Wide-field corneal microlayer tomography for keratoconus

圆锥角膜的广角角膜微层断层扫描

• 批准号: 10543502
• 负责人: Mohamed Fadel Abou Shousha
• 金额: $ 40.36万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10543502
• 关键词: Address; Anatomy; Area; Biological Markers; Biomechanics; Blindness; Clinical; Computer software; Consensus; Control Groups; Cornea; Cross-Sectional Studies; Custom; Data; Descriptor; Detection; Devices; Diagnosis; Diagnostic; Disease; Disease Progression; Early Diagnosis; Early treatment; Elements; Epithelium; FDA approved; Foundations; Goals; Image; Imaging technology; Incidence; Individual; Keratoconus; Keratoplasty; Knowledge; Lateral; Maps; Measurement; Measures; Methods; Optics; Outcome; Pathogenesis; Patients; Peripheral; Population; Process; Property; Public Health; Research Design; Resolution; Scanning; Secondary to; Shapes; Signal Transduction; Structure; Surface; System; Technology; Testing; Thick; Time; United States; clinical imaging; corneal epithelium; crosslink; design; diagnostic technologies; experimental study; image processing; imaging modality; improved; indexing; interest; new technology; prevent; prototype; simulation; structural imaging; success; tomography; tool; young adult

PROJECT SUMMARY The long-term goal of this project is to improve diagnosis and management of keratoconus. The efficacy of corneal crosslinking for progressive keratoconus has generated interest in detecting the disease at an earlier stage in hopes of preventing progression leading to vision loss. Yet, there is currently no clinical evidence supporting the benefits of early treatment of keratoconus with crosslinking. The primary barrier in designing studies that address this question is the lack of diagnostic technology to identify keratoconus in the early stages. The project addresses this technological need. Current keratoconus diagnosis relies primarily on measurements of corneal shape. Since shape changes are secondary to microstructural alterations, a method to image the corneal microstructure could enable detection of keratoconus at an earlier stage. Alterations in the corneal epithelium and Bowman’s layer are among the first histophatologic signs of keratoconus. Our goal is to develop the first widefield OCT imaging modality to quantify structural and optical alterations of the epithelium and Bowman’s layer from the center to the periphery of the cornea. The technology will then be used to prove that alterations in Bowman’s layer and epithelium can be quantified across the entire cornea in keratoconus subjects. The project has two specific aims: Aim 1: To develop Widefield Corneal Microlayer Tomography (wCMT). The technology is based on high-resolution OCT combined with a new beam scanning approach to enable widefield imaging of the cornea. We will develop OCT image processing tools to generate the first volumetric thickness and optical scattering maps of the epithelium and Bowman’s layer over the entire cornea. The system and software will be tested on healthy and keratoconus subjects. Aim 2: To map the alterations of Bowman’s layer and epithelium over the entire cornea with wCMT in keratoconus. We will prove that wCMT can quantify alterations in Bowman’s layer and epithelium from the center to the periphery of the cornea. Data acquired on control subjects and patients with early-stage to moderate keratoconus will be used to prove that wCMT can detect alterations in Bowman’s layer and epithelium from the early stage of the disease. In the long term, the technology will have an important positive impact as it lays the foundation for the discovery of structural biomarkers that will enable the detection of keratoconus at an earlier stage.

项目摘要 该项目的长期目标是改善角核的诊断和管理。 角膜交联的效率对进行性角膜结构引起了人们对 在较早的阶段检测疾病，以期防止进展 损失。但是，目前尚无临床证据支持早期治疗的好处 圆锥角膜与交联。设计解决此问题的研究的主要障碍 问题是缺乏诊断技术来识别早期阶段的圆锥角膜。这 项目解决了这一技术需求。 当前的圆锥角膜诊断主要取决于角膜形状的测量。从形状开始 变化是继发于微观结构改变的，这是一种成像角膜的方法 微观结构可以在较早的阶段检测圆锥角膜。改变 角膜上皮和Bowman的层是第一个组织摄道的迹象 角膜结构。我们的目标是开发第一个广阔的OCT成像方式来量化 从中心到鲍曼的结构和光学改变。 角膜周围。然后，该技术将用于证明鲍曼的改变 可以在圆锥角膜受试者的整个角膜上量化层和上皮。 该项目有两个具体的目标： 目标1：开发广阔的角膜微层层造影（WCMT）。该技术是 基于高分辨率OCT与新的光束扫描方法相结合以启用 角膜的广阔菲尔德成像。我们将开发OCT图像处理工具来生成 上皮和鲍曼层的第一卷厚度和光学散射图 整个角膜。该系统和软件将对健康和角膜核对受试者进行测试。 目标2：绘制鲍曼层和上皮在整个角膜上的变化 与圆锥角膜中的WCMT。我们将证明WCMT可以量化鲍曼的变化 从中心到角膜周围的层和上皮。控制获得的数据 患者和早期至中度角膜结构的患者将用于证明WCMT 可以从疾病的早期阶段检测鲍曼层和上皮的改变。 从长远来看，该技术将在基础上产生重要的积极影响 为了发现结构生物标志物，可以在 较早的阶段。