Contaminants of emerging concern: An integrated approach for assessing impacts on the marine environment. Acronym: CONTRAST

新出现的污染物：评估对海洋环境影响的综合方法。

• 批准号: 10093180
• 金额: $ 22.73万
• 依托单位: SHIRE CREATIVE LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10093180
• 关键词: Contaminants; emerging; concern; integrated; approach

CONTRAST will develop an integrated assessment and effect-based monitoring framework (IAF) to measure the impacts of CECs on the marine environment to provide a measure of Good Environmental Status for application in EU policy (i.e. MSFD/WFD). The IAF will involve chemical measurements together with biological effects endpoints that will be optimised to detect the presence and degree of effect of CECs in the marine environment. CONTRAST will identify the CECs that pose the greatest threat to marine life by using chemical prioritisation schemes to inform which of the CECs should be measured in the environment. Additionally, which CECs should be used in the laboratory-controlled experiments, where the effects on biological systems and marine biodiversity will be performed. A combination of in silico, in vitro and in vivo bioassays together with omics will be used to determine the principal mechanisms of toxicity of CECs selected from the chemical prioritisation schemes. This will provide important information on how CECs may interact with marine organisms at environmentally relevant concentrations and inform which biological effects tools should be used in the IAF to cover the range of toxicity mechanisms that CECs produce. CONTRAST will address this by optimising existing and developing new biomarkers, so that the IAF includes biomarker tools to cover many of the mechanism of toxicity produced by CECs. A series of European wide case studies will be used to test the suitability of the IAF to measure the effects of chemicals including CECs on indicator species and biodiversity. The knowledge gained from field testing and laboratory studies will form the basis for guidance documents and policy briefs on the best practices for performing an IAF on CECs in the marine environment. Furthermore, the interactions of climate change drivers on CECs will be evaluated including effects on CECs distribution, circulation, fate, bioavailability, and toxicity to marine life

对比度将开发一个综合评估和基于效果的监测框架（IAF），以衡量CEC对海洋环境的影响，以衡量欧盟政策中应用良好的环境状况（即MSFD/WFD）。 IAF将涉及化学测量以及生物效应端点，这些终点将被优化，以检测CEC在海洋环境中的存在和程度。对比度将通过使用化学优先级方案告知应在环境中测量哪些CEC来确定对海洋生物构成最大威胁的CEC。此外，应在实验室控制的实验中使用哪些CEC，其中将对生物系统和海洋生物多样性进行影响。硅，体外和体内生物测定以及OMICS的组合将用于确定从化学优先计算方案中选择的CEC毒性的主要机制。这将提供有关CEC如何以环境相关浓度与海洋生物相互作用的重要信息，并告知应在IAF中使用哪些生物效应工具来涵盖CEC产生的毒性机制范围。对比度将通过优化现有和开发新的生物标志物来解决这一问题，以便IAF包括生物标志物工具，以涵盖CEC产生的许多毒性机制。一系列欧洲范围的案例研究将用于测试IAF的适用性，以测量包括CEC对指标物种和生物多样性（包括CEC）的影响。从现场测试和实验室研究中获得的知识将构成有关指导文件和政策简介的基础，以了解海洋环境中对CEC进行IAF的最佳实践。此外，将评估气候变化驱动因素在CEC上的相互作用，包括对CEC分布，循环，命运，生物利用度和对海洋生物的毒性的影响