Cancer Control and Population Science

癌症控制与人口科学

基本信息

批准号：
10491109
负责人：
SHIRAZ I. MISHRA
金额：
$ 7.05万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-26 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10491109
关键词：
Address Air American Indians Analgesics Anthropology Arizona Arsenic Arts Behavior Therapy Behavioral Behavioral Sciences Bioinformatics Biological Markers Biometry Breast Cancer Center Cancer Center Support Grant Cancer Control Caring Catchment Area Cervical Cancer Screening Cervix Uteri Clinical Clinical Trials Collaborations Colorado Colorectal Colorectal Cancer Communities Community Clinical Oncology Program Community Medicine Community Outreach Comprehensive Cancer Center Contracts Cultural Diversity DNA Damage Data Dermatology Development Disease Doctor of Philosophy Early Diagnosis Education Endometrial Engineering Environmental Exposure Environmental Health Environmental Pollution Environmental Risk Factor Epidemiology Family Practice Funding Future Gallbladder Genetic Genomics Genotype Geography Goals Grant Guidelines Health Services Healthcare Hepatitis C virus Hispanic Hispanic Americans Human Papilloma Virus Vaccination Human Papillomavirus Incidence Infrastructure Internal Medicine Intervention Intervention Studies Journals Ketorolac Kidney Knowledge Length Liver Lung Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of lung Malignant neoplasm of ovary Metals Minority Molecular Molecular Epidemiology Morbidity - disease rate Mutation NCI-Designated Cancer Center New Mexico Not Hispanic or Latino Oncologist Outcome Ovarian Particulate Pathology Patients Pediatrics Peer Review Personal Satisfaction Pharmacy facility Planet Earth Population Population Genetics Population Heterogeneity Population Sciences Populations at Risk Primary Health Care Prostate Publications Publishing Registries Research Research Institute Resource Sharing Resources Risk Risk Behaviors Risk Factors Risk Reduction Rural Rural Community Rural Population Science Screening for cancer Smoker Testing Therapeutic Human Experimentation Tissues Tobacco Training Translations Underserved Population Universities Utah Virus Zinc supplementation base cancer care cancer health disparity cancer risk cellular oncology cohort college colorectal cancer screening community based participatory research community center community engaged research community engagement community intervention cooking dissemination research early detection biomarkers evidence base follow-up health disparity health economics implementation research improved improved outcome male medical schools melanoma member methylation biomarker molecular oncology mortality mortality disparity multi-ethnic neoplasm registry physical inactivity policy recommendation population based population health programs prospective racial and ethnic ranpirnase respiratory risk prediction screening screening disparities screening guidelines socioeconomics survivorship therapeutic target tribal Nation tumor tumor registry underserved minority working group

