Wireless Implantable Mechano-Acoustic Recording Device

无线植入式机械声记录设备

基本信息

批准号：
10484423
负责人：
Cameron Good
金额：
$ 25.96万
依托单位：
NEUROLUX, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-22 至 2023-09-21
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10484423
关键词：
3-Dimensional Accelerometer Acoustics Adult Anesthesia procedures Animal Behavior Animal Model Animals Arousal Behavior Behavioral Benchmarking Bluetooth Chronic Communities Complex Computer software Consumption Coupled Data Data Collection Development Devices Disease Drug Delivery Systems Environment Future General Anesthesia Harvest Heart Heart Rate Implant Individual Infrastructure Investigation Laboratories Libraries Location Locomotion Measurement Mediating Methods Monitor Motion Mus Muscle Neurons Neurosciences Neurosciences Research Noise Operative Surgical Procedures Performance Peripheral Phase Physiological Physiology Preparation Procedures Pulse Oximetry Rattus Reader Reading Records Recovery Research Resolution Respiration Rodent Signal Transduction Small Business Innovation Research Grant Social Behavior Social Environment Social Interaction System Technology Temperature Testing Time Translations Universities Validation Washington Work awake base behavior test cost data acquisition data exchange design effective therapy experimental study in vivo in vivo evaluation machine vision miniaturize minimally invasive monitoring device neuropsychiatric disorder new technology novel strategies operation optogenetics pre-clinical programs pup radio frequency relating to nervous system respiratory response signal processing social social factors social group subcutaneous technology development technology validation time use tool vibration wireless wireless electronic

项目摘要

PROJECT SUMMARY - ABSTRACT We will design a fully implantable, wireless, battery-free, Mechano-Acoustic (MA) device that allows for multi- parameter physiological data acquisition from freely moving small animal models, via use of high bandwidth triaxial accelerometers. The proposed technology records relevant vital sign information such as the heart and respiration rate and temperature, and other general features about the animal that include locomotion and body orientation. Each of these features are determined in parallel from subtle motions detected with this platform using the most advanced inertial measurement unit (IMU) technology and transmitted wirelessly and analyzed in real-time using Bluetooth Low Energy (BLE) 5.2 to an external reader system – all isolated to individual subjects within experimental contexts spanning single to multi-animal behaviors. This approach allows other experimental approaches (video tracking, neural recording, closed-loop optogenetics, etc.) to be directly coupled to the recorded physiological data. Integration of a BLE 5.2 reading board into the existing NeuroLux Power Distribution Control (PDC) box will enable simultaneous use with other devices in NeuroLux’s product portfolio, including fully implantable optogenetic devices and wireless drug-delivery systems that are currently in widespread use across various parts of the neuroscience community. By delivering both power and data wirelessly, and by entirely eliminating all external fixtures and physical tethers on the animal, the proposed technology enables chronic physiological recordings in three-dimensional naturalistic environments, from isolated individuals or social groups, in ways that are fundamentally impossible with conventional hardware infrastructure. This low-cost manufacturable system is fully compatible with the NeuroLux radio frequency wireless electronic platform and control software, allowing us to leverage the strengths of an existing commercial platform currently in use in >150 laboratories worldwide to further advance neuroscience research capabilities.

项目摘要 - 摘要我们将设计一种完全植入式、无线、无电池、机械声学 (MA) 设备，允许多种通过使用高带宽，从自由移动的小动物模型中采集参数生理数据所提出的技术记录相关的生命体征信息，例如心脏和心脏。呼吸速率和温度，以及动物的其他一般特征，包括运动和身体这些特征中的每一个都是根据该平台检测到的细微运动并行确定的。采用最先进的惯性测量单元（IMU）技术并无线传输和分析使用蓝牙低功耗 (BLE) 5.2 实时连接到外部读卡器系统 – 全部与个人隔离这种方法允许在涵盖单一到多种动物行为的实验环境中进行受试者。直接耦合的实验方法（视频跟踪、神经记录、闭环光遗传学等）将 BLE 5.2 读取板集成到现有 NeuroLux Power 中。配电控制（PDC）盒将能够与 NeuroLux 产品组合中的其他设备同时使用，包括目前正在研发的完全植入式光遗传学设备和无线药物输送系统通过提供电力和数据，在神经科学界的各个领域得到广泛使用。通过无线方式，并完全消除动物身上的所有外部固定装置和物理绳索，拟议的技术可以在三维自然环境中进行慢性生理记录，从以传统硬件根本不可能实现的方式隔离个人或社会群体这种低成本的可制造系统与 NeuroLux 射频完全兼容。无线电子平台和控制软件，使我们能够利用现有商业的优势该平台目前在全球超过 150 个实验室中使用，以进一步提高神经科学研究能力。