SCISIPBIO: Understanding and Assembling Dream Teams to Conduct Clinical and Translational Science

SCISIPBIO：了解和组建开展临床和转化科学的梦之队

• 批准号: 10529291
• 负责人: Alina Ionica Lungeanu
• 金额: --
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10529291
• 关键词: Applications Grants; Automobile Driving; Biomedical Research; Clinical; Clinical Sciences; Collaborations; Development; Discipline; Dreams; Education; Effectiveness; Funding; Funding Agency; Future; Goals; Grant; Healthcare; Individual; Institution; Investments; Ontology; Pattern; Performance; Pilot Projects; Policy Maker; Procedures; Process; Productivity; Recommendation; Reporting; Research; Research Personnel; Research Project Grants; Science; Source; System; Time; Translational Research; Underrepresented Minority; United States National Institutes of Health; Vision; biomedical scientist; career; cost; demographics; design; human capital; improved; insight; novel; programs; success; tool

We hail individual geniuses, but success in science comes through collaboration (Farrar, 2017)." Biomedical breakthroughs come from collaboration that crosses boundaries. Boundaries created by disciplines, organizations, cultures, professions, and demographics. While cross-boundary collaboration in team science has demonstrated benefits, research also suggests they are unlikely to form, and when they do, are prone to coordination costs (Cooke & Hilton, 2015). This research project advances the Science of Team Science by "understanding" and "assembling" cross-boundary teams to conduct clinical and translational science. This research enables scholars and policymakers to design and assess "dream teams." Toward the aim of understanding, we conduct archival studies of NIH's Clinical & Translational Science Pilot Grant programs at two institutions to reveal the team assembly factors that drive formation and success. Toward the aim of assembling, we leverage a newly developed team recommender system. The fundamental goal is to generate recommendations to shift the composition of teams submitting Pilot Grant applications in particular and cross-boundary scientific teams in general. Insights from this project come at a critical point in time, when cross-boundary science is essential for biomedical research. Toward that aim, this project has two key sources of intellectual merit. First, the research advances the science of team science (Cooke & Hilton, 2015), answering calls to better understand the multilevel determinants of science team success. How are they forming and which ones are performing? Following teams from formation to maturity provide a holistic understanding of the factors driving team formation and performance. Knowing how to better assemble scientific teams has the potential to improve the career productivity of a major source of human capital, and to hasten breakthroughs in biomedical research. Furthermore, not all cross-boundary teams are successful. Previous research provides competing advice for those assembling teams. On the one hand, cross- boundary teams are most likely to produce novel insights (Stvilia et al., 2011; Uzzi et al., 2013), but they are also most likely to suffer process losses from their coordination costs (Cummings & Kiesler, 2007; Cummings et al., 2013). This large scale analysis will allow us to discover patterns that differentiate the kinds of cross-boundary teams who are ultimately successful from those who are not. The second source of intellectual merit is the development of a team recommender system for biomedical scientists to use to assemble cross-boundary teams for Pilot Projects. The Dream Team Builder was specifically mentioned in the NAS report as it builds on NIH-funded VIVO's ontology. We extend this tool to provide team recommendations, and study their effects on team assembly and future performance.

我们赞美个人天才，但科学的成功是通过合作而来的 （Farrar，2017年）。“生物医学突破来自跨越边界的合作。 学科，组织，文化，专业和人口统计。在团队中跨界合作 科学已经证明了好处，研究还表明，它们不太可能形成，当它们这样做时，很容易出现 协调费用（Cooke＆Hilton，2015年）。该研究项目通过 “理解”和“组装”跨边界团队进行临床和转化科学。这项研究 使学者和决策者能够设计和评估“梦想团队”。为了理解的目的，我们 对NIH的临床和转化科学试验赠款计划进行档案研究，以揭示 团队组装因素推动形成和成功。为了组装，我们利用新的 开发的团队推荐系统。基本目标是产生建议以转移构图 一般来说，提交试点赠款申请的团队，总体上是跨界科学团队。 这个项目的见解是在关键的时间点，当时跨边界科学对于生物医学至关重要 研究。为了实现这一目标，该项目具有两个关键的知识分子来源。首先，研究推进了 团队科学科学（Cooke＆Hilton，2015年），回答以更好地了解多层次决定因素的呼吁 科学团队的成功。它们如何形成以及哪些表现？遵循从组到的团队 成熟度提供了对驱动团队形成和绩效的因素的整体理解。知道如何 更好的组装科学团队有可能提高人类主要来源的职业生产力 资本，并加快生物医学研究的突破。此外，并非所有的跨界团队都是 成功的。先前的研究为那些组装团队提供了竞争建议。一方面，交叉 边界团队最有可能产生新颖的见解（Stvilia等，2011; Uzzi等，2013），但它们也是 最有可能因其协调成本而遭受过程损失（Cummings＆Kiesler，2007； Cummings等，。 2013）。这种大规模的分析将使我们能够发现区分跨界团队的模式 最终从没有的人那里取得了成功。智力优点的第二个来源是发展 用于生物医学科学家的团队推荐系统，用于组装试点项目的跨界团队。这 NAS报告中特别提到了Dream Team Builder，因为它建立在NIH资助的Vivo本体论的基础上。我们 扩展此工具以提供团队建议，并研究其对团队组装和未来绩效的影响。