TBEL Administrative Core

TBEL 行政核心

基本信息

批准号：
10518914
负责人：
ANGELO Michael DE MARZO
金额：
$ 16.66万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10518914
关键词：
Address Atlases Basic Science Collaborations Communication Communities DNA Methylation Data Analyses Data Collection Development Discipline Electronic Mail Ensure Evaluation Evolution Fostering Funding GSTP1 gene Genomics Grant Human Resources Individual Indolent Inflammation Inflammatory Infrastructure Institution Joints Knowledge Leadership Lesion Logistics Malignant Neoplasms Malignant neoplasm of prostate Mentors Mission Modality Molecular and Cellular Biology Neoplasms Peer Review Postdoctoral Fellow Procedures Progress Reports Prostate Prostatic Publications Research Research Activity Research Personnel Research Project Grants Role Site Visit Students Summary Reports Supervision Teleconferences Telephone Work anticancer research carcinogenesis data management diverse data graduate student interdisciplinary approach meetings molecular pathology mouse model pre-clinical programs support network synergism transcriptome sequencing translational approach tumor microenvironment virtual working group

项目摘要

Project Summary/Abstract: The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core combine with synergy beyond their individual parts, to contribute to the TBEL Program creating strength beyond the individual Centers, to integrate with the NCI and the cancer research community. The Administrative Core provides the infrastructure essential for this mission. The Core will supervise a multi-component research program encompassing two basic science and one translational projects, and utilizing diverse data collection and analysis modalities. To foster synergy, the Core will be the primary contact for internal activities including logistical and organizational activities, scientific and administrative activities, and collaborative project solicitation, review, funding, and evaluation. To embed our proposed Center within the TBEL Program and the broader cancer research community, this Core will also be the primary contact for external interactions with the NCI, other TBEL Centers, the Coordinating and Data Management Center (CDMC), and external cancer researchers. The Core Leaders, Drs. De Marzo and Yegnasubramanian, have been active collaborators for 19 years, have joint funding on the NCI SPORE grant as well as the NCI MCL grant for the past 6 years and are co-authors on 50 peer-reviewed primary publications and 16 review articles. Drs. De Marzo and Yegnasubramanian are also embedded in internal and external research networks that support their roles. In addition, they have co-mentored several graduate students and post-doctoral fellows, often serving on their fellow graduate student's thesis committees. They have worked together extensively on the molecular pathology and genomics of prostate cancer over the last 10 years, including leading all the RNAseq and whole genomic sequencing efforts for JHU the NCI MCL-U01 projects, including the pre-clinical atlas pilot. Also, together they have worked extensively on the molecular and cellular biology of prostate precursor lesions , together finding partial DNA methylation of GSTP1 in high grade PIN lesions and PIA; a finding directly relevant to the current proposal. Finally, they have worked together extensively, with Dr. Bieberich, on the molecular pathology and genomics of mouse models of prostatic inflammation driven neoplasia and of aggressive versus indolent prostate cancer, and with Dr. Pienta in all administrative aspects and tumor microenvironment studies related to the NCI MCL-U01 Program.

项目摘要/摘要：行政核心的使命是确保各个研究项目和研究核心结合各个部分以外的协同作用，为 TBEL 计划做出贡献，创造超越各个部分的力量各个中心，与 NCI 和癌症研究界整合。行政核心提供完成这一任务所必需的基础设施。核心将监督一个多组成部分的研究计划涵盖两项基础科学和一项转化项目，并利用多种数据收集和分析方式。为了促进协同作用，核心将成为内部活动的主要联系人，包括后勤和组织活动、科学和行政活动以及协作项目征集、审查、资助和评估。将我们提议的中心嵌入 TBEL 计划和更广泛的癌症研究中社区，该核心也将成为与 NCI、其他 TBEL 中心进行外部互动的主要联系人，协调和数据管理中心 (CDMC) 以及外部癌症研究人员。核心领导，博士。 De Marzo 和 Yegnasubramanian 19 年来一直是积极的合作者，共同资助 NCI 过去 6 年获得 SPORE 资助以及 NCI MCL 资助，并且是 50 项经过同行评审的初级研究的合著者出版物和 16 篇评论文章。博士。 De Marzo 和 Yegnasubramanian 也融入了内部和支持其角色的外部研究网络。此外，他们还共同指导了多名研究生和博士后研究员，经常在研究生同学的论文委员会任职。他们已经工作了在过去 10 年里，我们广泛研究了前列腺癌的分子病理学和基因组学，包括领导 JHU 和 NCI MCL-U01 项目的所有 RNAseq 和全基因组测序工作，包括临床前阿特拉斯试点。此外，他们还一起在前列腺的分子和细胞生物学方面进行了广泛的研究前驱病变，在高级 PIN 病变和 PIA 中共同发现 GSTP1 的部分 DNA 甲基化；一个发现与当前提案直接相关。最后，他们与 Bieberich 博士在以下方面进行了广泛的合作：前列腺炎症驱动的肿瘤和侵袭性小鼠模型的分子病理学和基因组学与惰性前列腺癌的比较，以及 Pienta 博士在所有管理方面和肿瘤微环境方面的研究与 NCI MCL-U01 计划相关的研究。