UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations

加州大学洛杉矶分校-加州大学尔湾分校消除多种族人群心脏代谢差异中心

• 批准号: 10494288
• 负责人: BERNADETTE Marie BODEN-ALBALA
• 金额: $ 71.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494288
• 关键词: Ethnic group; cardiometabolism; multi-ethnic

PROJECT SUMMARY Stroke and cardiovascular disease account for 1 in 4 deaths among Latinos in the U.S, and heart disease is the second leading cause of death overall. Vietnamese populations in southern CA have persistently high rates of hypertension linked to elevated rates of stroke. Hypertension disproportionately affects communities of color who are often concentrated residentially due to race-based residential segregation. Disinvestment in the social, economic, and physical environment in communities of color enhances barriers to cardiovascular disease risk prevention and management. These disparities, along with the continued growth of diverse populations in southern California and across the U.S., highlight the need for novel, community-level interventions to prevent hypertension. Primordial prevention of hypertension is critical in moving forward in terms of the achievement of ideal cardiovascular health cardiovascular health for all. There is growing evidence that integrating families and social networks into behavioral interventions may enhance the efficacy, effectiveness and sustainability of vascular risk reduction. The Skills-based Educational strategies to Reduce Vascular Events in Orange County (SERVE OC) intervention is a culturally-tailored, skills-based educational program set within a supportive family structure and utilizing a community health worker model. Our hypothesis is that this approach will optimize successful long-term behavioral change for prevention of hypertension among adults and children in Vietnamese and Latino households in Orange County, CA. This hypothesis is supported by significant formative research, including our original Discharge Educational Strategies for Reduction of Vascular Events (DESERVE) intervention randomized control trial. DESERVE shifted the paradigm for vascular risk reduction strategies by translating information to skills-based actions resulting in a clinically significant reduction in systolic blood pressure overall and a statistically significant reduction in systolic blood pressure among Latinos. DESERVE also found that blood pressure reduction was enhanced among those with stronger support networks. This proposal seeks to test with SERVE OC whether we can optimize, through adaptation, the DESERVE intervention model for blood pressure reduction by using family networks as a platform to deliver primary prevention of hypertension.

项目概要 中风和心血管疾病占美国拉丁裔死亡人数的四分之一，而心脏病是 总体死亡原因的第二大原因。加利福尼亚州南部的越南人口比例持续居高不下 高血压与中风发病率升高有关。高血压对有色人种的影响尤为严重 由于基于种族的居住隔离，他们经常集中居住。社会投资减少， 有色人种社区的经济和自然环境增强了心血管疾病风险的障碍 预防和管理。这些差异以及不同人口的持续增长 南加州和美国各地强调需要采取新颖的社区一级干预措施来预防 高血压。高血压的初级预防对于实现以下目标至关重要 理想的心血管健康 所有人的心血管健康。越来越多的证据表明，家庭和 将社交网络纳入行为干预可能会提高行为干预的功效、有效性和可持续性 降低血管风险。奥兰治县减少血管事件的基于技能的教育策略 (SERVE OC) 干预是一项根据文化量身定制、以技能为基础的教育计划，设置在支持性的框架内 家庭结构和利用社区卫生工作者模式。我们的假设是这种方法将 优化成功的长期行为改变，以预防成人和儿童的高血压 加利福尼亚州奥兰治县的越南人和拉丁裔家庭。这一假设得到了重要的支持 形成性研究，包括我们原创的减少血管事件的出院教育策略 （值得）干预随机对照试验。 DESERVE 改变了降低血管风险的范式 通过将信息转化为基于技能的行动的策略，从而在临床上显着减少 总体收缩压，拉丁裔的收缩压在统计上显着降低。 DESERVE 还发现，在获得较强支持的人中，血压降低效果增强 网络。该提案旨在通过 SERVE OC 测试我们是否可以通过适应来优化 DESERVE 降低血压干预模式，以家庭网络为平台 高血压的一级预防。