EnamExcel: Iteratively develop the world's first varnish that regenerates and regrows human enamel and transforms global oral health.

EnamExcel：迭代开发世界上第一个能够再生和再生人类牙釉质并改变全球口腔健康的清漆。

• 批准号: 10094179
• 金额: $ 41.7万
• 依托单位: MINTECH-BIO LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10094179
• 关键词: EnamExcel; Iteratively; develop; world; first

Globally, poor oral health and oral diseases are costing £450B and affecting over 3.5B people. Enamel erosion is a major contributor to these conditions, affecting almost 50% of the world's population. Evidence suggests that poor oral health may also be linked to non-communicable diseases such as diabetes, cardiovascular complications, and pneumonia.However, current treatments such as fluoride varnishes and remineralisation solutions only alleviate the symptoms of receding enamel. There is currently no solution available that can effectively re-grow enamel with non-toxic compounds that are easy to use and produce comparable structures and mechanical properties in a patient-friendly manner.Mintech has developed a patent-pending compound and process to create a topical varnish for teeth that can regrow enamel. This breakthrough innovation has the potential to replace preventative fluoride varnishes, regenerate eroded dental enamel, and significantly reduce the global burden of oral health diseases. To achieve this goal, this grant proposal aims to bring Mintech's current prototype into a market-ready state and prepare it for commercialisation. With the successful implementation of this project, Mintech's enamel-regenerating varnish could revolutionise oral healthcare and improve the quality of life for millions of people worldwide.

在全球范围内，不良的口腔健康和口腔疾病造成了 450B 英镑的损失，影响了超过 3.5B 人。牙釉质侵蚀是造成这些疾病的主要原因，影响了世界上近 50% 的人口。有证据表明，不良的口腔健康也可能与口腔不良有关。 - 糖尿病、心血管并发症和肺炎等传染病。然而，目前的治疗方法（例如氟化物清漆和再矿​​化溶液）只能缓解牙釉质退缩的症状，目前还没有可用的解决方案。可以使用无毒化合物有效地重新生长牙釉质，这些化合物易于使用，并以对患者友好的方式产生可比的结构和机械性能。Mintech 开发了一种正在申请专利的化合物和工艺，用于制造可再生牙齿的局部清漆这项突破性创新有可能取代预防性氟化物清漆，使受侵蚀的牙釉质再生，并显着减轻全球口腔健康疾病的负担。为了实现这一目标，这项拨款提案旨在实现这一目标。 Mintech 目前的原型已进入市场准备阶段，并为商业化做好准备。随着该项目的成功实施，Mintech 的牙釉质再生清漆将彻底改变口腔保健并改善全球数百万人的生活质量。