XtremeCT II high-resolution peripheral quantitative computed tomography (HR-pQCT) scanner

XtremeCT II 高分辨率外周定量计算机断层扫描 (HR-pQCT) 扫描仪

• 批准号: 10420213
• 负责人: Ashley Weaver
• 金额: $ 43.75万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2024-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10420213
• 关键词: Address; Adult; Advisory Committees; Aging; Applications Grants; Architecture; Biological; Bone Density; Chronic Kidney Failure; Computed Tomography Scanners; Computer Models; Development; Diabetes Mellitus; Diet; Elderly; Exercise; Fostering; Fracture; Funding; Genomics; Health; Image Analysis; Imaging Device; Incidence; Injury; Institutes; Interdisciplinary Study; Intervention; Investigation; Leadership; Life Style; Longevity; Minor; Musculoskeletal; Outcome; Peripheral; Population Heterogeneity; Proteins; Radiation; Rehabilitation therapy; Research; Resolution; Role; Skeletal Muscle; Skeleton; System; Techniques; Technology; United States National Institutes of Health; Vehicle crash; Weight; Weight maintenance regimen; Weight-Bearing state; X-Ray Computed Tomography; age related; base; biomedical imaging; bone; bone health; bone imaging; bone loss; bone strength; comorbidity; cost effectiveness; ethnic diversity; forest; fracture risk; imaging modality; imaging program; insight; instrument; medical schools; novel; skeletal; success; treatment strategy

Project Abstract In this Shared Instrument Grant application, we are requesting funds to acquire an XtremeCT II High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) scanner. HR-pQCT is a non-invasive, low radiation approach for assessing compartment-specific volumetric bone mineral density (vBMD) and bone microarchitecture in the peripheral skeleton to estimate bone strength and fracture risk. Integration of this state- of-the-art skeletal imaging modality into the repertoire of biomedical imaging tools available at Wake Forest School of Medicine (WFSM) advances the initiatives of 18 NIH-funded centers, institutes, and departments; and bolsters collaborative efforts with several of our regional partners. Specifically, acquisition of HR-pQCT technology will allow the proposed major and minor user groups to: 1) better understand the effects of lifestyle- based strategies — such as weight-bearing exercise and a high protein diet — on skeletal health among older adults losing weight; 2) expand the investigation of the role of age-related biological changes in skeletal muscle on the decline in mobility to include interactions with bone; 3) demonstrate the potential of advanced image analyses techniques to augment histostructural outcomes; 4) provide insight into the genomic architecture of bone health to aid in the development of novel treatment strategies to mitigate bone loss in aging; 5) better capture musculoskeletal comorbidities among motor vehicle crash occupants, and understand their influence on injury incidence and rehabilitation success; 6) address important gaps on the effects of weight management interventions on the growing skeleton; 7) evaluate whether bone microarchitecture varies across ethnically diverse populations; 8) augment computational modeling strategies assessing change in bone health across the lifespan to include bone microarchitecture and strength; and 9) determine the timing of and extent to which intracortical bone loss occurs among adults with diabetes mellitus and chronic kidney disease. To promote cost effectiveness, encourage optimal sharing, and foster multidisciplinary collaborations, the HR-pQCT will be housed in the Translational Imaging Program Core at WFSM, where it will be overseen by qualified leadership, operational, and advisory committees in accordance with well-organized and self-sustaining administrative and financial plans. Ultimately, the addition of a HR-pQCT system will enable WFSM to engage in more multidisciplinary collaborations, compete more successfully for external research funding, and remain at the forefront of musculoskeletal research endeavors.

项目摘要 在此共享的工具赠款申请中，我们要求资金获得Xtremect II高 分辨率外围定量计算机断层扫描（HR-PQCT）扫描仪。 HR-PQCT是无创的， 评估室特异性体积骨矿物质密度（VBMD）和骨的低辐射方法 外围骨骼中的微结构，以估计骨骼强度和断裂风险。该州的整合 在Wake Forest可用的生物医学成像工具曲目中的Art骨骼成像模态 医学院（WFSM）推进了18个NIH资助的中心，研究所和部门的倡议；和 Bolsters与我们的几个区域合作伙伴的合作努力。具体而言，获得HR-PQCT 技术将使拟议的主要和次要用户群体：1）更好地了解生活方式的影响 - 老年人的骨骼健康的基于基于体重运动和高蛋白质饮食等策略 成人减肥； 2）扩大与年龄相关的生物学变化在骨骼肌肉中的作用的投资 关于包括与骨骼相互作用的流动性下降； 3）演示高级图像的潜力 分析技术以增强历史结构结果； 4）提供有关基因组结构的见解 骨骼健康有助于制定新的治疗策略，以减轻衰老的骨质流失； 5）更好 捕获汽车撞车乘员中的肌肉骨骼合并症，并了解其对 伤害事件和康复成功； 6）解决体重管理影响的重要差距 对成长骨骼的干预措施； 7）评估骨微体系结构是否在种族上有所不同 多样化的人口； 8）增强评估骨骼健康变化的计算建模策略 寿命包括骨微结构和力量； 9）确定在哪个时间和程度的时间和程度 糖尿病和慢性肾脏疾病的成年人发生了皮质内骨质流失。促进成本 有效性，鼓励最佳共享和培养多学科合作，HR-PQCT将是 位于WFSM的翻译成像计划核心中，该核心将由合格领导 根据组织良好且自我维持的行政和咨询委员会的运营和咨询委员会 财务计划。最终，增加HR-PQCT系统将使WFSM参与更多 多学科合作，更成功地争夺外部研究资金，并留在 肌肉骨骼研究的最前沿。