Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk Program

环境暴露和癌症风险计划队列协调中心

基本信息

批准号：
10557188
负责人：
Kristen Mary Chossek Malecki
金额：
$ 67.99万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10557188
关键词：
Acceleration Address Attention Behavioral Biological Cancer Biology Cancer Burden Cancer Center Cancer Etiology Cancer Science Cessation of life Chemicals Cohort Studies Collaborations Common Data Element Communication Communities Data Data Science Deposition Development Ensure Environment Environmental Exposure Environmental Health Environmental Impact Environmental Risk Factor Environmental Science Exclusion Fostering Genetic Goals Individual Infrastructure Investments Knowledge Leadership Malignant Neoplasms Medical Metadata Mission Morbidity - disease rate Participant Population Population Heterogeneity Prevention Process Productivity Public Health Practice Reproducibility of Results Research Research Activity Research Design Research Personnel Research Project Grants Resource Sharing Resources Risk Role Sampling Science Scientific Advances and Accomplishments Secure Source Structure Technology Toxicology Training Translations Trust United States United States National Institutes of Health Universities Wisconsin advocacy organizations cancer epidemiology cancer health disparity cancer risk career cohort community engagement data dissemination data sharing data submission environment related cancer epidemiology study evidence base experience health disparity populations innovation innovative technologies member mortality multidisciplinary outreach prevent programs prospective repository structural determinants web site webinar

项目摘要

While scientific and medical advances have dramatically increased our ability to prevent, detect and treat cancer, gaps remain regarding the impact of environmental exposures—particularly chemical and physical factors—on cancer risk. The overarching goal of this application is to build collaborative infrastructure and facilitate transdisciplinary scientific research for enhancing our understanding of environmental exposures influencing cancer etiology, and the genetic, behavioral, and structural factors that modify risk across diverse populations. We propose to serve as the Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk (CEECR) Program. Our mission is to provide intellectual leadership and logistical and collaborative infrastructure for the CEECR program by integrating efforts across the CEECR cohorts, facilitating research activities, identifying opportunities for cross-CEECR collaboration, and disseminating research findings through partnerships with stakeholders. We will draw upon extensive experience coordinating large-scale consortia, conducting prospective cancer epidemiology studies, and engaging with community partners to support the CEECR Program. We will facilitate cooperation across the CEECR cohorts to achieve their UG3/UH3 milestones and realize their full potential as an integrated sustained powerful source of knowledge for characterizing the impact of environmental exposures on cancer risk. Specific Aims include: 1) providing intellectual leadership and multidisciplinary scientific expertise, establishing a governance structure, and identifying opportunities to catalyze cross-cohort collaboration; 2) assisting with the identification of common data elements and the integration of research efforts regarding biological samples and innovative technologies; 3) facilitating innovative transdisciplinary research by developing evidence-based infrastructure to support collaboration, coordination, communication, outreach and engagement, and career enhancement; and 4) fostering resource sharing by CEECR members with external researchers and stakeholders—including the deposition of data in NIH repositories—to accelerate research and move findings towards translation and prevention. Our multidisciplinary team includes experts in cancer epidemiology, environmental health, team science, cancer health disparities, cancer biology, toxicology, data science, applied public health practice, outreach/community engagement, and research administration. The University of Wisconsin Carbone Cancer Center provides the ideal environment for supporting the Coordinating Center due to its resources and established relationships with local and national research and advocacy organizations. The CEECR Coordinating Center will use multiple innovative approaches to leverage program members’ common passion for elucidating the role of environmental factors in cancer etiology, provide expanded opportunities for collaboration, and enable the CEECR Program to bring about substantive reductions in the cancer burden paying special attention to populations historically excluded from the full benefits of scientific advances.

虽然科学和医学的进步极大地提高了我们预防、检测和治疗的能力对于癌症，关于环境暴露的影响仍然存在差距，特别是化学和物理暴露该应用程序的首要目标是建立协作基础设施和促进跨学科科学研究，以增强我们对环境暴露的理解癌症病因学，以及影响不同风险的遗传、行为和结构因素我们建议充当环境暴露队列协调中心癌症风险 (CEECR) 计划是提供智力领导和后勤保障。通过整合 CEECR 群体的努力，为 CEECR 计划提供协作基础设施，促进研究活动，确定跨 CEECR 合作的机会，并传播我们将利用与利益相关者合作的研究成果。协调大型联盟，进行前瞻性癌症流行病学研究，并与我们将促进 CEECR 群体之间的合作。实现 UG3/UH3 里程碑并充分发挥其作为综合持续强大来源的潜力描述环境暴露对癌症风险影响的知识具体目标包括： 1）提供智力领导和多学科科学专业知识，建立治理结构，并确定促进跨群体合作的机会；2）协助识别；共同数据元素的整合以及有关生物样本和创新的研究工作的整合 3）通过开发基于证据的基础设施促进创新的跨学科研究支持协作、协调、沟通、外展和参与以及职业提升； 4) 促进 CEECR 成员与外部研究人员和利益相关者共享资源，包括将数据存储在 NIH 存储库中——加速研究并将发现转化为成果我们的多学科团队包括癌症流行病学、环境健康方面的专家。科学、癌症健康差异、癌症生物学、毒理学、数据科学、应用公共卫生实践、外展/社区参与和研究管理。由于其资源和能力，中心为支持协调中心提供了理想的环境。与地方和国家研究和倡导组织建立了关系。协调中心将采用多种创新方法来激发计划成员的共同热情为了阐明环境因素在癌症病因学中的作用，为合作，并使 CEECR 计划能够实质性减少癌症负担特别关注历史上被排除在科学进步的全部利益之外的人群。