Spatial repellents to reduce the outdoor transmission of malaria

空间驱虫剂可减少疟疾的户外传播

• 批准号: 10542425
• 负责人: Ingrid Ting-Ting Chen
• 金额: $ 12.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542425
• 关键词: Achievement; Affect; Africa; Area; Beds; Bite; Cambodia; Cambodian; Characteristics; Climate; Culicidae; Data; Detergents; Disorientation; Entomology; Evolution; Formulation; Foundations; Frequencies; Future; Health behavior change; High temperature of physical object; Human; Humidity; Insecticides; Interruption; Intervention; Intervention Studies; Latin America; Malaria; Mentorship; Meta-Analysis; Pharmaceutical Preparations; Publishing; Rain; Research; Research Design; Research Personnel; Residual state; Shapes; Source; Southeastern Asia; Surface; Tanzania; Temperature; Testing; Textiles; Thailand; Theory of Change; Time; Training; Volatilization; Water; Weather; design; evidence base; experience; field study; forest; high risk population; malaria transmission; preference; protective efficacy; public health intervention; scale up; skills; small molecule; therapy design; therapy development; transmission process; uptake; vector

ABSTRACT Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthrin-treated hessian fabric strips (TTHFS) offer promise, showing more than six months of mosquito bite deterrence in Tanzanian settings. This project seeks to clarify and advance the evidence base on TTHFS through meta-analysis of Tanzanian studies, semi- field and field testing in Thailand and Cambodia, and user acceptability studies in Cambodia to inform future studies and intervention designs. Aim 1: To determine the relationship between TTHFS characteristics and their protective efficacy over time in Tanzania. I hypothesize that an optimal transfluthrin concentration, fabric strip size, and temperature range for TTHFS can be identified from prior studies in Tanzania, and that impacts on efficacy caused by high temperature and relative humidity can be quantified. Aim 2: To investigate the protective efficacy of TTHFS over time in Thai and Cambodian outdoor conditions. I hypothesize that TTHFS that are efficacious in Tanzania will show similar levels of efficacy in a very different setting against Thai and Cambodian malaria vectors, with similar effects of temperature and humidity on the duration of efficacy. Aim 3: To establish user acceptability and identify modifiable barriers to TTHFS uptake among Cambodian forest rangers and forest goers. I hypothesize that Cambodian forest rangers and forest goers will find TTHFS acceptable due to their ability to reduce mosquito bites, but will be uncomfortable with the product given their limited experience with TTHFS and will have preferences on the size, shape, and design of TTHFS. This study will inform a future interventional study of an optimized TTHFS in Southeast Asia, to be performed subsequent to this K01 study.

抽象的 尽管公认和迫切需要中断室外疟疾的公共卫生干预措施 传输，没有这样的经过验证的干预措施。经陶林处理的黑森织物条（TTHFS） 提供承诺，显示坦桑尼亚环境中六个多月的蚊子叮咬威慑。这个项目 试图通过坦桑尼亚研究的荟萃分析，半澄清和推进TTHF的证据。 泰国和柬埔寨的现场测试以及柬埔寨的用户可接受性研究，以告知未来 研究和干预设计。 目标1：确定TTHFS特征与其保护效果之间的关系 时间在坦桑尼亚。我假设最佳曲林林浓度，织物条尺寸和温度 可以从坦桑尼亚的先前研究中鉴定出TTHF的范围，这影响了高疗效 温度和相对湿度可以量化。 目标2：调查TTHF随着时间的推移在泰国和柬埔寨户外的保护作用 状况。我假设在坦桑尼亚有效的TTHF将在A中显示出相似的功效水平 针对泰国和柬埔寨疟疾载体的设置非常不同，温度和 疗效持续时间的湿度。 目标3：建立用户的可接受性并确定可修改的TTHF摄入障碍 柬埔寨森林护林员和森林群。我假设柬埔寨森林游骑兵和森林爱好者 由于其能够减少蚊子叮咬的能力，会发现TTHF可以接受，但对 鉴于他们在TTHFS经验有限的产品，并且会在大小，形状和设计上具有偏好 tthfs。 这项研究将告知将来对东南亚优化TTHF的介入研究，将进行 在此K01研究之后。