Admin-Core-001

管理核心-001

• 批准号: 10933141
• 负责人: ANGELO Michael DE MARZO
• 金额: $ 8.22万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10933141
• 关键词: Address; Atlases; Automobile Driving; Basic Science; Collaborations; Communication; Communities; DNA Methylation; Data Analyses; Data Collection; Data Coordinating Center; Discipline; Electronic Mail; Evaluation; Evolution; Fibroblasts; Fostering; Funding; GSTP1 gene; Genomics; Grant; Human Resources; Individual; Indolent; Inflammation; Infrastructure; Institution; Joints; Knowledge; Leadership; Lesion; Malignant Neoplasms; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Mentors; Mission; Modality; Molecular and Cellular Biology; Neoplasms; Peer Review; Postdoctoral Fellow; Procedures; Progress Reports; Prostate; Prostatic; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Role; Site Visit; Students; Summary Reports; Teleconferences; Telephone; Work; anticancer research; carcinogenesis; diverse data; graduate student; interdisciplinary approach; meetings; molecular pathology; mouse model; pre-clinical; programs; support network; synergism; transcriptome sequencing; translational approach; tumor microenvironment; virtual; working group; Address; Atlases; Automobile Driving; Basic Science; Collaborations; Communication; Communities; DNA Methylation; Data Analyses; Data Collection; Data Coordinating Center; Discipline; Electronic Mail; Evaluation; Evolution; Fibroblasts; Fostering; Funding; GSTP1 gene; Genomics; Grant; Human Resources; Individual; Indolent; Inflammation; Infrastructure; Institution; Joints; Knowledge; Leadership; Lesion; Malignant Neoplasms; Malignant neoplasm of prostate; Malignant neoplasm of urinary bladder; Mentors; Mission; Modality; Molecular and Cellular Biology; Neoplasms; Peer Review; Postdoctoral Fellow; Procedures; Progress Reports; Prostate; Prostatic; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Role; Site Visit; Students; Summary Reports; Teleconferences; Telephone; Work; anticancer research; carcinogenesis; diverse data; graduate student; interdisciplinary approach; meetings; molecular pathology; mouse model; pre-clinical; programs; support network; synergism; transcriptome sequencing; translational approach; tumor microenvironment; virtual; working group

Project Summary/Abstract: The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core combine with synergy beyond their individual parts, to contribute to the TBEL Program creating strength beyond the individual Centers, to integrate with the NCI and the cancer research community. The Administrative Core provides the infrastructure essential for this mission. The Core will supervise a multi-component research program encompassing two basic science and one translational projects, and utilizing diverse data collection and analysis modalities. To foster synergy, the Core will be the primary contact for internal activities including logistical and organizational activities, scientific and administrative activities, and collaborative project solicitation, review, funding, and evaluation. To embed our proposed Center within the TBEL Program and the broader cancer research community, this Core will also be the primary contact for external interactions with the NCI, other TBEL Centers, the Coordinating and Data Management Center (CDMC), and external cancer researchers. The Core Leaders, Drs. De Marzo and Yegnasubramanian, have been active collaborators for 19 years, have joint funding on the NCI SPORE grant as well as the NCI MCL grant for the past 6 years and are co-authors on 50 peer-reviewed primary publications and 16 review articles. Drs. De Marzo and Yegnasubramanian are also embedded in internal and external research networks that support their roles. In addition, they have co-mentored several graduate students and post-doctoral fellows, often serving on their fellow graduate student's thesis committees. They have worked together extensively on the molecular pathology and genomics of prostate cancer over the last 10 years, including leading all the RNAseq and whole genomic sequencing efforts for JHU the NCI MCL-U01 projects, including the pre-clinical atlas pilot. Also, together they have worked extensively on the molecular and cellular biology of prostate precursor lesions , together finding partial DNA methylation of GSTP1 in high grade PIN lesions and PIA; a finding directly relevant to the current proposal. Finally, they have worked together extensively, with Dr. Bieberich, on the molecular pathology and genomics of mouse models of prostatic inflammation driven neoplasia and of aggressive versus indolent prostate cancer, and with Dr. Pienta in all administrative aspects and tumor microenvironment studies related to the NCI MCL-U01 Program.

项目摘要/摘要：管理核心的使命是确保单个研究项目以及研究核心与各个部分之外的协同作用相结合，以促进TBEL计划，从而在各个中心之外创造力量，从而与NCI和癌症研究界集成。行政核心为此任务提供了必不可少的基础设施。核心将监督一个涵盖两个基础科学和一个翻译项目的多组分研究计划，并利用多种数据收集和分析方式。为了促进协同作用，核心将是内部活动的主要接触，包括后勤和组织活动，科学和行政活动以及协作项目招标，审查，资金和评估。为了将我们提出的中心嵌入TBEL计划和更广泛的癌症研究界，该核心也将是与NCI，其他TBEL中心，协调和数据管理中心（CDMC）和外部癌症研究人员进行外部相互作用的主要接触。核心领导人，博士。 De Marzo和Yegnasubramanian在过去的6年中一直是NCI Spore Grant以及NCI MCL赠款的共同资助，在过去的6年中，已有共同的合作伙伴关系，并在50名同行评审的初级出版物和16篇评论文章中都是合着者。博士。 De Marzo和Yegnasubramanian也嵌入了支持其角色的内部和外部研究网络中。此外，他们还为几位研究生和博士后研究员共同担任，经常在其研究生论文委员会中任职。在过去的十年中，他们在前列腺癌的分子病理学和基因组学上进行了广泛的合作，包括领导所有RNASEQ和整个基因组测序工作，用于JHU NCI MCL-U01项目，包括临床前的Atlas Pilot。同样，它们共同在前列腺前体病变的分子和细胞生物学上进行了广泛的研究，共同发现了高级引脚病变和PIA中GSTP1的部分DNA甲基化。与当前建议直接相关的发现。最后，他们与Bieberich博士一起进行了广泛的合作，研究了前列腺炎症的小鼠模型的分子病理学和基因组学驱动的肿瘤，侵略性和顽固的前列腺癌，以及与NCI MCL-U01计划有关的所有行政方面和肿瘤微环境研究中的Pienta博士。