手术刺激下正常衰老和阿尔茨海默病的代谢组学特征
基本信息
- 批准号:10556362
- 负责人:
- 金额:$ 78.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-15 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:AD transgenic miceAftercareAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer&aposs disease patientAnesthesia proceduresAnimal BehaviorAnimal ModelAnimalsAnti-Inflammatory AgentsApoptoticBloodBrainBrain regionClinicClinicalClinical ProtocolsCyclosporineDevelopmentDiffusion Magnetic Resonance ImagingElectron MicroscopeEvaluationFoundationsFunctional Magnetic Resonance ImagingGluconeogenesisGlucoseGoalsHomeostasisHourHumanImageImmunochemistryImpairmentIndividualInterventionKnock-outLabelLongevityMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMetabolicMethodsMitochondriaMonitorMusNon-Invasive DetectionOnset of illnessOperative Surgical ProceduresOrganPathogenesisPathway interactionsPatientsPredispositionPreventiveProceduresProtocols documentationRestSerumStimulusTechnologyTestingTimeTissue HarvestingTissuesTrainingTransgenic OrganismsTranslatingValidationVitamin K 2Wild Type Mousearmbehavior testbrain tissuecohortdesignin vivoin vivo imagingin vivo magnetic resonance spectroscopymetabolomicsmitochondrial dysfunctionmorris water mazemouse modelmultimodalitymyelinationneuroinflammationnon-invasive monitornoninvasive diagnosisnormal agingnovelsuccesstool
项目摘要
We propose to quantify aging- and AD-associated brain and blood metabolic changes through ex vivo and in
vivo multimodality MR measurements in mouse models after an AD-promoting stimuli, anesthesia-surgery,
with-or-without preventive, protective treatments. This approach recognizes that AD onset, pathogenesis and
progression must produce alterations in the overall metabolic status, or metabolomics, of brain and other
organs in AD patients, as compared with normal homeostasis in healthy individuals, and our understanding of
the urgent need to develop non-invasive AD diagnosis tools. In the three proposed Aims, we will (1)
Characterize age-associated metabolomic changes ex vivo using tissues from different brain regions and blood
serum obtained from wild-type and AD mice after administration of anesthesia-surgery stimuli; (2) Develop
multimodality in vivo MR protocols for non-invasive evaluations of age- and AD-associated brain metabolic
changes induced by anesthesia-surgery stimuli; and (3) Investigate the effect of an AD protective intervention
on metabolomic changes after administration of anesthesia-surgery stimuli. The success of this project will
lead us to establish translational protocols that can guide and interpret multimodality in vivo MR imaging results
by obtaining accurate ex vivo MRS, EM, and immunochemistry measurements in the proposed animal models,
and translating these findings into clinical protocols for human AD non-invasive diagnosis.
我们建议通过离体和IN量化与衰老和广告相关的大脑和血液代谢变化
促进AD刺激刺激,麻醉手术后,小鼠模型中的体内多模态测量值
带有预防性,保护性治疗。这种方法认识到AD发作,发病机理和
进展必须在大脑和其他的总体代谢状态或代谢组学上产生改变
与健康个体的正常稳态相比,广告患者的器官以及我们对
迫切需要开发非侵入性AD诊断工具。在提议的三个目标中,我们将(1)
表征与年龄相关的代谢组学变化,使用来自不同大脑区域的组织和血液
进行麻醉性手术刺激后,从野生型和AD小鼠获得的血清; (2)发展
多模式在体内MR方案中,用于对年龄和广告相关脑代谢的非侵入性评估
麻醉性手术刺激引起的变化; (3)研究AD保护性干预的效果
对麻醉性手术刺激后的代谢组变化。这个项目的成功将
引导我们建立可以指导和解释体内MR成像结果多模式的转化方案
通过在拟议的动物模型中获得准确的离体MRS,EM和免疫化学测量值
并将这些发现转化为人类AD非侵入性诊断的临床方案。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Leo L Cheng其他文献
Leo L Cheng的其他文献
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{{ truncateString('Leo L Cheng', 18)}}的其他基金
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
麻醉手术刺激下正常衰老和阿尔茨海默病的代谢组学特征
- 批准号:
10350570 - 财政年份:2021
- 资助金额:
$ 78.67万 - 项目类别:
Upgrade of Console for 600 MHz MR Spectrometer
600 MHz 磁共振波谱仪控制台升级
- 批准号:
9272595 - 财政年份:2017
- 资助金额:
$ 78.67万 - 项目类别:
Development of Metabolomic and Molecular Probes for Prostate Cancer Assessment
用于前列腺癌评估的代谢组学和分子探针的开发
- 批准号:
8205493 - 财政年份:2011
- 资助金额:
$ 78.67万 - 项目类别:
Development of Metabolomic and Molecular Probes for Prostate Cancer Assessment
用于前列腺癌评估的代谢组学和分子探针的开发
- 批准号:
8332771 - 财政年份:2011
- 资助金额:
$ 78.67万 - 项目类别:
Detection of Lung Cancer Risks for Serum Metabolomics
血清代谢组学检测肺癌风险
- 批准号:
7787700 - 财政年份:2010
- 资助金额:
$ 78.67万 - 项目类别:
Detection of Lung Cancer Risks for Serum Metabolomics
血清代谢组学检测肺癌风险
- 批准号:
8010636 - 财政年份:2010
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
7914796 - 财政年份:2009
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
8530894 - 财政年份:2006
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
7893739 - 财政年份:2006
- 资助金额:
$ 78.67万 - 项目类别:
Characterizing Prostate Cancer By ex vivo MRS Signatures
通过离体 MRS 特征表征前列腺癌
- 批准号:
9248210 - 财政年份:2006
- 资助金额:
$ 78.67万 - 项目类别:
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