Enhancing Children's Cognitive Function and Achievement through Carotenoid Consumption

通过摄入类胡萝卜素增强儿童的认知功能和成绩

• 批准号: 10488167
• 负责人: Naiman Khan
• 金额: $ 56.65万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488167
• 关键词: 10 year old; Academic achievement; Achievement; Antioxidants; Attention; Brain; Carotenoids; Child; Child Nutrition; Childhood; Cognition; Cognitive; Collaborations; Consumption; Control Groups; Data; Data Set; Diet; Dietary Carotenoid; Dietary Practices; Double-Blind Method; Event; Exhibits; Eye; Food; Health; Health Promotion; Hippocampus (Brain); Human; Intake; Intervention; Isomerism; Knowledge; Laboratories; Learning; Link; Longevity; Lutein; Measures; Mediating; Membrane; Memory; Mission; Neuraxis; Neurocognitive; Nutrient; Nutritional; Optics; Outcome; Parents; Pattern; Performance; Pigments; Placebo Control; Plants; Policy Maker; Positioning Attribute; Publishing; Randomized; Reaction Time; Recommendation; Recording of previous events; Research; Resource Allocation; Retina; Role; Schools; Supplementation; Surrogate Markers; Task Performances; Testing; Time; Tissues; United States; United States National Institutes of Health; Vegetables; Waiting Lists; Work; cognitive benefits; cognitive control; cognitive development; cognitive function; density; design; dietary guidelines; double-blind placebo controlled trial; evidence base; evidence based guidelines; executive function; improved; indexing; information processing; innovation; insight; learning ability; macula; novel; nutrition; nutritional approach; placebo group; preadolescence; primary outcome; processing speed; reconstruction; relating to nervous system; relational memory; secondary outcome; success; teacher; zeaxanthin

Project Abstract Adequate diet quality has the potential to promote childhood cognitive health and have a lasting impact on children’s ability for learning and achievement. My laboratory has identified that lutein, a plant pigment or carotenoid found in rich quantities in dark green vegetables, is uniquely suitable for supporting childhood cognition and achievement. Lutein is the predominant carotenoid in neural tissue, serving roles as an antioxidant across neural membranes. Further, lutein, along with two other carotenoids (i.e., zeaxanthin and mesozeaxanthin) accumulate in the macular as macular pigment, which is known to strongly correlate with brain lutein. My work has linked macular pigment optical density (MPOD) – a noninvasive measure of retinal and brain lutein – to greater childhood cognitive function. However, the cognitive implications of lutein and zeaxanthin intake in children have not been directly investigated. This proposal aims to establish a causal relationship between lutein intake, cognitive function, and academic performance. The central hypothesis is that lutein consumption will benefit cognitive function and academic achievement in preadolescents. I also anticipate that gains in cognitive outcomes will be mediated by the improvement in MPOD. These hypotheses will be tested by conducting a randomized placebo-controlled double-blind trial to examine the effects of 9-month carotenoid supplementation on MPOD, cognition (attention and memory), and achievement among 8-10-year-old children (N=288, 144/group). The active supplement will comprise of 10mg lutein + 2mg zeaxanthin. This work will provide the evidence-base for recommendations to improve dietary practices for optimal childhood cognitive function and achievement. The proposed research is relevant to human health and the NIH mission because it will provide novel data supporting evidence-based recommendations to improve dietary practices for optimal cognitive function and achievement in childhood.

项目摘要 充足的饮食质量有可能促进儿童认知健​​康并对儿童产生持久影响 我的实验室发现叶黄素（一种植物色素）可以提高儿童的学习能力和成就。 深绿色蔬菜中含有丰富的类胡萝卜素，特别适合支持儿童 叶黄素是神经组织中主要的类胡萝卜素，具有抗氧化剂的作用。 此外，叶黄素以及其他两种类胡萝卜素（即玉米黄质和 中玉米黄质）作为黄斑色素积聚在黄斑中，已知与大脑密切相关 我的工作将黄斑色素光密度（MPOD）联系起来——一种视网膜和大脑的无创测量方法。 叶黄素——增强儿童认知功能然而，叶黄素和玉米黄质对认知的影响。 该提案旨在建立因果关系。 叶黄素摄入量、认知功能和学习成绩之间的关系的中心假设是叶黄素。 我还预计，消费将有利于青春期前儿童的认知功能和学业成绩。 认知结果的改善将通过 MPOD 的改善来调节。这些假设将通过以下方法进行检验。 进行一项随机安慰剂对照双盲试验，以检验 9 个月类胡萝卜素的效果 8-10岁儿童MPOD、认知（注意力和记忆力）和成绩的补充 （N=288，144/组）这项工作将提供 10 毫克叶黄素 + 2 毫克玉米黄质。 改善饮食习惯以实现最佳儿童认知功能的建议的证据基础 拟议的研究与人类健康和 NIH 的使命相关，因为它将提供 新数据支持基于证据的建议，以改善饮食习惯，实现最佳饮食习惯 童年时期的功能和成就。