Particulate air pollution and effects on cardiovascular health in American Indian communities

美洲印第安人社区的颗粒物空气污染及其对心血管健康的影响

• 批准号: 10537326
• 负责人: Mengyuan Li
• 金额: $ 3.37万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10537326
• 关键词: Address; Air; Air Pollutants; Air Pollution; American; American Indians; Ammonium; Arizona; Automobile Driving; Blood Glucose; Carbon Black; Cardiovascular Diseases; Cause of Death; Cohort Studies; Communities; Coronary heart disease; County; Data; Diabetes Mellitus; Diagnosis; Disease; Disease Outcome; Dust; Environmental Health; Event; Exposure to; Face; Fasting; Funding; Future; Great Plains; Health; Heart; Heart Diseases; Heart Rate; Heart failure; High Density Lipoprotein Cholesterol; High Prevalence; Household; Hypertension; Hypertriglyceridemia; Incidence; Income; Intervention; Longitudinal Studies; Measures; Metabolic; Metabolic syndrome; Modeling; Modification; Monitor; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Nitrates; Non-Insulin-Dependent Diabetes Mellitus; North Dakota; Obesity; Oklahoma; Outcome; Participant; Particulate; Particulate Matter; Persons; Population; Population Density; Populations at Risk; Prevalence; Prevention; Race; Regulation; Reporting; Research; Rest; Risk; Risk Factors; Role; Running; Rural; South Dakota; Stroke; Sulfate; Time; United States; United States Environmental Protection Agency; Update; Work; ambient air pollution; base; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cohort; diabetes risk; disorder risk; environmental health disparity; epidemiology study; ethnic minority; evidence base; experience; fine particles; high risk; improved; mortality; racial minority; response; rural Americans; rural area; social disadvantage; trend; tribal community; waist circumference

PROJECT SUMMARY/ABSTRACT Air pollution is a key environmental determinant of cardiovascular health, yet most studies have been conducted in predominantly white, non-rural populations. Evidence elucidating this exposure-response relation- ship is limited for rural, American Indian tribal communities primarily located in regions with air pollution levels below the current National Ambient Air Quality Standards (NAAQS). To address this research gap, we intend to compare ambient fine particulate matter (PM2.5) concentrations in American Indian communities to the rest of the United States (US) and estimate the associations between PM2.5 and incident cardiovascular disease (CVD) in tribal communities located in the Northern Great Plains (North/South Dakota), Southern Great Plains (Okla- homa), and American Southwest (Arizona), leveraging data from the NHLBI-funded Strong Heart Study (SHS) cohort. We will: 1) estimate concentrations of the six PM2.5 constituents contributing the most to total PM2.5 mass (sulfate, nitrate, ammonium, organic matter, black carbon, and dust) over time in largely AI-populated counties compared to other US counties using existing well-validated, highly spatially resolved satellite-based models; 2) evaluate the association of long-term exposure to a) total PM2.5 and b) six PM2.5 constituents with incident CVD, measuring the effect of PM2.5 exposure on any incident CVD and specific CVD outcomes separately (coronary heart disease (CHD), heart failure, stroke); 3) assess effect modification of the association between total PM2.5 exposure on incident CVD by diabetes status in the SHS and conduct an exploratory analysis of effect modification by metabolic syndrome (MetS), diagnosed in SHS participants who meet at least three of five con- ditions: (1) high waist circumference, (2) high triglyceride level, (3) low HDL cholesterol, (4) high blood pressure, and (5) high fasting blood glucose. Estimating ambient PM2.5 trends in AI communities across the contiguous US and quantifying PM2.5 ex- posure effects on incident CVD risk in the SHS will help advance understanding of environmental health burdens faced in socially disadvantaged communities. Our findings can be used to promote evidence-based prevention and intervention at various scales, from local to national. This work can help inform community-based interven- tions within AI communities to decrease PM2.5 levels and improve cardiovascular health outcomes and prioriti- zation of equitable representation in future iterations of NAAQS.

项目摘要/摘要 空气污染是心血管健康的关键环境决定因素，但大多数研究是 以白色的非农村人群为主。阐明这种暴露响应关系的证据 船只限制在主要位于空气污染水平的地区的农村，美洲印第安部落社区 低于当前国家环境空气质量标准（NAAQS）。为了解决这一研究差距，我们打算 比较美洲印第安人社区的环境细颗粒物（PM2.5）浓度与其余部分 美国（美国）并估算PM2.5与入射心血管疾病（CVD）之间的关联 在位于大平原北部/南达科他州北部的部落社区中，大平原南部（俄克拉荷马州） HOMA）和美国西南部（亚利桑那州）利用NHLBI资助的强大心脏研究（SHS）的数据 队列。我们将：1）估计六个PM2.5成分的浓度，对总PM2.5质量造成了最大的贡献 （硫酸盐，硝酸盐，铵，有机物，黑碳和灰尘）随着时间的流逝 与其他美国县相比，使用现有的经过良好验证的，高空间解决的基于卫星的模型； 2） 评估长期接触a）a）总PM2.5和b）六个PM2.5成分与入射CVD的成分， 分别测量PM2.5暴露对任何事件CVD和特定CVD结果的影响（冠状动脉 心脏病（CHD），心力衰竭，中风）； 3）评估效应的效果修改总计之间的关联 PM2.5 SHS中糖尿病状态的事件CVD暴露并进行探索性分析 通过代谢综合征（METS）进行修改，在SHS参与者中诊断出，他们至少遇到了五个参与者中的三个 病态：（1）高腰围，（2）高甘油三酸酯水平，（3）低HDL胆固醇，（4）高血压， （5）高空血糖。 估算整个连续美国的AI社区的环境PM2.5趋势，并量化PM2.5 SHS中对事件CVD风险的姿势影响将有助于提高对环境健康负担的了解 面对社会不利的社区。我们的发现可用于促进基于证据的预防 以及从本地到国家的各种规模的干预。这项工作可以帮助以社区为基础的中间 - 人工智能社区内的tips以降低PM2.5水平并改善心血管健康结果和优先级 NAAQ的未来迭代中公平代表的Zation。