Enhancing Children's Cognitive Function and Achievement through Carotenoid Consumption

通过摄入类胡萝卜素增强儿童的认知功能和成绩

• 批准号: 10488167
• 负责人: Naiman Khan
• 金额: $ 56.65万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488167
• 关键词: 10 year old; Academic achievement; Achievement; Antioxidants; Attention; Brain; Carotenoids; Child; Child Nutrition; Childhood; Cognition; Cognitive; Collaborations; Consumption; Control Groups; Data; Data Set; Diet; Dietary Carotenoid; Dietary Practices; Double-Blind Method; Event; Exhibits; Eye; Food; Health; Health Promotion; Hippocampus (Brain); Human; Intake; Intervention; Isomerism; Knowledge; Laboratories; Learning; Link; Longevity; Lutein; Measures; Mediating; Membrane; Memory; Mission; Neuraxis; Neurocognitive; Nutrient; Nutritional; Optics; Outcome; Parents; Pattern; Performance; Pigments; Placebo Control; Plants; Policy Maker; Positioning Attribute; Publishing; Randomized; Reaction Time; Recommendation; Recording of previous events; Research; Resource Allocation; Retina; Role; Schools; Supplementation; Surrogate Markers; Task Performances; Testing; Time; Tissues; United States; United States National Institutes of Health; Vegetables; Waiting Lists; Work; cognitive benefits; cognitive control; cognitive development; cognitive function; density; design; dietary guidelines; double-blind placebo controlled trial; evidence base; evidence based guidelines; executive function; improved; indexing; information processing; innovation; insight; learning ability; macula; novel; nutrition; nutritional approach; placebo group; preadolescence; primary outcome; processing speed; reconstruction; relating to nervous system; relational memory; secondary outcome; success; teacher; zeaxanthin

Project Abstract Adequate diet quality has the potential to promote childhood cognitive health and have a lasting impact on children’s ability for learning and achievement. My laboratory has identified that lutein, a plant pigment or carotenoid found in rich quantities in dark green vegetables, is uniquely suitable for supporting childhood cognition and achievement. Lutein is the predominant carotenoid in neural tissue, serving roles as an antioxidant across neural membranes. Further, lutein, along with two other carotenoids (i.e., zeaxanthin and mesozeaxanthin) accumulate in the macular as macular pigment, which is known to strongly correlate with brain lutein. My work has linked macular pigment optical density (MPOD) – a noninvasive measure of retinal and brain lutein – to greater childhood cognitive function. However, the cognitive implications of lutein and zeaxanthin intake in children have not been directly investigated. This proposal aims to establish a causal relationship between lutein intake, cognitive function, and academic performance. The central hypothesis is that lutein consumption will benefit cognitive function and academic achievement in preadolescents. I also anticipate that gains in cognitive outcomes will be mediated by the improvement in MPOD. These hypotheses will be tested by conducting a randomized placebo-controlled double-blind trial to examine the effects of 9-month carotenoid supplementation on MPOD, cognition (attention and memory), and achievement among 8-10-year-old children (N=288, 144/group). The active supplement will comprise of 10mg lutein + 2mg zeaxanthin. This work will provide the evidence-base for recommendations to improve dietary practices for optimal childhood cognitive function and achievement. The proposed research is relevant to human health and the NIH mission because it will provide novel data supporting evidence-based recommendations to improve dietary practices for optimal cognitive function and achievement in childhood.

项目摘要 足够的饮食质量有可能促进儿童认知健​​康，并对 孩子们的学习和成就能力。我的实验室已经确定叶黄素，植物色素或 类胡萝卜素在深绿色的蔬菜中以丰富的数量发现，非常适合支撑童年 认知和成就。黄体蛋白是神经元组织中主要的类胡萝卜素，作为抗氧化剂的作用 跨神经膜。此外，叶黄素以及另外两个类胡萝卜素（即玉米黄质和 中佐糖蛋白）积聚在黄斑中，作为黄斑色素，已知与脑密切相关 叶黄素。我的工作已经连接了黄斑色素光密度（MPOD） - 残留和大脑的无创测量 叶黄素 - 更大的童年认知功能。但是，叶黄素和玉米黄质的认知含义 尚未直接调查儿童的摄入量。该建议旨在建立因果关系 在叶黄素摄入量，认知功能和学习成绩之间。中心假设是叶黄素 消费将有益于前占领的认知功能和学术成就。我也期待 MPOD的改善将介导认知结果的收益。这些假设将通过 进行一项随机安慰剂对照的双盲试验，以检查9个月类胡萝卜素的影响 在8-10岁的孩子中补充MPOD，认知（注意力和记忆）以及成就 （n = 288，144/组）。活性补充剂将完成10mg叶黄素 + 2mg Zeaxanthin。这项工作将提供 建议改善饮食习惯的建议基础，以获得最佳儿童认知功能 和成就。拟议的研究与人类健康和NIH任务有关，因为它将提供 新的数据支持基于证据的建议，以改善最佳认知饮食实践 童年的功能和成就。