The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers
下一代创新型心血管临床/转化研究人员
基本信息
- 批准号:10548209
- 负责人:
- 金额:$ 11.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAdultAdvisory CommitteesAssessment toolBiomedical EngineeringCardiologyCardiovascular DiseasesCardiovascular systemChildhoodChildhood diabetesCircadian desynchronyClinicalCollaborationsCoupledDedicationsDependenceDevelopmentDiabetes MellitusDiabetic NephropathyDyslipidemiasEducationEndocrinologyEnvironmentFunctional disorderFutureGenerationsGoalsGrantHypertensionInstitutionInsulinInsulin ResistanceInsulin-Dependent Diabetes MellitusLeadLeadershipLearningLinkLiteratureLongevityMedicalMedicineMentorsMentorshipMinority GroupsNational Heart, Lung, and Blood InstituteNon-Insulin-Dependent Diabetes MellitusObesityObesity EpidemicOperative Surgical ProceduresParentsPhysiciansPolycystic Ovary SyndromePositioning AttributePrevalencePrevention ResearchRadiology SpecialtyResearchResearch PersonnelResearch ProposalsResearch TrainingResourcesRisk AssessmentRisk FactorsRisk ReductionScientistSleep Apnea SyndromesStructure of beta Cell of isletTimeTrainingUnderrepresented MinorityUnderserved PopulationUnited States National Institutes of HealthYouthcardiovascular disorder preventioncardiovascular disorder riskcareercomorbidityexperiencefitnessimprovedineffective therapiesinnovationinsulin dependent diabetes mellitus onsetinsulin secretionmedical schoolsminority childrenmortalitynext generationobesity in childrenpatient oriented researchprogramsresponsible research conductskillstimelinetranslational scientisttrend
项目摘要
Project Summary/Abstract
My career focus is research and educational efforts to reduce early cardiovascular disease (CVD) risk
factors. Obesity, diabetes, and underlying insulin resistance (IR) are major contributors to CVD, accelerated by
the current pediatric obesity epidemic. Unique factors in youth with type 2 diabetes (T2D) lead to early insulin
dependence and progression of co-morbidities that accelerate CVD and mortality, and typical adult T2D
treatments are ineffective in youth. The mechanism of IR in T1D is also unclear, limiting our ability to reduce
CVD risk in T1D. Moreover, current CV-assessment tools are often too invasive for youth. My prior research
training, initial leadership experiences and collaborations with cardiology, bioengineering, and radiology
provide the skills and combined expertise to address these critical voids. An NHLBI K24 grant will train me to
better provide mentorship in high-impact POR to CVD-focused physician-scientists of exceptional potential and
nurture a diverse pipeline of new investigators. My career goals are to: 1) Better understand early precursors
of CVD in the underserved population of youth with obesity/diabetes 2) Develop non-invasive approaches to
CVD risk-assessment tolerable to youth 3) Develop new medical and/or surgical treatments to reduce CVD risk
in youth and 4) Learn how to best engage, motivate and train a diverse set of emerging researchers in cutting-
edge POR. Support as a K24 scholar will provide dedicated time to benefit from the exceptional POR
mentoring and leadership training resources of our campus and beyond, and focus on these goals.
My K24 application includes an overview of: 1) My skills, record and dedication to mentoring in POR; 2) A
strategy to reduce administrative/clinical obligations and focus on mentoring; 3) An impactful, cutting-edge K24
POR proposal with numerous opportunities for trainees; 4) A strategy for integrating expert collaborators as a
K24 Advisory Committee to deliver superior and cohesive training, mentoring and oversight of junior
colleagues and to assure a pipeline of future trainees; 5) Evidence of a robust pool of protected early career
POR investigators to benefit from K24 support; 6) A timeline for training in responsible conduct of research; 7)
Evidence of the collaborator, institutional and environmental support underlying my POR program and for the
K24 proposal.
