Designer Molecular Probes for Biomedical Applications

用于生物医学应用的设计分子探针

• 批准号: 10552841
• 负责人: Ivan Julian Dmochowski
• 金额: $ 25万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10552841
• 关键词: Anesthesiology; Anesthetics; Area; Award; Awareness; Bioinorganic Chemistry; Biological; Biology; Biomedical Research; Book Chapters; Books; Brain; Cell physiology; Cells; Chemicals; Chemistry; Collaborations; Communities; Contrast Media; Development; Diabetes Mellitus; Diagnosis; Disease; Doctor of Philosophy; Education and Outreach; Fluorescent Probes; Funding; General Anesthesia; General anesthetic drugs; Genomics; Goals; Image; Immersion; Interdisciplinary Study; Laboratories; Legal patent; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Mentors; Messenger RNA; Molecular; Molecular Probes; NMR Spectroscopy; Nerve Degeneration; Oligonucleotide Probes; Oligonucleotides; Organ; Organic Chemistry; Peer Review; Pennsylvania; Play; Postdoctoral Fellow; Process; Productivity; Proteins; Publications; RNA; Radiology Specialty; Regulation; Research; Role; Science; Scientist; Services; Specificity; Study Section; Technology; Tissues; Training; Universities; Xenon; base; biophysical chemistry; biophysical techniques; career; chemical synthesis; community building; complex biological systems; design; disease diagnosis; engineering design; experience; faculty mentor; graduate student; human disease; improved; in vivo; innovation; molecular imaging; nanoscale; novel; professor; programs; spatiotemporal; tool; transcriptome; transcriptomics; undergraduate student

Project Summary/Abstract: The PI is the Alan MacDiarmid Term Professor of Chemistry at the University of Pennsylvania (UPenn), where in 2003 he launched a multidisciplinary research program developing molecular probes that have led to breakthroughs in Chemical Biology, Radiology, Cellular Genomics/Transcriptomics, and Anesthesiology. In the course of this research, the PI has mentored 9 postdoctoral fellows, 35 graduate students, and 50 undergraduates, with many winning national awards and most graduates pursuing careers in science and biomedicine. The PI's research draws on formal training in supramolecular organic chemistry (Harvard-Mainz), bioinorganic and biophysical chemistry (Caltech, Ph.D.), and biology/biomolecular imaging (Caltech, postdoc). The PI's immersion for the past 19 years in the biomedical research enterprise at UPenn has burnished this experience. Through key collaborations, the PI has tackled significant biomedical research questions, using the tools of chemical synthesis, protein and oligonucleotide chemistry, and bioanalytical chemistry. The PI's 105 peer-reviewed publications, 7 patents, 4 edited books and contributed book chapters highlight a track record of productivity, innovation, impact, and dissemination in the development and application of chemical tools for biomedical research. The PI's service, including current membership on the SBCA study section, confirms a strong commitment to scientific review, education, outreach, community building, and junior faculty mentoring. This MIRA award extends the PI's highly successful GM-funded research in three program areas: 1) molecular imaging using xenon- based MRI contrast agents; 2) cellular transcriptome-in-vivo-analysis and mRNA regulation using light-activated oligonucleotide probes; and, 3) elucidation of general anesthetic-protein interactions with novel fluorescent probes, ultrasensitive 129Xe NMR spectroscopy, and other biophysical methods. Significant goals of the next five-year period are to refine these probe- based technologies with world-class research-collaborators at UPenn and establish high-value probes that can be disseminated broadly to the biomedical research community. Collectively, these tools will advance our molecular understanding of normal biological/biomedical processes (including general anesthesia), and provide avenues for improved diagnosis and treatment of many human diseases, including cancer, neurodegeneration, and diabetes.

项目摘要/摘要： PI是宾夕法尼亚大学的艾伦·麦克迪亚米德（Alan MacDiarmid）学期教授 （UPENN），在2003年，他启动了一项跨学科研究计划，开发了分子 导致化学生物学，放射学，细胞的突破的探针 基因组学/转录组学和麻醉学。在这项研究的过程中，PI有 指导了9名博士后研究员，35名研究生和50名本科生，其中许多 赢得国家奖项和大多数从事科学和生物医学职业的毕业生。这 PI的研究借鉴了超分子有机化学（哈佛 - 梅兹）的正式培训， 生物无机和生物物理化学（Caltech，Ph.D.）和生物学/生物分子成像 （加州理工学院，博士后）。 PI在过去19年中沉浸在生物医学研究中 Upenn的Enterprise振作了这一经历。通过关键合作，PI有 使用化学合成，蛋白质的工具解决了重要的生物医学研究问题 和寡核苷酸化学和生物分析化学。 PI的105个同行评审 出版物，7份专利，4本编辑书籍，并贡献了书籍章节，重点介绍了 生产力，创新，影响和传播在开发和应用中 生物医学研究的化学工具。 PI的服务，包括当前成员 SBCA研究部分，确认对科学审查，教育，外展， 社区建设和初级教师指导。该MIRA奖延长了PI的高度 成功在三个程序领域获得了GM资助的研究：1）使用Xenon-分子成像 基于MRI对比剂； 2）体内分析和mRNA调节的细胞转录组 使用光激活的寡核苷酸探针； 3）阐明全身麻醉蛋白 与新型荧光探针，超敏感的129xE NMR光谱和其他相互作用 生物物理方法。接下来五年的重大目标是完善这些调查 - 与UPenn的世界一流研究合作者的基于世界一流的研究，并建立高价值 可以大致传播到生物医学研究界的探针。共同 这些工具将提高我们对正常生物/生物医学过程的分子理解 （包括全身麻醉），并提供改善诊断和治疗的途径 许多人类疾病，包括癌症，神经变性和糖尿病。