HomeStyles: Shaping HOME Environments and LifeSTYLE Practices to Reduce Cardiometabolic Disease Risk

家居风格：塑造家庭环境和生活方式实践以降低心血管代谢疾病风险

• 批准号: 10494161
• 负责人: Debra Carol Byrd-Bredbenner
• 金额: $ 67.53万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494161
• 关键词: Address; Adopted; Adult; Advisory Committees; Anti-Inflammatory Agents; Asian; Asian population; Attenuated; Awareness; Bacteria; Behavior; Behavior Therapy; Behavioral; Body mass index; Cardiometabolic Disease; Characteristics; China; Chinese; Chinese population; Chronic Disease; Clinical Trials; Communities; Consumption; Country; Diabetes Mellitus; Diet; Dietary Fiber; Dietary Intervention; Dietary intake; Disease Progression; Endotoxins; Ethnic Origin; Family; Fiber; Focus Groups; Food; Generations; Glycosylated hemoglobin A; Goals; Health; Health Food; Health Promotion; Health Status; Health behavior; Home environment; Homeostasis; Hypertension; Immigration; Individual; Inflammation; Inflammatory; Interruption; Intervention; Intervention Studies; Interview; Knowledge; Lead; Life Style; Linguistics; Link; Measures; Minority Groups; Modeling; National Institute on Minority Health and Health Disparities; New Jersey; New York; Noise; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Obesity; Onset of illness; Outcome; Overweight; Participant; Patient Self-Report; Physical activity; Physiological; Play; Populations at Risk; Preventive service; Psychosocial Stress; Race; Randomized; Reporting; Research; Research Project Grants; Risk; Risk Factors; Role; Self Efficacy; Shapes; Sleep; Sleep Deprivation; Spouses; Testing; Treatment Efficacy; United States Department of Agriculture; World Health Organization; arm; base; cardiometabolic risk; cardiometabolism; clinically significant; cognitive interview; comorbidity; cytokine; disorder risk; efficacy testing; evidence base; fruits and vegetables; group intervention; gut bacteria; gut health; gut microbiome; gut microbiota; health disparity; health equity; health inequalities; healthy lifestyle; improved; informant; interest; microbiome; modifiable risk; multi-component intervention; nutrition; obesity risk; pathobiont; physical inactivity; protective factors; sleep behavior; social cognitive theory; social health determinants; sociodemographics; sugar; systemic inflammatory response; treatment group; waist circumference

Research Project 1 – HomeStyles – Abstract Individuals of Chinese heritage now are the largest and fastest growing segment of the US Asian population. US Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and therefore, differ in social determinants of health, health status, and disease risk. US Chinese adults are at increased risk for cardiometabolic disease, related conditions (obesity, type 2 diabetes mellitus, hypertension), and systemic inflammation that promotes disease onset and progression. Immigration to a new country can substantially impact the gut microbiome which may promote systemic inflammation. Our pilot interventions indicate a high-fiber diet rich in whole grains reduced inflammation and improved obesity. Additionally, our USDA supported, evidence based HomeStyles intervention has demonstrated feasibility, acceptability, and efficacy in improving lifestyle behaviors and home environments associated with obesity risk in families. A lack of linguistically, culturally tailored interventions to their specific health needs makes it difficult for US Chinese to implement healthy lifestyle behaviors and reduce health risks. We are not aware of any intervention tailored for US Chinese that could attenuate modifiable cardiometabolic risk factors, understand physiological sequelae, and bridge health equity. Thus, the overall goal of this R01 proposal is to test the efficacy of HomeStyles in improving health outcomes in US Chinese in NY/NJ. Proposal aims are to: A) Culturally adapt the HomeStyles intervention through community-engaged approaches. B) Conduct a 10-week, 2-armed RCT to test HomeStyles intervention efficacy on health outcomes (dietary intake, physical activity, self-efficacy, HbA1C, waist circumference, and BMI), hypothesizing that participants randomized to the treatment condition will have greater improvements in health outcomes than control comparators. C) Examine associations between intervention participation and gut microbiota/systemic inflammation and test hypotheses that a whole-grain rich diet adopted by those in the intervention group will increase anti-inflammatory gut bacteria, reduce inflammatory gut bacteria, and lower systemic inflammation. This proposal’s aims parallel NIMHD’s specific interests, as well as RFA MD-21-007. This includes interventions, like HomeStyles, that aim to ameliorate health inequities in minority populations and reduce multiple common risk factors (e.g., obesity, poor nutrition, physical inactivity, insufficient sleep, systemic inflammation) for multiple chronic diseases as well as address multi-generational chronic disease risk and protective factors. A culturally adapted HomeStyles intervention holds great potential for improving our knowledge about health disparity in the US Chinese population, understanding translational mechanisms toward comorbidities, informing family and community-oriented interventions through sustainable engagement, and serving as a model for health interventions for this audience.

研究项目1 - 家庭风格 - 摘要 现在，中国遗产的个人是美国亚洲人口中最大，最快的人群。我们 中国人的社会人口统计学特征和文化与其他亚洲人有很大不同， 因此，健康，健康状况和疾病风险的社会决定者不同。美国中国成年人在 心脏代谢疾病，相关疾病（肥胖，2型糖尿病，高血压）的风险增加 以及促进疾病发作和进展的全身性炎症。移民到一个新国家可以 大大影响肠道微生物组，这可能促进全身炎症。 我们的飞行员干预措施表明，富含全谷物的高纤维饮食减少了注射和 改善肥胖。此外，我们的美国农业部支持，基于证据的居家干预已经 在改善生活方式和家庭方面表现出可行性，可接受性和效率 与家庭肥胖风险相关的环境。缺乏语言，文化量身定制的干预措施 满足他们特定的健康需求，使美国中国人难以实施健康的生活方式行为并减少 健康风险。我们不知道为美国中国量身定制的任何干预措施可以减弱可修改 心脏代谢风险因素，了解身体后遗症和桥梁健康公平。 这是该R01提案的总体目标是测试居家的效率，以改善健康状况 美国纽约州/新泽西州中国人的成果。建议的目的是：a）文化适应居家的干预措施 通过社区参与的方法。 b）进行为期10周的2臂RCT测试Homestyles干预 对健康结果的疗效（饮食摄入，体育锻炼，自我有效，HBA1C，腰围和 BMI），假设参与者随机将治疗条件随机化将有更大的改善 健康结果比控制比较者。 c）检查干预参与与肠道之间的关联 微生物群/全身注射和检验假设，该假设是在 干预组将增加抗炎肠道细菌，减少炎症肠道细菌，并降低 系统性炎症。 该提案的目标是NIMHD并行的特定利益，以及RFA MD-21-007。这包括 旨在减轻少数族裔的健康摄入并减少的干预措施，例如家庭风格 多种常见的危险因素（例如肥胖，营养不良，身体不活跃，睡眠不足，全身性 炎症）用于多种慢性疾病，并针对多代慢性疾病风险和 保护因素。具有文化适应的居家干预具有改善我们的巨大潜力 关于美国中国人口健康差异的知识，了解翻译 合并症的机制，通过 可持续的参与度，并作为该受众的健康干预措施的典范。