项目摘要

ABSTRACT: Cancer Control and Population Sciences (CCPS) is a transdisciplinary research program incorporating expertise in surveillance, epidemiology, population genetics, anthropology, behavioral science, health economics, dissemination and implementation research, biostatistics, health services, and environmental health across the cancer continuum. CCPS serves as the nexus for cancer control and population/community research within the University of New Mexico Comprehensive Cancer Center (UNMCCC) and it’s catchment area, the State of New Mexico (NM) - one of the five ”majority-minority” states in the US. The catchment area’s racial/ethnic diverse population have substantial socioeconomic, healthcare, and geographic challenges, all contributing to tremendous cancer disparities and inequities. Within this context of the catchment area, the overarching goals of CCPS are to conduct high impact research and disseminate interventions to reduce cancer risk, morbidity, mortality and disparity in the multiethnic, culturally diverse, and underserved populations of NM and beyond. To achieve these goals CCPS proposes three specific aims: (1) improve cancer risk prediction and reduce cancer risk; (2) define screening determinants and advance guideline concordant cancer screening; and, (3) define the treatment and behavioral determinants of living with, through, and beyond cancer to improve outcomes, patient well-being, and length of survival. These aims are aligned with two central themes, disparities and interventions, which provide a context and framework for addressing the needs of the catchment area and beyond. Unique strengths and major accomplishments include: early-detection methylation biomarkers associated with lung cancer risk; prospective assessment of the impact of HPV vaccination on cervical cancer incidence; engagement of American Indian communities to enhance colorectal cancer screening and molecular characterization of cancer; and, care transition from oncologists to primary care in rural NM supported by UNM’s Project ECHOTM. CCPS is led by Linda Cook, PhD (molecular epidemiology) and Shiraz Mishra, MBBS, PhD (behavioral /community interventions). CCPS has 29 members (24 Full, 5 Associate) from 6 Departments in the School of Medicine (Internal Medicine, Pediatrics, Family & Community Medicine, Pathology, and Dermatology); the Colleges of Population Health, Pharmacy, and Arts and Sciences (Departments of Engineering and Earth & Planetary Sciences); and the Lovelace Respiratory Research Institute. As of 9/1/2020, CCPS has $17.5M in total annual direct funding; $11.1M is peer-reviewed, and $2.5M is from the NCI. Additionally, CCPS has $2.7M in annual NCI direct funding through the NCI SEER contract for the New Mexico Tumor Registry and CCSG Supplements. The discoveries made in CCPS have resulted in 336 publications, of which 24% were intra-programmatic collaborations, 20% were inter-programmatic collaborations, 60% were collaborations with other cancer centers nationally, and 12% were published in high impact journals. CCPS has conducted 28 intervention studies with 1629 accruals.

摘要：癌症控制和人口科学（CCP）是一项跨学科研究计划纳入监视，流行病学，人口遗传学，人类学，行为科学，卫生经济学，传播和实施研究，生物统计学，卫生服务和环境整个癌症连续性的健康。 CCP是癌症控制和人群/社区的联系新墨西哥大学综合癌症中心（UNMCCC）及其集水区的研究新墨西哥州（新墨西哥州）地区 - 美国五个“多数级”国家之一。集水区的种族/种族多样性人口具有实质性的社会经济，医疗保健和地理挑战导致巨大的癌症差异和不平等。在集水区的这种情况下 CCP的总体目标是进行高影响研究并传播干预措施以减少癌症 NM的多种族，文化潜水员和服务不足的人口的风险，发病率，死亡率和差异及以后。为了实现这些目标，CCP提案三个具体目标：（1）改善癌症风险预测和降低癌症风险；（2）定义筛查确定并提前指导癌症筛查；和，（3）定义与癌症，通过和超越癌症生活的治疗和行为决定者结果，患者福祉和生存时间。这些目标与两个中央主题一致，分布和干预措施，这些干预措施提供了一个环境和框架，以满足集水区的需求和超过。独特的优势和主要成就包括：早期检测甲基化生物标志物与肺癌风险相关；对HPV疫苗接种对宫颈癌的影响的前瞻性评估发病率；美洲印第安人社区的参与以增强结直肠癌筛查和分子癌症的表征；而且，由UNM的NM支持的NM肿瘤学家到初级保健的护理过渡项目Echotm。 CCP由Linda Cook，PhD（分子流行病学）和Shiraz Mishra，MBBS，博士领导（行为 /社区干预）。 CCP有来自6个部门的29名成员（24名完整，5名合伙人）医学院（内科，儿科，家庭和社区医学，病理学和皮肤病学）；人口卫生，药房以及艺术与科学学院（工程和地球系行星科学）；和Lovelace呼吸研究所。截至2020年9月1日，CCPS拥有1750万美元年度直接资金总数； 1,110万美元经过同行评审，250万美元来自NCI。此外，CCPS有270万美元在NCI的年度直接资金中，通过NCI SEER合同的新墨西哥肿瘤注册表和CCSG 补品。 CCP中的发现导致了336份出版物，其中24％是主要程序内合作，有20％是程序间合作，60％是与其他合作全国范围内的癌症中心和12％的癌症中心发表在高影响期刊上。 CCPS已进行了28次干预 1629次应计的研究。