Public Drinking Water Contaminants and Infant Health: Advancing Environmental Justice

公共饮用水污染物和婴儿健康：促进环境正义

• 批准号: 10488610
• 负责人: Anne E Nigra
• 金额: $ 40.5万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488610
• 关键词: American Indians; Arsenic; Automobile Driving; Award; Biological Markers; Birth; Birth Records; California; Case Study; Child Health; Cities; Collaborations; Communities; County; Data; Databases; Development; Disinfection; Dose; Environmental Health; Epidemiologist; Epidemiology; Ethnic Origin; Evidence based intervention; Exhibits; Exposure to; Funding; Gestational Age; Health; Hispanic; Imprisonment; Inequality; Infant; Infant Health; Journals; Lead; Link; Longevity; Low Birth Weight Infant; Maps; Measures; Metal exposure; Metals; Modeling; Monitor; Multiple Birth Offspring; Outcome; Participant; Peer Review; Plant Roots; Policies; Positioning Attribute; Pregnancy; Premature Birth; Productivity; Public Health Schools; Publications; Race; Radioisotopes; Reduce health disparities; Regulation; Research; Research Personnel; Small for Gestational Age Infant; Socioeconomic Status; Strategic Planning; Structural Racism; Subgroup; System; United States; United States Environmental Protection Agency; United States National Institutes of Health; Universities; Water; Water Pollutants; adverse birth outcomes; career; career development; classism; cohort; data repository; drinking water; effectiveness evaluation; environmental justice; epidemiology study; health disparity; improved; in utero; innovation; microbial; novel; prenatal exposure; primary outcome; professor; programs; public drinking; public health intervention; racial and ethnic; racial and ethnic disparities; racial disparity; racial diversity; recruit; rural Americans; secondary outcome; socioeconomic disparity; socioeconomics; tenure track; urinary

Project Summary The objective of this project is to evaluate the contribution of racial/ethnic and socioeconomic inequalities in public drinking water contaminant exposures to in utero water contaminant exposures and subsequent adverse birth outcomes across the United States (US). Potential disparities in public drinking water contaminant exposures have not been comprehensively characterized across the US. Such disparities in public drinking water contaminant exposures may directly contribute to inequalities in in utero exposures and inequalities in adverse birth outcomes. This proposal aims to (1) evaluate racial/ethnic and socioeconomic inequalities in drinking water contaminant exposures across the US by developing novel nationwide public drinking water contaminant exposure estimates for over eighty regulated contaminants; (2) evaluate the contribution of estimated public drinking water metal exposures to measured in utero internal dose and infant health outcomes across three diverse birth cohorts; and (3) evaluate the impact of changes in national public drinking water regulations on infant health outcomes using a difference-in-differences approach, which can characterize the impact of federal drinking water regulatory changes on diverse racial/ethnic and socioeconomic subgroups in the US. In Aim 1, novel nationwide public drinking water contaminant exposure estimates will be derived primarily using data from the US Environmental Protection Agency's Six Year Review of Contaminant Occurrence database, which contains compliance monitoring data for over 95% of public drinking water systems throughout the US. In Aim 2, novel public drinking water contaminant exposure estimates from Aim 1 are assigned to maternal-infant dyads in several diverse birth cohorts in the Environmental influences on Child Health Outcomes (ECHO) nationwide consortium, a pioneering NIH funded consortium. In Aim 3, novel public drinking water contaminant exposure estimates from Aim 1 are assigned to birth records from the California Comprehensive Birth File to evaluate the impact of reducing water contaminant exposures (via federal regulatory change) on adverse birth outcomes. The proposed study responds directly to the NIH Strategic Plan 2020 aim to “Develop evidence- based interventions to reduce health disparities,” including “Understanding mechanisms that lead to health disparities by race/ethnicity and socioeconomic status.”

项目摘要 该项目的目的是评估种族/种族和社会经济不平等的贡献 公共饮用水污染物暴露于子宫内水污染物的暴露和随后的敌人 美国（美国）的出生结果。公共饮用水污染物中的潜在分布 在美国，尚未全面表征暴露。公共饮酒的差异 水污染物的暴露可能直接导致子宫内暴露和不平等的不平等现象 不利的出生结果。 该建议旨在（1）评估饮用水污染物的种族/种族和社会经济不平等现象 通过开发全国性的全国公共饮用水污染物暴露，在美国各地的暴露 估计超过80种受调节污染物的估计； （2）评估估计的公共饮酒的贡献 在三个潜水员的子宫内剂量和婴儿健康结果中测量的水金属暴露 出生队列； （3）评估国家公共饮用水法规变化对婴儿的影响 使用差异差异方法的健康成果，可以表征联邦的影响 美国对潜水员种族/种族和社会经济亚组的饮用水调节变化。在AIM 1中， 全国性的全国公共饮用水污染物暴露估算将主要使用数据得出 来自美国环境保护局对污染物发生数据库的六年审查， 包含全美国95％以上公共饮用水系统的合规性监视数据。目标 2，AIM 1的新型公共饮用水污染物暴露估计已分配给母婴 环境影响儿童健康结果的几个潜水员出生队列中的二元组（ECHO） 全国联盟，一家开拓性的NIH资助的财团。在AIM 3中，新颖的公共饮用水污染物 AIM 1的暴露估计分配给加利福尼亚综合出生档案的出生记录 评估减少水污染物暴露（通过联邦监管变更）对不良出生的影响 结果。拟议的研究直接回应了2020年NIH战略计划的旨在“发展证据 - 基于减少健康分布的干预措施，包括“了解导致健康的机制 种族/种族和社会经济地位的差异。”