Effect of protein supplementation during weight loss on older adult bone health

减肥期间补充蛋白质对老年人骨骼健康的影响

• 批准号: 10534765
• 负责人: Ashley Weaver
• 金额: $ 13.3万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534765
• 关键词: 3-Dimensional; Adipocytes; Adipose tissue; Affect; Aging; American; Ancillary Study; Animal Model; Applications Grants; Assessment tool; Attenuated; Award; Biomedical Engineering; Body Composition; Body Weight decreased; Body mass index; Bone Density; Bone Marrow; Bone structure; Carbohydrates; Classification; Clinical; Clinical Research; Clinical Trials; Complement; Conduct Clinical Trials; Consumption; Data; Development; Diagnostic; Diet; Dietary Proteins; Dual-Energy X-Ray Absorptiometry; Elderly; Elements; Engineering; Exercise; Femur; Fracture; Geriatrics; Gerontology; Hip region structure; Image; Infrastructure; Intervention; Knowledge; Lead; Measurement; Measures; Medical Imaging; Mentored Research Scientist Development Award; Mentors; Modeling; Musculoskeletal; Nutritional; Nutritional Science; Obesity; Osteoporosis; Osteoporosis prevention; Outcome; Overweight; Participant; Persons; Pharmacotherapy; Phase; Phenotype; Physical Function; Population; Protein-Restricted Diet; Proteins; Radiology Specialty; Randomized; Recommendation; Recommended Dietary Allowance; Recording of previous events; Regulation; Research; Research Personnel; Resources; Risk; Scanning; Supplementation; Techniques; Testing; Thick; Thinness; Training; Trauma; United States National Institutes of Health; Vertebral column; Weight; Woman; X-Ray Computed Tomography; adult obesity; bone; bone health; bone loss; bone mass; bone metabolism; bone preservation; bone quality; bone strength; career; design; experience; follow-up; forest; fracture risk; high risk; improved; innovation; medical schools; men; multidisciplinary; nutrition; osteoporosis with pathological fracture; osteoprotective; prevent; prognostic tool; protein intake; research and development; risk prediction; spine bone structure; tool; translational study; weight maintenance

Project Summary. Dr. Weaver seeks this K25 mentored training award to expand her bioengineering research background in medical imaging and finite element modeling of trauma towards pursuit of an independent research career focused on reducing osteoporosis and fracture in older adults. Weight loss poses an increased risk of bone loss and fracture in older adults. The proposed research will test the overall hypothesis that higher dietary protein intake during and following weight loss will attenuate bone loss in older adults with obesity. Guided by an accomplished multidisciplinary mentoring team with expertise in aging, clinical trials, bone metabolism, nutrition, and radiology, the PI will: (1) Develop knowledge of gerontology and geriatric medicine, (2) Acquire training in the design and execution of clinical trials, 3) Obtain in-depth knowledge on bone metabolism and structure, including the influence of nutrition and weight loss, and 4) Develop expertise in dual-energy computed tomography (CT) acquisition and post-processing to measure volumetric bone mineral density, cortical thickness, and bone marrow adipose tissue. Dr. Weaver's training and research will take place at Wake Forest School of Medicine which has a strong history of clinical research in aging and an exceptional radiology infrastructure. The partnership with her co-mentor at Rutgers within the Department of Nutritional Sciences will provide additional resources and expertise related to the nutritional regulation of bone metabolism. The proposed ancillary study to the ongoing clinical trial, UPLIFT: Utilizing Protein During Weight Loss to Impact Physical Function, will examine bone health over 6 months of active weight loss, followed by 12 months of weight maintenance. Musculoskeletal phenotypes will be compared in older adults with obesity randomized to either: (1) a lower protein diet for weight loss and follow-up, (2) a higher protein diet for weight loss only, or (3) a higher protein diet for weight loss and follow-up. The ancillary study expands the UPLIFT trial by adding dual-energy CT scans of the lumbar spine and proximal femur at baseline, 6 months, and 18 months to compare the influence of a higher versus lower protein intake on: vertebral and femoral trabecular volumetric bone mineral density and cortical thickness (Primary Aim), bone marrow adiposity which may alter the trabecular matrix and affect bone strength (Secondary Aim 1), and bone strength and fracture risk predicted with subject-specific finite element modeling (Secondary Aim 2). The study will test if a higher protein diet improves bone outcomes during active weight loss (evaluated at 6 months), and if maintaining higher protein intake during weight maintenance further preserves bone (evaluated at 18 months). The proposed training and research plan will launch Dr. Weaver's career as an independent investigator focused on applying bioengineering techniques to: 1) develop translational tools for fracture prediction, and 2) assess osteoprotective interventions in clinical trials—ultimately leading to improved diagnostics, prognostic tools, clinical recommendations, and therapies for preventing osteoporosis and fracture in older adults.

