KPMP Kidney Mapping and Atlas Project (KMAP)

KPMP 肾脏绘图和图集项目 (KMAP)

• 批准号: 10492787
• 负责人: Jonathan Himmelfarb
• 金额: $ 196万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492787
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Anatomy; Atlases; Bioinformatics; Biometry; Biopsy; Cells; Chronic Kidney Failure; Clinical; Collaborations; Communities; Community Outreach; Data; Data Analyses; Data Display; Data Set; Data Storage and Retrieval; Disease; Ecosystem; Ensure; Environment; FAIR principles; Funding; Future; Generations; Goals; Health; Human BioMolecular Atlas Program; Institution; Joints; Kidney; Kidney Diseases; Knowledge; Lead; Leadership; Maps; Metadata; Michigan; Molecular; Nephrology; Ontology; Participant; Pathologist; Pathology; Pathway interactions; Patients; Phase; Philosophy; Plant Roots; Process; Quality Control; Research; Research Personnel; Risk; Role; Route; Science; Services; Site; Stratification; Structure; Students; System; Systems Biology; Tissue atlas; Tissues; Universities; Washington; cloud based; collaborative environment; computerized data processing; data curation; data dissemination; data integration; data management; data modeling; data visualization; design; digital pathology; disorder subtype; diversity and equity; experience; flexibility; genomic data; indexing; interstitial; multimodal data; multimodality; nephrogenesis; new therapeutic target; outreach; participant safety; patient engagement; precision medicine; recruit; research study; response; skills; social; software development; structured data; success; tool; website development

ABSTRACT The overarching objective of the Kidney Mapping Atlas Project (KMAP) in response to the Kidney Tissue Atlas Coordinating Center (KTACC) application is to create and support the central data management, integration and dissemination platform for the Kidney Precision Medicine Project (KPMP). Our focus for the KMAP will be centered around the key values established by us in the first funding cycle of KPMP: a collaborative environment committed to promoting participant safety and engagement, scientific rigor, and outreach to the global renal research community anchored in a concept of interdisciplinary team science necessary to drive disruptive advances in kidney precision medicine. We plan to extend our highly experienced team successfully navigating the multiple inherent challenges during the startup phase of KPMP to address the key opportunities and challenges of the next phase of KPMP. To this end have assembled domain expertise in nephrology, nephro- and digitial pathology, anatomy, ontology, data curation, biostatistics, bioinformatics, renal systems biologists, data visualization, kidney user experience, website and software development. Our overarching principle will continue to be an uncompromising commitment to our patient partners co-leading our efforts and a sharp focus on rigorous QC and QC in tight coordination with the KPMP Central Hub, the Tissue Interrogation and Recruitment Sites and Opportunity pool awardees. We have pioneered a team science structure to advance a precision medicine approach to kidney disease with the development of the KPMP data management, integration and sharing framework strongly routed in FAIR principles. We share a common philosophy that our role is one of service, collaboration, and leadership with over 30 years of experience coordinating highly successful large-scale research studies into the molecular mechanism of kidney disease always supporting diversity, equity and inclusion in all aspects of renal precision medicine research. The KMAP will be led by Drs. Kretzler (University of Michigan) and Himmelfarb (University of Washington) with complementary expertise and an extensive track record in working together to lead clinical, translational and bench kidney precision medicine studies and will ensure the seamless integration of KMAP into the KPMP ecosystem. KMAP will serve its function via three main units. The KMAP Data Management Core (DMC) will be responsible to clean, harmonize, register, store and curate the diverse current and future KPMP data. The KMAP Data Analysis Hub (DAH) will integrate the multimodal data along the continuum of clinical, social-risk, spatial, ontological, digital-pathology and molecular data sets to identify key drivers of disease processes. Finally, the KMAP Data Visualization Hub (DAV) will develop, maintain and distribute a multi-dimensional atlas of kidney health and disease via a flexible computation environment. Tight integration of the KMAP efforts with HuBMAP, HCA and RBK/GUDMPA together with strong leadership skills of the PIs will ensure effective implementation across KPMP and the biomedical community at large.

抽象的 肾脏绘图图谱项目 (KMAP) 的总体目标是响应肾脏组织图谱 协调中心（KTACC）应用程序是创建和支持中央数据管理、集成 肾脏精准医学项目（KPMP）的传播平台。我们 KMAP 的重点是 围绕我们在 KPMP 第一个资助周期中确立的关键价值观：协作 环境致力于促进参与者的安全和参与、科学严谨性以及推广 全球肾脏研究界以跨学科团队科学的概念为基础，以推动 肾脏精准医学的颠覆性进展。我们计划成功扩展我们经验丰富的团队 应对 KPMP 启动阶段的多重固有挑战，抓住关键机遇 以及KPMP下一阶段的挑战。为此，我们汇集了肾脏病学领域的专业知识， 肾病和数字病理学、解剖学、本体论、数据管理、生物统计学、生物信息学、肾脏系统 生物学家、数据可视化、肾脏用户体验、网站和软件开发。我们的首要任务 原则将继续是对我们的患者合作伙伴的坚定承诺，共同领导我们的努力和 高度重视严格的质量控制，并与 KPMP 中央中心、组织机构密切协调 审讯和招聘网站以及机会池获奖者。 我们开创了一个团队科学结构，以推进肾脏疾病的精准医学方法 KPMP 数据管理、集成和共享框架的开发在 FAIR 中得到大力支持 原则。我们有一个共同的理念，即我们的角色是服务、协作和领导 拥有 30 多年协调非常成功的大规模分子研究的经验 肾脏疾病机制始终支持肾脏精准各个方面的多样性、公平性和包容性 医学研究。 KMAP 将由 Drs 领导。 Kretzler（密歇根大学）和 Himmelfarb（大学） 华盛顿）具有互补的专业知识和在合作领导方面的广泛记录 临床、转化和实验室肾脏精准医学研究，并将确保无缝整合 KMAP 融入 KPMP 生态系统。 KMAP 将通过三个主要单位发挥其作用。 KMAP 数据管理核心 (DMC) 将 负责清理、协调、注册、存储和管理当前和未来的各种 KPMP 数据。这 KMAP 数据分析中心 (DAH) 将整合临床、社会风险、 空间、本体论、数字病理学和分子数据集，用于识别疾病过程的关键驱动因素。 最后，KMAP 数据可视化中心 (DAV) 将开发、维护和分发多维 通过灵活的计算环境绘制肾脏健康和疾病图谱。 KMAP 工作与 HuBMAP、HCA 和 RBK/GUDMPA 紧密结合，并具有强有力的领导力 PI 的技能将确保 KPMP 和整个生物医学界的有效实施。