Mechanisms of cardiovascular disease

心血管疾病的机制

• 批准号: 10546496
• 负责人: Richard N Kitsis
• 金额: $ 20.76万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10546496
• 关键词: Cardiovascular Diseases

This is an application for a new T32 Ruth L. Kirschstein Institutional National Research Service Award entitled Mechanisms of Cardiovascular Disease. The Albert Einstein College of Medicine, one of the first institutions in the nation to establish a formal Molecular Cardiovascular Biology Program in 1987, has a long tradition of cardiovascular research training. Contemporary biomedical science permits the integration of genetics, epigenetics, molecular biology, physiology, model systems research, and epidemiology to drive progress in understanding of cardiovascular disease. Through these modalities, we can begin to understand the precise molecular mechanisms that predispose to and are involved in complex processes such as congenital heart disease, atherosclerosis, ischemic heart disease, and heart failure. Our program's overall structure includes 11 trainers representing 6 different departments, with areas of thematic focus in 1) Myocardium – Injury and Aging, 2) Vascular Development and Disease, and 3) Metabolism – Cardiovascular Risk. The mission of this program is to provide the next generation of investigators, including both pre- and postdoctoral trainees, with state-of-the art concepts, experiences, and skills required to initiate and sustain successful long-term independent careers in cardiovascular research. As a result of this program, dialogues among scientists working in fundamental areas of biology, basic cardiovascular scientists, and clinical cardiologists will be enhanced, leading to productive collaborations and cutting-edge research. This program brings our institution's considerable depth, rigorous scientific approach, and tradition of innovation to bear on important and highly prevalent cardiovascular problems.

这是新 T32 Ruth L. Kirschstein 国家研究机构的申请 题为“阿尔伯特·爱因斯坦心血管疾病机制”的服务奖。 医学院是全国最早建立正式医学院的院校之一 分子心血管生物学项目于1987年设立，具有悠久的传统 当代生物医学科学允许心血管研究培训。 遗传学、表观遗传学、分子生物学、生理学、模型系统的整合 研究和流行病学，以推动对心血管疾病的了解取得进展。 通过这些方式，我们可以开始了解精确的分子 倾向于并参与复杂过程的机制，例如 先天性心脏病、动脉粥样硬化、缺血性心脏病和心力衰竭。 我们项目的整体结构包括代表 6 个不同部门的 11 名培训师， 主题重点领域为 1) 心肌 – 损伤和衰老，2) 血管 发育与疾病，以及 3) 新陈代谢 – 心血管风险。 该计划旨在培养下一代研究人员，包括预审和 博士后实习生，拥有最先进的概念、经验和技能 启动并维持心血管研究领域成功的长期独立职业生涯。 该计划的结果是，在以下基本领域工作的科学家之间进行了对话： 生物学、基础心血管科学家和临床心脏病学家将得到加强， 该计划带来了富有成效的合作和前沿研究。 机构相当的深度、严谨的科学方法和创新传统 解决重要且高度普遍的心血管问题。