项目摘要。 Weaver博士寻求此K25修订培训奖，以扩大她的生物工程研究 医学成像和有限元模型的背景创伤追求独立的背景 研究职业的重点是减少老年人的骨质疏松和骨折。减肥会增加 老年人骨质流失和骨折的风险。拟议的研究将检验总体假设，即较高 减肥期间和之后的饮食蛋白质摄入将减轻肥胖老年人的骨质损失。指导 由成就良好的多学科指导团队，在衰老，临床试验，骨骼代谢方面具有专业知识， 营养和放射学，PI将：（1）发展老年医学和老年医学知识，（2）获取 在临床试验的设计和执行方面的培训，3）获得有关骨代谢和的深入知识 结构，包括营养和体重减轻的影响，以及4）在计算的双能中发展专业知识 层析成像（CT）采集和后处理，以测量体积骨矿物质密度，皮质厚度， 和骨髓脂肪组织。 Weaver博士的培训和研究将在Wake Forest School的 医学在衰老和卓越的放射学基础设施方面具有悠久的临床研究史。这 与她在营养科学系的罗特（Rutgers）的联合学伙伴关系将提供其他 与骨代谢的营养调节有关的资源和专业知识。拟议的辅助研究 进行正在进行的临床试验，振奋：在体重减轻期间利用蛋白质来影响身体机能，将 检查骨骼健康在6个月内的积极体重减轻，然后进行12个月的体重维持。 将肥胖的老年人随机分配给肌肉骨骼表型：（1）较低 蛋白质饮食减肥和随访，（2）仅用于减肥的较高蛋白质饮食，或（3）较高的蛋白质饮食 减肥和随访。辅助研究通过添加双能CT扫描扩展了提升试验 基线时腰椎和近端股骨，6个月和18个月，以比较较高的影响 与较低的蛋白质摄入量：椎骨和股骨小梁骨矿物质密度和皮质 厚度（主要目的），骨髓肥胖，可能会改变小梁基质并影响骨骼强度 （次要目标1），以及主体特异性有限元建模预测的骨骼强度和断裂风险 （次要目标2）。该研究将测试较高的蛋白质饮食在主动减肥过程中是否改善骨骼结局 （在6个月时进行评估），如果在体重维持期间保持较高的蛋白质摄入量，请进一步保存 骨（在18个月时评估）。拟议的培训和研究计划将启动Weaver博士的职业 专注于将生物工程技术应用于以下方面的独立研究人员：1）开发转化工具 断裂预测和2）评估临床试验中的骨保护干预措施 - 最终导致改善 诊断，预后工具，临床建议和预防骨质疏松症的疗法 在老年人中。

项目成果

Lumbar Spine Response of Computational Finite Element Models in Multidirectional Spaceflight Landing Conditions.

多向航天着陆条件下计算有限元模型的腰椎响应。

• DOI: 10.1115/1.4045401
• 发表时间: 2020
• 期刊: Journal of biomechanical engineering
• 作者: Ye,Xin;Jones,DerekA;Gaewsky,JamesP;Koya,Bharath;McNamara,KyleP;Saffarzadeh,Mona;Putnam,JacobB;Somers,JeffreyT;Gayzik,FScott;Stitzel,JoelD;Weaver,AshleyA
• 通讯作者: Weaver,AshleyA

Computed tomography assessment of pelvic bone density: Associations with age and pelvic fracture in motor vehicle crashes.

骨盆骨密度的计算机断层扫描评估：与年龄和机动车碰撞中骨盆骨折的关联。

• DOI: 10.1016/j.aap.2023.107291
• 发表时间: 2023
• 期刊: Accident; analysis and prevention
• 作者: Weaver,AshleyA;Ronning,IsaacN;Armstrong,William;Miller,AnnaN;Kiani,Bahram;ShaynMartin,R;Beavers,KristenM;Stitzel,JoelD
• 通讯作者: Stitzel,JoelD

Comparing rib cortical thickness measurements from computed tomography (CT) and Micro-CT.

比较计算机断层扫描 (CT) 和 Micro-CT 的肋骨皮质厚度测量结果。

• DOI: 10.1016/j.compbiomed.2019.103330
• 发表时间: 2019
• 期刊: Computers in biology and medicine
• 影响因子: 7.7
• 作者: Hostetler,ZacharyS;Stitzel,JoelD;Weaver,AshleyA
• 通讯作者: Weaver,AshleyA

Comparison of morphing techniques to develop subject-specific finite element models of vertebrae.

开发特定主题椎骨有限元模型的变形技术的比较。

• DOI: 10.1080/10255842.2022.2113994
• 发表时间: 2023
• 期刊: Computer methods in biomechanics and biomedical engineering
• 影响因子: 1.6
• 作者: Rubenstein,RafaelI;Lalwala,Mitesh;Devane,Karan;Koya,Bharath;Kiani,Bahram;Weaver,AshleyA
• 通讯作者: Weaver,AshleyA

Characterization of subcutaneous pelvic adipose tissue morphology and composition at the plane of the ASIS: A retrospective study of living subjects.

ASIS 平面皮下盆腔脂肪组织形态和成分的表征：对活体受试者的回顾性研究。

• DOI: 10.1080/15389588.2022.2133887
• 发表时间: 2022
• 期刊: Traffic injury prevention
• 影响因子: 2
• 作者: Moore,AustinM;Efobi,SamanthaM;Aira,Jazmine;Weaver,AshleyA;Lenchik,Leon;Hsu,Fang-Chi;Gayzik,FScott
• 通讯作者: Gayzik,FScott