Dye-free, on-demand visualization of blood flow during cerebrovascular surgery

脑血管手术期间血流的无染料、按需可视化

基本信息

批准号：
10483677
负责人：
Abhishek Rege
金额：
$ 73.03万
依托单位：
VASOPTIC MEDICAL, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10483677
关键词：
Anastomosis - action Aneurysm Angiography Animal Model Animals Arteriovenous malformation Blood Blood Circulation Blood Flow Velocity Blood Vessels Blood flow Brain Brain Aneurysms Brain region Bypass Caliber Cauterize Cerebrovascular system Clinical Clip Complex Computer software Contrast Media Data Decision Making Dyes Equipment Evaluation Excision Extravasation Feedback Goals Hemorrhage Image Imaging technology Indocyanine Green Intervention Intravenous Laser Speckle Imaging Letters Logistics Manufacturer Name Measurement Methods Microscope Monitor Moyamoya Disease Neurosurgeon Operating Rooms Operative Surgical Procedures Optics Oryctolagus cuniculus Performance Perfusion Phase Postoperative Period Procedures Public Health Rattus Readiness Reperfusion Therapy Resolution Safety Sheep Sterilization Surgeon Surgical Models System Techniques Technology Testing Time Tissue Viability Tissues Validation Variant Vascular blood supply Visual Fields Visualization anterior cerebral artery base blood flow measurement blood perfusion brain surgery cerebrovascular cerebrovascular surgery clinical imaging commercialization cranium data visualization first-in-human imaging system interest middle cerebral artery multiple datasets neurosurgery novel optical imaging post intervention preclinical imaging preservation prevent prototype revascularization surgery success usability

Anastomosis - action Aneurysm Angiography Animal Model Animals Arteriovenous malformation Blood Blood Circulation Blood Flow Velocity Blood Vessels Blood flow Brain Brain Aneurysms Brain region Bypass Caliber Cauterize Cerebrovascular system Clinical Clip Complex Computer software Contrast Media Data Decision Making Dyes Equipment Evaluation Excision Extravasation Feedback Goals Hemorrhage Image Imaging technology Indocyanine Green Intervention Intravenous Laser Speckle Imaging Letters Logistics Manufacturer Name Measurement Methods Microscope Monitor Moyamoya Disease Neurosurgeon Operating Rooms Operative Surgical Procedures Optics Oryctolagus cuniculus Performance Perfusion Phase Postoperative Period Procedures Public Health Rattus Readiness Reperfusion Therapy Resolution Safety Sheep Sterilization Surgeon Surgical Models System Techniques Technology Testing Time Tissue Viability Tissues Validation Variant Vascular blood supply Visual Fields Visualization anterior cerebral artery base blood flow measurement blood perfusion brain surgery cerebrovascular cerebrovascular surgery clinical imaging commercialization cranium data visualization first-in-human imaging system interest middle cerebral artery multiple datasets neurosurgery novel optical imaging post intervention preclinical imaging preservation prevent prototype revascularization surgery success usability

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项目摘要

ABSTRACT Cerebrovascular surgeons performing delicate surgeries such as aneurysm clipping, arteriovenous malformation resections, or revascularization procedures could benefit if quantitative information pertaining to the blood flow status of vessels in their surgical field was made available to them. Current technologies that can monitor blood flow at high resolution either use complex dedicated equipment or rely on administration of contrast agents, both of which are disruptive to the surgical procedure and hence, undesired. Dye-based techniques like ICG video- angiography may not be used frequently and often used only for post-surgical confirmation of surgical success. We propose a novel method that can noninvasively provide real-time information about blood flow in the neurosurgeon’s field of view at the spatial scale of microvessels. This modular optical imaging system (called the CVSurgeONTM) will integrate with existing neurosurgical microscopes in operating rooms providing the neurosurgeon-user an on-demand video feed of blood flow information to assist in surgical decision-making. This complementary blood flow information will be obtained using proprietary and licensed laser speckle contrast imaging technology, and optionally presented to the neurosurgeon in his/her visual field overlaid on the region of interest. We have previously built a prototype of the system and validated its function in small and large animal models of reversible and irreversible occlusion of vessels in the brain. Our proposed Phase II project aims to adapt our technology for clinical use in neurosurgery and then conduct first-in-human studies to validate the system performance and usefulness in three important types of cerebrovascular surgeries – aneurysm clipping, cauterization of arteriovenous malformations, and cerebrovascular bypass surgery for moyamoya disease.

抽象的脑血管外科医师进行精致的手术，例如动脉瘤，动脉畸形如果与血流有关的定量信息，切除或血运重建程序可能会受益他们的手术领域的船只状况已为他们提供。当前可以监测血液的技术高分辨率以使用复杂的专用设备或依赖对比剂的给药，两者都以高分辨率流动其中对外科手术是破坏性的，因此是不希望的。诸如ICG视频之类的基于染料的技术 - 血管造影可能不会经常使用，并且通常仅用于手术后的手术成功证实。我们提出了一种新颖的方法，可以非侵入性地提供有关血流的实时信息神经外科医生的视野在微血管的空间规模上。这个模块化光学成像系统（计算） CVSurgeontm）将与手术室中现有的神经外科显微镜集成神经外科用户 - 按需视频供稿血流信息，以帮助进行手术决策。该完整的血流信息将使用专有和许可的激光斑点对比度获得成像技术，可选地呈现在他/她的视野中覆盖在该地区的神经外科医生感兴趣的。我们以前已经建立了系统的原型，并在大小动物中验证了其功能大脑中血管的可逆和不可逆遮挡模型。我们提议的第二阶段项目旨在适应我们的技术用于神经外科手术，然后进行首次人类研究以验证在三种重要类型的脑血管手术中的系统性能和实用性 - 动脉瘤剪切，动静脉畸形的烧灼和蒙太太亚病的脑血管旁路手术。