Contaminants of emerging concern: An integrated approach for assessing impacts on the marine environment. Acronym: CONTRAST

新出现的污染物：评估对海洋环境影响的综合方法。

• 批准号: 10093180
• 金额: $ 22.73万
• 依托单位: SHIRE CREATIVE LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10093180
• 关键词: Contaminants; emerging; concern; integrated; approach

CONTRAST will develop an integrated assessment and effect-based monitoring framework (IAF) to measure the impacts of CECs on the marine environment to provide a measure of Good Environmental Status for application in EU policy (i.e. MSFD/WFD). The IAF will involve chemical measurements together with biological effects endpoints that will be optimised to detect the presence and degree of effect of CECs in the marine environment. CONTRAST will identify the CECs that pose the greatest threat to marine life by using chemical prioritisation schemes to inform which of the CECs should be measured in the environment. Additionally, which CECs should be used in the laboratory-controlled experiments, where the effects on biological systems and marine biodiversity will be performed. A combination of in silico, in vitro and in vivo bioassays together with omics will be used to determine the principal mechanisms of toxicity of CECs selected from the chemical prioritisation schemes. This will provide important information on how CECs may interact with marine organisms at environmentally relevant concentrations and inform which biological effects tools should be used in the IAF to cover the range of toxicity mechanisms that CECs produce. CONTRAST will address this by optimising existing and developing new biomarkers, so that the IAF includes biomarker tools to cover many of the mechanism of toxicity produced by CECs. A series of European wide case studies will be used to test the suitability of the IAF to measure the effects of chemicals including CECs on indicator species and biodiversity. The knowledge gained from field testing and laboratory studies will form the basis for guidance documents and policy briefs on the best practices for performing an IAF on CECs in the marine environment. Furthermore, the interactions of climate change drivers on CECs will be evaluated including effects on CECs distribution, circulation, fate, bioavailability, and toxicity to marine life

CONTRAST 将制定综合评估和基于效果的监测框架 (IAF)，以衡量 CEC 对海洋环境的影响，从而为欧盟政策中的应用提供良好环境状况的衡量标准（即 MSFD/WFD）。 IAF 将涉及化学测量和生物效应终点，这些终点将被优化以检测海洋环境中 CEC 的存在和影响程度。 CONTRAST 将通过使用化学优先方案确定对海洋生物构成最大威胁的 CEC，以告知应在环境中测量哪些 CEC。此外，应在实验室控制实验中使用哪些 CEC，以研究对生物系统和海洋生物多样性的影响。将使用计算机、体外和体内生物测定与组学相结合来确定从化学优先方案中选择的 CEC 的主要毒性机制。这将提供有关 CEC 如何在环境相关浓度下与海洋生物相互作用的重要信息，并告知 IAF 中应使用哪些生物效应工具来涵盖 CEC 产生的一系列毒性机制。 CONTRAST 将通过优化现有的和开发新的生物标志物来解决这个问题，以便 IAF 包括生物标志物工具来涵盖 CEC 产生的许多毒性机制。将使用一系列欧洲范围内的案例研究来测试 IAF 是否适合测量包括 CEC 在内的化学品对指示物种和生物多样性的影响。从现场测试和实验室研究中获得的知识将构成关于在海洋环境中对 CEC 进行 IAF 最佳实践的指导文件和政策简介的基础。此外，还将评估气候变化驱动因素对 CEC 的相互作用，包括对 CEC 分布、循环、归宿、生物利用度和对海洋生物的毒性的影响