Stress Biology and Psychosocial stressors as mechanisms for Racial Health Disparities in Neural and Clinical Impairments of Multiple Sclerosis

压力生物学和心理社会压力源作为多发性硬化症神经和临床损伤中种族健康差异的机制

• 批准号: 10542320
• 负责人: Shannin Nicole Moody
• 金额: $ 4.78万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-05-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542320
• 关键词: Address; Age; Area; Behavioral; Biological Assay; Biological Markers; Biology; Black American; Black race; Brain; Career Mobility; Characteristics; Clinical; Clinical Research; Cognition; Cognitive; Complement; Data; Data Collection; Demyelinations; Development; Diagnosis; Discrimination; Disease; Disease Progression; Economics; Electroencephalography; Ethnic Origin; Etiology; Funding; Gender; Glucocorticoid Receptor; Goals; Guidelines; Hair; Head Start Program; Health; Hydrocortisone; Impairment; Individual; Individual Differences; Internships; Iowa; Knowledge; Lesion; Life Experience; Light; Longitudinal Studies; MRI Scans; Magnetic Resonance Imaging; Measurable; Measurement; Measures; Mentors; Methodology; Mission; Modeling; Multiple Sclerosis; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Neuraxis; Neuroanatomy; Neurodegenerative Disorders; Neurologic; Neurosciences; Outcome; Outcome Measure; Participant; Patient Self-Report; Persons; Phase; Physiological; Postdoctoral Fellow; Prevalence; Prevention; Psyche structure; Psychosocial Stress; Race; Recording of previous events; Research; Research Project Grants; Research Technics; Research Training; Risk; Science; Severities; Severity of illness; Site; Skin; Socioeconomic Status; Source; Stress; System; Testing; Third ventricle structure; Training; Trauma; United States National Institutes of Health; Weather; Width; Woman; Work; biobehavior; biological adaptation to stress; biopsychosocial; brain tissue; career; cerebral atrophy; clinical predictors; cohort; environmental stressor; experience; health disparity; hypothalamic-pituitary-adrenal axis; indexing; innovation; intersectionality; learning community; longitudinal dataset; matriculation; men; mortality; multiple sclerosis treatment; nervous system disorder; neuroimaging; novel; phenomenological models; post-doctoral training; power analysis; pre-doctoral; psychosocial stressors; racial discrimination; racial health disparity; racism; relating to nervous system; skills; social influence; social stressor; study population; success; theories; young adult

Project Summary/ Abstract The current F99/K00 proposal outlines an integrated pre- and post-doctoral training plan that will result in the applicant being prepared to independently conduct cutting edge interdisciplinary biopsychosocial research. Training goals will augment her solidify her strengths with emerging skills while also attending to professional development and career advancement. The project proposed spans psychosocial stress related outcomes that impact neurological health, specifically as it pertains to MS. To reach this goal, the applicant proposes training in (TG1) Stress Biology which will build on her prior biobehavioral expertise to extend to novel biospecimens and study populations and to complement stress biology with subjective measures of stress and discrimination; (TG2) Neuroscience, especially structural (MRI) measures which complements her prior EEG work; (TG3) Multiple Sclerosis as a debilitating neurological disease with causes brain atrophy but for whom severity of cognitive and physiological clinical outcomes continue to elude the field; and (TG4) Racial Health Disparities which can help shed light on underpinnings for individual differences in clinical MS outcomes through application of theories like Weathering and Intersectionality. The proposal spans two primary sites with an established history of working together which allows the applicant to accomplish innovative work and with an experienced mentor team who work well together through a “community of learning” format and application of Agile Methodology to help the applicant achieve project milestones. The applicant’s long-term goal is to become a transdisciplinary scholar who excels at both stress biology and neuroscience as well as critical race theories and the phenomenology of health disparities. Not only does the applicant seek to increase diversity in the sciences, but the research proposed also will be instrumental for demonstrating the very real, tangible and seemingly intractable impact of racism and discrimination. To achieve these goals, the project proposes three aims as aligned with the aims F99/K00 guidelines. Aim 1b describes the dissertation progress thus far, which includes obtaining approvals for pilot data to establish feasibility at the study site as part of the applicant’s Research Internship, completing training in all study measures including MRI, clinical MS outcomes, hair cortisol assays and scoring self-reported measures, and collecting pilot data for power analysis calculations. Aim 1b outlines work to be completed during the F99, focusing on a conceptual model (and corresponding hypotheses) in which the primary association between brain atrophy and clinical MS outcomes is interrogated in terms of sources of health disparities and then specific moderators are proposed such as hair cortisol and discrimination. Aim 2 describes the postdoctoral research direction as possible next research steps and career moves that will set up the applicant’s career in a way that enhances likelihood of success as a transdisciplinary scholar advancing understanding of how stress gets under the skin to impact health.

项目概要/摘要 目前的 F99/K00 提案概述了一个综合的博士前和博士后培训计划，该计划将导致 申请人准备独立进行前沿的跨学科生物心理社会研究。 培训目标将增强她通过新兴技能巩固自己的优势，同时参加专业课程 该项目提出了与社会压力相关的成果。 影响神经健康，特别是与多发性硬化症相关的疾病。为了实现这一目标，申请人建议进行培训。 （TG1）压力生物学，这将建立在她之前的生物行为专业知识的基础上，扩展到新的生物样本 研究人群并用压力和歧视的主观测量来补充压力生物学； (TG2) 神经科学，特别是结构 (MRI) 测量，补充了她之前的脑电图工作 (TG3)； 多发性硬化症是一种使人衰弱的神经系统疾病，会导致脑萎缩，但对谁来说，其严重程度 认知和生理临床结果继续回避该领域；以及（TG4）种族健康差异 这可以通过以下方式帮助揭示临床多发性硬化症结果个体差异的基础 该提案涵盖了两个主要地点，其中包括风化和交叉性等理论的应用。 建立的合作历史使申请人能够完成创新工作并具有 经验丰富的导师团队通过“学习社区”的形式和应用进行良好的合作 敏捷方法论帮助申请人实现项目里程碑申请人的长期目标是 成为一名在压力生物学、神经科学以及批判种族方面都表现出色的跨学科学者 申请人不仅寻求增加健康差异的理论和现象学。 科学，但所提出的研究也将有助于展示非常真实、有形和 种族主义和歧视看似棘手的影响为了实现这些目标，该项目提出了三个目标。 目标与目标 F99/K00 指南一致，目标 1b 描述了迄今为止的论文进展。 包括获得试点数据的批准，以在研究地点建立可行性，作为申请人的一部分 研究实习，完成所有研究指标的培训，包括 MRI、临床 MS 结果、头发 皮质醇测定和对自我报告的测量进行评分，并收集试点数据以进行功率分析计算。 目标 1b 概述了 F99 期间要完成的工作，重点是概念模型（以及相应的 假设），其中询问脑萎缩与临床多发性硬化症结果之间的主要关联 就健康差异的来源而言，然后提出了具体的调节因素，例如头发皮质醇和 目标 2 将博士后研究方向描述为可能的下一步研究步骤和职业。 将以提高跨学科成功可能性的方式建立申请人的职业生涯的举措 学者们加深了对压力如何渗透到皮肤下影响健康的理解。