My Aims as an NHLBI K24 Scholar are to: 1) Strengthen mentoring of a diverse set of early career
investigators to create a pipeline of well-trained physician-scientists focused on CVD POR. Rationale: The
proposed training plan offers exceptional support, environment and expertise for creating a POR career in CVD
prevention. I will integrate my current mentoring skills with those gained from the K24, to deliver the highest
quality mentorship. 2). Build upon my CVD risk-reduction POR in youth-onset obesity/diabetes.
Rationale: Given K24 support, I am positioned to enhance the quality and breadth of our POR research, and
thereby improve the lives of the growing numbers of youth with obesity and diabetes.
项目概要/摘要
我的职业重点是降低早期心血管疾病 (CVD) 风险的研究和教育工作
因素。肥胖、糖尿病和潜在的胰岛素抵抗 (IR) 是 CVD 的主要原因,而这些因素又加速了 CVD 的发生
当前小儿肥胖流行。患有 2 型糖尿病 (T2D) 的青少年的独特因素导致早期使用胰岛素
加速 CVD 和死亡率的合并症的依赖性和进展,以及典型的成人 T2D
治疗对青少年无效。 T1D 中 IR 的机制也不清楚,限制了我们减少 T1D 的能力
T1D 的 CVD 风险。此外,当前的简历评估工具对于年轻人来说往往过于具有侵入性。我之前的研究
培训、初步领导经验以及与心脏病学、生物工程和放射学的合作
提供技能和综合专业知识来解决这些关键空白。 NHLBI K24 补助金将训练我
更好地为具有特殊潜力和能力的专注于 CVD 的医师科学家提供高影响力的 POR 指导
培养多元化的新研究人员。我的职业目标是:1)更好地理解早期先驱
2) 开发非侵入性方法
青少年可耐受的 CVD 风险评估 3) 开发新的医疗和/或手术治疗方法以降低 CVD 风险
4)学习如何最好地吸引、激励和培训不同的新兴研究人员
边沿 POR。作为 K24 学者的支持将提供专门的时间来从特殊的 POR 中受益
我们校园内外的指导和领导力培训资源,并专注于这些目标。
我的 K24 申请包括以下概述: 1) 我在 POR 指导方面的技能、记录和奉献精神; 2)A
减少行政/临床义务并注重指导的战略; 3) 具有影响力的尖端 K24
POR 提案为学员提供了大量机会; 4) 将专家合作者整合为一个战略
K24 咨询委员会为初级学生提供卓越且有凝聚力的培训、指导和监督
同事并确保未来学员的渠道; 5) 有证据表明有大量受保护的早期职业
POR 调查员将从 K24 支持中受益; 6) 负责任的研究行为培训时间表; 7)
我的 POR 计划的合作者、机构和环境支持的证据以及
K24提案。
作为 NHLBI K24 学者,我的目标是: 1) 加强对各种早期职业生涯的指导
研究人员建立了一批训练有素的医师科学家队伍,专注于 CVD POR。理由:
拟议的培训计划为在 CVD 领域创建 POR 职业提供卓越的支持、环境和专业知识
预防。我会将我目前的指导技能与 K24 中获得的技能相结合,以提供最高的指导
高质量的指导。 2)。以我针对青年肥胖/糖尿病的 CVD 风险降低 POR 为基础。
理由:在 K24 的支持下,我有能力提高 POR 研究的质量和广度,并且
从而改善越来越多患有肥胖症和糖尿病的青少年的生活。
项目成果
期刊论文数量(16)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Metabolic outcomes of surgery in youth with type 2 diabetes.
2 型糖尿病青年手术的代谢结果。
- DOI:10.1016/j.sempedsurg.2020.150893
- 发表时间:2020
- 期刊:
- 影响因子:1.7
- 作者:Shah,AmyS;Nadeau,KristenJ;Helmrath,MichaelA;Inge,ThomasH;Xanthakos,StavraA;Kelsey,MeganM
- 通讯作者:Kelsey,MeganM
A Model of Adolescent Sleep Health and Risk for Type 2 Diabetes.
