Early Adolescents Polysubstance Use Patterns: Longitudinal Changes and Bidirectional Relations with Externalizing Behaviors

青少年早期多物质使用模式：纵向变化和与外化行为的双向关系

基本信息

批准号：
10537578
负责人：
Courtney Dunn
金额：
$ 4.62万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-25 至 2024-06-24
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10537578
关键词：
Address Adolescence Adolescent Adult African American Alcohol consumption Area Behavior Caregivers Cigarette Cities Competence Data Data Analyses Development Equation Etiology Fellowship Frequencies Goals Grant Guide prevention Health Individual Intervention Knowledge Legal Literature Marijuana Mediator of activation protein Mental disorders Mentors Middle School Student Modeling National Institute of Drug Abuse National Research Service Awards Outcome Pattern Physical aggression Poverty Prevention Problem behavior Reporting Research Research Training Risk Risk Factors Role Sampling Statistical Methods Students Subgroup Substance Use Disorder Surveys Testing Time Training Urban Community Violence Writing Youth adolescent alcohol and drug use adolescent substance use adverse outcome career comorbidity early adolescence eighth grade elementary school experience externalizing behavior falls high risk junior high school male multiple drug use peer person centered polysubstance use pre-doctoral protective factors seventh grade sex sixth grade skills social substance use substance using adolescents theories

项目摘要

PROJECT SUMMARY Substance use during early adolescence is associated with a variety of adverse outcomes. Early adolescents often initiate use of more than one substance (i.e., polysubstance use), which increases their risk for negative outcomes, including adult substance use disorders, mental health disorders, and social and legal problems. However, few studies have identified patterns of polysubstance use among early adolescents. There is a critical gap in knowledge of how polysubstance use develops during early adolescence and risk and protective factors for polysubstance use. There is clear evidence that early adolescents’ substance use co-occurs with externalizing behaviors, including physical aggression and delinquent behavior. What is less clear is the extent to which engaging in externalizing behaviors predicts subsequent changes in substance use, or whether substance use predicts changes in externalizing behaviors. Moreover, few studies have tested theoretical mechanisms that may explain these relations. The goal of the proposed study is to address limitations of prior research by identifying subgroups representing patterns of early adolescents’ polysubstance use, establishing their transitions over time, and examining their concurrent and longitudinal bidirectional relations with physical aggression and delinquency. The proposed study will also explore peer and caregiver factors as potential mediators of these relations. These goals align with NIDA’s goal of identifying causes and consequences of substance use, and priority focus (Theme 3) of addressing real-world complexities of substance use, including polydrug use and co-occurring health conditions. The aims will be addressed through analysis of 4 waves of data that were collected every 3 months from a primarily African American sample of 2,755 early adolescents living in urban communities with high rates of poverty and violence. Latent transition analysis and longitudinal cross-lagged structural equation models will be used to examine changes over time. The specific aims are to: 1) Examine longitudinal changes in polysubstance use patterns within and across all three middle school grades, 2) Evaluate concurrent and longitudinal bidirectional relations between physical aggression and delinquency and polysubstance use patterns, and 3) Explore peer delinquency and caregiver knowledge as mediators or predictors of adolescents’ externalizing and substance use behaviors over time. Differences across sex and grade will be examined for each aim. The findings will inform prevention efforts by refining our understanding of risk for early polysubstance use, potentially highlighting optimal intervention periods, and identifying possible intervention targets. Moreover, the research and training outlined in this NRSA F31 pre- doctoral fellowship application will equip the applicant with skills and mentoring needed to pursue an independent research career, including knowledge of factors that impact adolescents’ substance use, competences in advanced longitudinal statistical methods, and professional skills related to scientific writing and dissemination.

项目摘要青春期早期的物质使用与各种不良后果通常会启动多种物质（即polysubstance使用），这会增加其负面风险结果，包含成人药物使用障碍，心理健康障碍以及社会和法律问题。但是，很少有研究确定早期青少年中多义能使用的模式。在青春期早期和风险和保护者的知识中，知识的限制差距使用多物质的因素，有明确的证据表明外在的行为，包括身体侵略和犯罪行为。从事外部化行为可以预测物质使用的后续变化，或者是否物质的使用预测了外在行为的变化。可能解释这些关系的机制。通过确定抑制早期青少年使用多物质使用的亚组的研究，建立随着时间的流逝，他们的过渡，并检查他们的并发和纵向双向关系侵略性和违法性。关系的调解人。物质使用和优先重点（主题3），以解决现实世界中使用物质的复杂性，包括通过对4波的分析，将使用和同时使用的健康状况每3个月收集一次的数据，主要是2,755名早期青少年的非裔美国人样本在城市社区中生活，有贫困和暴力。交叉滞后的结构方程模型遗嘱将用于检查特定目的。 1）检查在所有三个中学内和整个中学中使用pattans的纵向变化等级，2）评估身体侵略与纵向双向关系和纵向双向关系拖欠和多物种使用模式，以及3）探索同伴犯罪和照料者知识随着时间的流逝，青少年外在化和物质使用行为的预测因素每个目标都会通过完善我们的发现。了解早期使用多物结构的风险，潜在地强调最佳干预期，ANDDS 确定可能的国际目标。博士奖学金申请申请申请人提供钱包所需的技能和指导独立的研究职业，包括了解因素因素使用物质使用因素的知识，高级纵向统计方法的能力以及与科学写作有关的专业技能和传播。