Collaborative Microbial Metabolite Center

微生物代谢物协作中心

• 批准号: 10512719
• 负责人: PIETER C DORRESTEIN
• 金额: $ 21.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10512719
• 关键词: Address; Archaea; Bacteria; Bacteriophages; Beverages; Biological; Biological Assay; Characteristics; Collaborations; Communication; Communities; Community Outreach; Data; Deposition; Development; Diet; Digestion; Documentation; Eating; Ecosystem; Educational workshop; Ensure; FAIR principles; Food; Foundations; Gene Cluster; Goals; Health; Hour; Human; Individual; Information Resources; Infrastructure; Inhalation; Internet; Knowledge; Knowledge Management; Link; Mass Spectrum Analysis; Metabolism; Metadata; Microbe; Molecular; Molecular Structure; National Institute of Diabetes and Digestive and Kidney Diseases; Natural Products; Organ; Participant; Pharmaceutical Preparations; Plasticizers; Process; Proteins; Research; Research Personnel; Resources; Skin; Source; Structure; Time; Training; Work; Xenobiotics; data ecosystem; data repository; data sharing; data submission; data visualization; experience; fungus; genetic element; human microbiota; improved; innovation; interoperability; knowledge base; knowledge hub; knowledgebase; meetings; metabolomics; microbial; microbiome; microbiome analysis; nutrition; phenotypic data; pollutant; precision medicine; resilience; small molecule; social; tool; tool development; training opportunity; web interface; web portal

Project Summary/Abstract The interaction between our diet, metabolism by the microbiome, and the downstream biological effects on the host are key foundational knowledge that will guide the development of precision medicine integrated with nutrition. To characterize the function of these individual metabolites that are transformed from foods or fully synthesized by the microbiome will improve the mechanistic understanding of Microbe-Diet-Host interactions. Despite this importance, the community lacks a knowledge management center that centralizes and aggregates bioactivity and function of these metabolites that hinders the ability of researchers to reuse knowledge in a high throughput fashion and build off the discoveries of others. The proposed “Collaborative Microbial Metabolite Center” or CMMC proposed here will fill this void in the scientific landscape, aiming to integrate microbial metabolite discovery and activity from PAR-21-253 grantees and the broader microbial metabolomics community. The CMMC will build a centralized microbial metabolites bioactivity knowledge base that aims to work with the grantees and community to define standards to represent bioactivity, handle community depositions of knowledge and supporting raw data, aggregate depositions into corroborated knowledge, apply knowledge to new data, propagate knowledge into previous uncharacterized molecules, and integrate with other community knowledgebases that host complementary knowledge for microbial metabolites. All data, knowledge, and tools will be made findable, accessible, interoperable, and reusable (FAIR). This proposal will 1) Build the web portal for microbial metabolites with search, export, and analysis functions. 2) Build a microbial metabolite knowledgebase with the accompanying R01 grantees, NIDDK, and the larger scientific community. 3) Coordinate data sharing activities, training and technical support and organize a yearly meeting. The PIs and Co-Is are well suited to address the needs and build the proposed knowledge base, due to their expertise in microbial metabolomics (Dorrestein), microbiome (Dorrestein, Knight), knowledge base creation (Dorrestein, Wang, Knight, Bandeira), community outreach (Dorrestein, Wang), platform training (Dorrestein, Wang), community tool integration (Wang), community knowledgebase integration (Dorrestein, Wang, Knight, Bandeira), scalable tool development (Wang, Bandeira), and data resiliency (Wang, Bandeira).

项目摘要/摘要 我们的饮食，微生物组的代谢与下游生物学作用之间的相互作用 主机上的主要基础知识将指导精确医学的发展 营养。表征这些从食物转化或 由微生物组完全合成的将提高对微生物宿主的机械理解 互动。尽管很重要，但社区缺乏知识管理中心，以集中 并汇总了这些代谢产物的生物活性和功能，从而阻碍了研究人员重复使用的能力 以高通量方式的知识并建立了他人的发现。拟议的“合作” 微生物代谢中心”或此处提出的CMMC将在科学景观中填补这一空白，以此目的 PAR-21-253 Grandees和更广泛的微生物的集成微生物代谢物发现和活动 代谢组学社区。 CMMC将建立一个集中的微生物代谢物生物活性知识库 旨在与大人和社区合作，以定义代表生物活性，处理生物活性的标准 知识的社区证词和支持原始数据，汇总沉积为佐证 知识，将知识应用于新数据，将知识传播到以前的未表征分子中，并且 与其他社区知识库集成，这些知识基于微生物代谢物的互补知识。 所有数据，知识和工具都将被发现，可访问，可互操作和可重复使用（公平）。 该建议将1）通过搜索，出口和分析构建微生物代谢物的Web门户网站 功能。 2）与参与的R01 Grandtees，Niddk和 更大的科学界。 3）协调数据共享活动，培训和技术支持并组织 年度会议。 PIS和CO-IS非常适合满足需求并建立拟议的知识库 他们在微生物代谢组学（Dorrestein），微生物组（Dorrestein，Knight），知识库方面的专业知识 Creation（Dorrestein，Wang，Knight，Bandeira），社区外展（Dorrestein，Wang），平台培训 （Dorrestein，Wang），社区工具集成（Wang），社区知识基础（Dorrestein，Dorrestein， Wang，骑士，Bandeira），可扩展工具开发（Wang，Bandeira）和数据弹性（Wang，Bandeira）。