- DOI:10.1007/s11892-020-01373-1
- 发表时间:2021-01-15
- 期刊:
- 影响因子:4.2
- 作者:Simon SL;Higgins J;Melanson E;Wright KP Jr;Nadeau KJ
- 通讯作者:Nadeau KJ
Early Childhood Caries in Indigenous Communities.
- DOI:10.1542/peds.2021-051481
- 发表时间:2021-06
- 期刊:
- 影响因子:8
- 作者:Holve S;Braun P;Irvine JD;Nadeau K;Schroth RJ;AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON NATIVE AMERICAN CHILD HEALTH AND SECTION ON ORAL HEALTH, CANADIAN PAEDIATRIC SOCIETY FIRST NATIONS, INUIT, AND MÉTIS HEALTH COMMITTEE
- 通讯作者:AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON NATIVE AMERICAN CHILD HEALTH AND SECTION ON ORAL HEALTH, CANADIAN PAEDIATRIC SOCIETY FIRST NATIONS, INUIT, AND MÉTIS HEALTH COMMITTEE
Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children.
- DOI:10.1146/annurev-med-042120-012033
- 发表时间:2022-01-27
- 期刊:
- 影响因子:10.5
- 作者:
- 通讯作者:
Obstructive sleep apnea and early weight loss among adolescents undergoing bariatric surgery.
- DOI:10.1016/j.soard.2020.12.003
- 发表时间:2021-04
- 期刊:
- 影响因子:0
- 作者:Kaar JL;Morelli N;Russell SP;Talker I;Moore JM;Inge TH;Nadeau KJ;Hawkins SMM;Aloia MS;Simon SL
- 通讯作者:Simon SL
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KRISTEN Jane NADEAU其他文献
KRISTEN Jane NADEAU的其他文献
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{{ truncateString('KRISTEN Jane NADEAU', 18)}}的其他基金
The Next Generation of Innovative Cardiovascular Clinical/Translational Researchers
下一代创新型心血管临床/转化研究人员
- 批准号:
10327672 - 财政年份:2019
- 资助金额:
$ 11.49万 - 项目类别:
RISE: The Restoring Insulin Secretion Pediatric Medication Study
RISE:恢复胰岛素分泌的儿科药物研究
- 批准号:
8893072 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
Beta-Cell Rescue in Youth with New Onset T2DM
β 细胞拯救新发 T2DM 青少年
- 批准号:
8336912 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
RISE: The Restoring Insulin Secretion Pediatric Medication Study
RISE:恢复胰岛素分泌的儿科药物研究
- 批准号:
9109755 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
Beta-Cell Rescue in Youth with New Onset T2DM
β 细胞拯救新发 T2DM 青少年
- 批准号:
8536282 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
Beta-Cell Rescue in Youth with New Onset T2DM
β 细胞拯救新发 T2DM 青少年
- 批准号:
8248477 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
Beta-cell Rescue in Youth with New Onset T2DM
β 细胞拯救新发 T2DM 青少年
- 批准号:
8331068 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
RISE: The Restoring Insulin Secretion Pediatric Medication Study
RISE:恢复胰岛素分泌的儿科药物研究
- 批准号:
8703096 - 财政年份:2011
- 资助金额:
$ 11.49万 - 项目类别:
Insulin Resistance In Adolescents With Diabetes: A New Frontier For Cardiovascula
青少年糖尿病患者的胰岛素抵抗:心血管的新领域
- 批准号:
8074154 - 财政年份:2010
- 资助金额:
$ 11.49万 - 项目类别:
EXERCISE CAPACITY IN PEDIATRIC OBESITY AND TYPE 2 DIABETES
儿童肥胖和 2 型糖尿病患者的运动能力
- 批准号:
7605088 - 财政年份:2007
- 资助金额:
$ 11.49万 - 项目类别:
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