IMPACT Project 4 – Budget impact, cost-effectiveness, and population outcomes of interventions to improve HPV vaccine communication and uptake in rural and nonrural communities

IMPACT 项目 4 — 改善农村和非农村社区 HPV 疫苗传播和采用的干预措施的预算影响、成本效益和人口结果

• 批准号: 10493194
• 负责人: Sachiko Ozawa
• 金额: $ 35.26万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493194
• 关键词: Address; Administrator; Adoption; Advanced Malignant Neoplasm; Affect; Area; Clinical; Communication; Communities; County; Data; Decision Aid; Decision Making; Educational Intervention; Effectiveness; Evidence based intervention; Feedback; Geography; Goals; Health; Health system; Healthcare Systems; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Intervention; Intervention Studies; Interview; Malignant Neoplasms; Methods; Modeling; North Carolina; Online Systems; Outcome; Pattern; Population; Primary Health Care; Program Research Project Grants; Provider; Research; Rural; Sampling; Science; Social Environment; Structure; Surveys; Testing; Training; Training Programs; Translating; Vaccination; Wisconsin; Work; budget impact; cancer prevention; comparative; contextual factors; cost; cost effectiveness; evidence base; implementation context; implementation cost; implementation intervention; implementation outcomes; improved; innovation; intervention cost; intervention program; member; motivational enhancement therapy; novel; population health; prevent; programs; rural area; rural setting; support tools; tool; training project; transmission process; uptake; usability; web site

ABSTRACT – Project 4 Human papillomavirus (HPV) cancers are preventable through vaccination. Yet HPV vaccine coverage is well below the national goal of 80%, especially in rural areas where HPV cancers are more common. HPV vaccine communication interventions are a promising approach to address low uptake. As part of the P01 Program Project, “Improving Provider Announcement Communication Training (IMPACT),” Projects 1-3 will test novel enhancements of the Announcement Approach Training (AAT) intervention in healthcare systems to improve primary care team members' HPV vaccine communication. The overall objective of Project 4 is to facilitate decision makers' selection and adoption of AAT and other effective HPV vaccination interventions, by quantifying tradeoffs in their comparative cost and health impact in rural and nonrural areas. Aim 1 is to identify differences in contextual factors in rural and nonrural clinical settings that may influence the implementation and effectiveness of enhanced AAT interventions. Using a mixed-methods approach, we will conduct semi-structured interviews in rural (n=20) and nonrural areas (n=20) among primary care team members, quality improvement decision makers, and health administrators, as well as survey a national sample of primary care team members (n=2,500) to examine contextual differences across rural and nonrural clinical settings. Aim 2 is to evaluate the budget impact, cost-effectiveness, and population outcomes of HPV vaccine communication and other evidence-based interventions in rural and nonrural clinical settings, including the enhanced AAT interventions studied in Projects 1-3, to facilitate comparisons for decision making. We will develop a national county-specific HPV microsimulation model that overlays interventions onto populations reflecting patterns of baseline HPV vaccination, HPV transmission, and progression to HPV cancers to project the anticipated budget impact, cost-effectiveness, and population outcomes of HPV vaccine interventions in rural and nonrural clinical settings. Aim 3 is to aid stakeholder implementation planning by developing a web-based interactive decision support tool illustrating the value and implementation outcomes of HPV vaccine interventions in rural and nonrural clinical settings. We will engage stakeholders to evaluate the usability of the decision support tool for decision making and add to the AAT Intervention Package. Project 4 addresses the IMPACT Program Project theme of amplifying HPV vaccine communication interventions' impact in healthcare systems. Our project findings will translate the health impact and cost of interventions tested in Projects 1-3 in rural and nonrural areas into a dissemination format well-suited to the needs of decision makers in healthcare systems to accelerate the adoption of promising HPV vaccine communication interventions to prevent cancer in diverse geographic contexts.

摘要 – 项目 4 人乳头瘤病毒 (HPV) 癌症可以通过疫苗接种来预防，但 HPV 疫苗的覆盖率较低。 远低于 80% 的国家目标，尤其是在 HPV 癌症更为常见的农村地区。 作为 P01 的一部分，疫苗传播干预措施是解决低接种率问题的一种有前途的方法。 计划项目，“改进提供商公告沟通培训 (IMPACT)”，项目 1-3 将 测试医疗保健系统中公告方法培训 (AAT) 干预的新颖增强功能， 改善初级保健团队成员的 HPV 疫苗沟通 项目 4 的总体目标是： 促进决策者选择和采用 AAT 和其他有效的 HPV 疫苗接种 通过量化农村和非农村地区相对成本和健康影响的权衡来制定干预措施。 目标 1 是确定农村和非农村临床环境中背景因素的差异，这些差异可能 使用混合方法影响强化 AAT 干预措施的实施和有效性。 方法，我们将在农村（n = 20）和非农村地区（n = 20）的小学中进行半结构化访谈 护理团队成员、质量改进决策者和健康管理者，以及一项调查 全国初级保健团队成员样本（n = 2,500），以检查农村和农村地区的背景差异 目标 2 是评估预算影响、成本效益和人口。 农村和非农村地区 HPV 疫苗宣传和其他循证干预措施的结果 临床环境，包括项目 1-3 中研究的增强 AAT 干预措施，以促进比较 我们将开发一个覆盖全国各县的 HPV 微观模拟模型。 反映基线 HPV 疫苗接种、HPV 传播和 HPV 癌症的进展，以预测预期的预算影响、成本效益和人口 农村和非农村临床环境中 HPV 疫苗干预的结果是帮助利益相关者。 通过开发基于网络的交互式决策支持工具来说明实施规划 HPV 疫苗干预措施在农村和非农村临床环境中的价值和实施结果。 让利益相关者评估决策支持工具的可用性，并添加到决策中 AAT 干预方案 4 涉及放大 HPV 的 IMPACT 项目主题。 我们的项目研究结果将转化为疫苗传播干预措施对医疗保健系统的影响。 项目 1-3 中测试的干预措施在农村和非农村地区传播的健康影响和成本 格式非常适合医疗保健系统决策者的需求，以加速采用 HPV 疫苗传播干预措施可预防不同地理环境中的潜在癌症。