Helium Recycling for UIC Nuclear Magnetic Resonance

UIC 核磁共振氦气回收

• 批准号: 10533681
• 负责人: Stephanie M Cologna
• 金额: $ 35.09万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533681
• 关键词: Address; Applied Research; Atmosphere; Biomedical Research; Biophysics; Chicago; Communities; Core Facility; Development; Electron Microscopy; Engineering; Ensure; Environmental Impact; Funding; Gases; Geometry; Goals; Health; Helium; Illinois; Institution; Laboratories; Liquid substance; Maintenance; Manuals; Mass Spectrum Analysis; Modernization; Monitor; Natural Resources; Nuclear Magnetic Resonance; Plumbing; Proteins; Radioactive; Recovery; Recycling; Research Personnel; Research Support; Resources; Site; Structure; System; Techniques; Universities; Vendor; Work; X-Ray Crystallography; base; cold temperature; cost; cost effectiveness; cryogenics; design; drug discovery; instrument; instrumentation; operation; pressure; quantum; response; small molecule; solid state; structural biology; time use

Project summary Nuclear magnetic resonance (NMR) is a critical technique for characterization of small molecules such as proteins, including their structure, dynamics monitoring and quantitative analysis, among others. For proper operation of NMR instrumentation, cryogenic liquids such as helium are necessary to maintain low temperatures required for operation. Helium is a limited natural resource and much of the cryogenic liquid used for instruments such as NMR is released to the atmosphere during both routine operation and occasional magnet fills. To address this issue, commercial vendors have developed helium gas capture and recycling systems to be able to address the boil off loss. At the University of Illinois Chicago (UIC), our shared NMR instrument core, located in the Center for Structural Biology, houses three NMR spectrometers with an additional instrument planned for installation in the coming months. Thus, this facility demands substantial liquid helium, which is both costly and uses a depleting natural resource. In response to this funding announcement, we are proposing to prepare the site and install a helium recycling unit that has multi- instrument capabilities in the Center for Structural Biology. The addition of this new system will streamline our operations, modernize our facility and enable an increased user base for this shared facility.

项目摘要 核磁共振（NMR）是表征小分子（例如）的关键技术 蛋白质，包括其结构，动力学监测和定量分析等。适当 NMR仪器的运行，诸如氦气之类的低温液体以保持低 操作所需的温度。氦是一种有限的自然资源，大量的低温液体使用 对于诸如NMR之类的仪器，在常规操作和偶尔的情况下都会释放到大气 磁铁填充。为了解决这个问题，商业供应商开发了氦气捕获和回收 能够解决沸腾损失的系统。在伊利诺伊大学芝加哥大学（UIC），我们的共享NMR 仪器核心位于结构生物学中心，载有三个NMR光谱仪 计划在未来几个月内安装的其他仪器。因此，该设施需要大量 液体氦气既昂贵又使用耗尽的自然资源。回应这笔资金 宣布，我们建议准备站点并安装一个具有多种多样的氦气回收单元 结构生物学中心的仪器能力。此新系统的添加将简化我们的 操作，使我们的设施现代化，并为此共享设施提供增加的用户群。