UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations (UC END-DISPARITIES)

加州大学洛杉矶分校-UCI 消除多种族人群心脏代谢差异中心 (UC END-DISPARITIES)

• 批准号: 10494277
• 负责人: BERNADETTE Marie BODEN-ALBALA
• 金额: $ 350.24万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494277
• 关键词: Address; Affect; Aging; American Indians; Asian Pacific Islander; Atherosclerosis; Award; Biometry; Black race; California; Cardiometabolic Disease; Cardiovascular system; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical Research; Clinical Sciences; Communication; Communities; Community Health Systems; Complications of Diabetes Mellitus; County; Data Set; Development; Diabetes Mellitus; Disadvantaged; Discrimination; Disease Clusterings; Ethnic group; Evaluation; Family; Funding; Future; Goals; Health; Health Policy; Health system; Hypertension; Individual; Infrastructure; Institutes; Intervention; Latino; Link; Los Angeles; Low income; Measurement; Measures; Mentors; Mentorship; Methodology; Minority; Minority Groups; Minority Health Research; Minority-Serving Institution; Morbidity - disease rate; National Institute of General Medical Sciences; National Institute on Minority Health and Health Disparities; Oranges; Outcome; Outcome Measure; Outcomes Research; Pacific Island Americans; Participant; PhenX Toolkit; Pilot Projects; Population; Postdoctoral Fellow; Public Health; Reduce health disparities; Research; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Risk Factors; Stress; Training; Training Programs; Translational Research; United States National Institutes of Health; Work; allostatic load; behavioral economics; cardiometabolic risk; cardiometabolism; care outcomes; career; catalyst; community engagement; data harmonization; data sharing; design; disease disparity; disorder prevention; flexibility; health disparity; health equity; health information technology; implementation science; improved; inflammatory marker; innovation; marginalized population; meetings; minority communities; mortality; multi-ethnic; patient population; premature; prevent; programs; social; social genomics; social health determinants; synergism; therapy design; tool; vulnerable community

Project Summary/Abstract P50 UC END-DISPARITIES UC END-DISPARITIES will address the inequitable multilevel factors that promote cardiometabolic disease, including hypertension, diabetes, and complications such as atherosclerotic vascular disease and chronic kidney disease. These conditions are highly influenced by structural disadvantage and disproportionately affect low-income, minoritized, and other marginalized groups in the highly diverse and contiguous region of Los Angeles County (LAC) and Orange County (OC) (combined population over 13M; > 46 states). The Center will fill a gap in the current efforts to advance health equity via a multilevel community-academic partnered approach to improve cardiometabolic related health outcomes in targeted LAC and OC Latino, Black, Asian, Pacific Islander, and American Indian communities, which have some of the highest rates of cardiometabolic risk factors and premature cardiovascular morbidity and mortality in the nation. UC END-DISPARITIES will function through three highly integrated cores and three inaugural center research projects across southern California, all supporting Pilot Awards and Community Catalyst Awards, while leveraging synergies with key community-academic networks, community, public health, and health system stakeholders, regional networks of minority-serving institutions, centers at UCLA and UCI for clinical and translational science, and methodologic leaders with expertise in health equity research, biostatistics, implementation science, and health information technology. The Administrative Core, Investigator Development Core, and Community Engagement Core will implement the following Center objectives: 1) Provide administrative and operational support for all activities and collaborate with the NIMHD Chronic Disease Disparities Coordinating Center; 2) Develop the requisite community-academic research infrastructure to improve the health of the diverse multiethnic communities of LAC and OC through multilevel interventions; 3) Broaden/enhance existing and new partnerships with communities to expand the pool of diverse participants in research and recipients of findings for UC END DISPARITIES and related funded entities; 4) Promote successful training and academic advancement of underrepresented post-doctoral and early career investigators through mentorship, opportunities to participate in community engaged health interventions, and support of pilot projects and subsequent independent cardiometabolic disparities research; 5) Conduct rigorous analyses and partner with community stakeholders to identify community, health system, family, and individual-level correlates of health disparities to inform research methods, health policy, and the design of community and health system partnered interventions to mitigate cardiometabolic disparities; and 6) Contribute to the development, evaluation, and dissemination of valid, reliable, and generalizable tools that can measure and track health outcomes and the social, behavioral, and economic predictors relevant to multiethnic communities at risk for cardiometabolic disease.

项目摘要/摘要 P50 UC末端分配 UC终端分配将解决促进心脏代谢疾病的不平等多层次因素， 包括高血压，糖尿病和并发症，例如动脉粥样硬化血管疾病和慢性 肾脏疾病。这些条件受结构劣势的高度影响，并且影响不成比例 LOS高度多样化和连续区域中的低收入，少数和其他边缘化组 安吉尔斯县（LAC）和奥兰治县（OC）（超过13m的人口；> 46个州）。中心将 填补当前通过多级社区学术伙伴促进健康公平的努力的空白 改善目标LAC和OC Latino，Black，Asian， 太平洋岛民和美洲印第安人社区的心脏代谢率最高 全国的风险因素和过早的心血管发病率和死亡率。 UC最终区域会 通过三个高度集成的核心和三个开幕式研究项目的功能 南加州，所有支持飞行员奖和社区催化剂奖，同时 与关键社区学术网络，社区，公共卫生和卫生系统利益相关者的协同作用， 少数民族服务机构的区域网络，UCLA和UCI的中心用于临床和转化 科学和方法论领导者具有健康公平研究，生物统计学，实施方面的专业知识 科学和健康信息技术。行政核心，调查员发展核心以及 社区参与核心将实施以下中心目标：1）提供行政 以及对所有活动的运营支持，并与NIMHD慢性疾病差异合作 协调中心； 2）开发必要的社区学术研究基础设施以改善 通过多层次干预措施的多样化lac和oc的多民族社区的健康； 3） 扩大/增强与社区的现有和新的合作伙伴关系，以扩大各种各样的库 参与UC最终差异和相关资助实体的研究结果的参与者； 4）促进代表性不足后和早期的成功培训和学术进步 通过指导，参加社区参与健康的机会的职业调查员 试点项目的干预和支持以及随后的独立心脏代谢差异 研究; 5）进行严格的分析并与社区利益相关者合作以识别社区， 卫生系统，家庭和个人级别的健康差异相关性，以告知研究方法， 卫生政策以及社区和卫生系统的设计合作进行干预措施以减轻 心脏代谢差异； 6）为有效的开发，评估和传播做出贡献， 可靠且可概括的工具，可以衡量和跟踪健康成果以及社会，行为， 以及与具有心脏代谢疾病风险的多种族社区有关的经济预测因素。