Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort

创新基础设施，以增强和维持加州教师研究队伍

• 批准号: 10478112
• 负责人: James V Lacey
• 金额: $ 102.45万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478112
• 关键词: Achievement; Address; Age; Aging; Air Pollution; Aliquot; Area; Authorization documentation; Award; Biological Markers; Blood specimen; California; Cessation of life; Characteristics; Clinical; Cloud Computing; Cohort Studies; Collaborations; Collection; Communities; Complement; Complex; Data; Data Analyses; Data Collection; Data Commons; Data Mart; Emergency department visit; Ensure; Environment; Environment Design; Environmental Exposure; Epidemiology; Essential worker; Etiology; FAIR principles; Female; Follow-Up Studies; Foundations; Future; Goals; Green space; Health; Health Planning; Health Services; Health Services Research; Hospitalization; Individual; Infrastructure; Inpatients; Light; Link; Longitudinal Studies; Maintenance; Malignant Neoplasms; Manuals; Medicare; Medicare claim; Metadata; Modernization; Outcome; Outpatients; Participant; Phase; Positioning Attribute; Process; Protocol Compliance; Public Health; Reporting; Reproducibility; Request for Proposals; Research; Research Personnel; Resources; Sampling; Sampling Studies; Secure; Services; Shipping; Solid; Specimen; Surveys; Time; UV Radiation Exposure; Update; Visualization software; Vital Status; anticancer research; application programming interface; base; built environment; cancer epidemiology; cancer risk; cancer therapy; climate data; cloud based; cohort; comorbidity; data modeling; data resource; data sharing; data visualization; data warehouse; disorder risk; eligible participant; extreme weather; flexibility; follow-up; handheld mobile device; health care service utilization; high risk; human old age (65+); innovation; mortality; neoplasm registry; operation; patient engagement; phenotypic data; preservation; prospective; research study; resilience; social; social vulnerability; survivorship; teacher; volunteer; vulnerable community

PROJECT SUMMARY / ABSTRACT The California Teachers Study (CTS) has collected high-quality and detailed exposure, biospecimens, cancer, and clinical endpoint data on 133,477 female volunteers followed since 1995. The cancers, hospitalizations, and deaths to date are less than half of the total endpoints projected to occur in the CTS over the next 30 years. In the next 5 years, CTS follow-up will include over 37,000 cancers; 455,000 hospitalizations; and 41,000 deaths. This provides a solid foundation for collaborative research using these unique resources. Since 2013, the CTS collected new blood samples from 14,674 participants. Cloud computing and integrated mobile devices generated rich phenotype data and exceptionally low pre-analytical variability for 488,000 aliquots that are being stored as CTS follow-up continues. Since 2015, the CTS modernized its data collection, storage, and analysis infrastructure by implementing a secure data warehouse and flexible analytics environment designed for high-quality and integrated epidemiologic analysis. The CTS includes secure user authentication & authorization; a collaborative workspace with documents, data visualizations, tools, and workflows; metadata; application programming interface (API) capabilities; and a scalable data model. The CTS is now positioned to streamline its resources for long-term sustainability. The goals of this competing renewal are to preserve existing resources that enable research and strategically expand areas that create high-value opportunities. First, we will maintain existing CTS data and extend passive follow-up through efficient cancer, hospitalization, and mortality linkages. These ongoing linkages will generate additional endpoints used for future etiologic, consortial, aging, and other research. Second, we will store the 488,000 high-quality biospecimens collected since 2013. These specimens are all currently available to everyone; ongoing storage will ensure that they remain available to everyone. Third, we will expand capacity by integrating additional targeted geospatial data on climate, extreme weather, built environment, community characteristics, health access, environmental exposures, social vulnerability, and community resilience. The new CTS infrastructure efficiently enables everyone, regardless of their GIS expertise, to rigorously incorporate individual-level geospatial exposures into their analyses. Fourth, because most participants are now over age 65, we will link the CTS with Medicare outpatient data to complement existing data and expand infrastructure for aging, survivorship, comorbidity, and health services research. The recent CTS infrastructure updates added research-ready efficiencies to manage and process complex geospatial, administrative claims, and other CTS data in ways that help all researchers, especially those outside the CTS, conduct integrative, rigorous, and reproducible research. The CTS is an innovation leader with primed assets and decades of promising future research potential. This competing renewal will maintain high-value CTS resources that can address understudied research areas, facilitate broader use by the entire scientific community, and streamline the CTS for long-term sustainability.

项目摘要 /摘要 加利福尼亚教师研究（CTS）已收集了高质量和详细的接触，生物测量，癌症， 以及1995年以来133,477名女性志愿者的临床终点数据。癌症，住院治疗， 迄今为止的死亡不到预计在接下来30次CTS中预计发生的总终点的一半 年。在接下来的5年中，CTS随访将包括37,000多个癌症； 455,000次住院；和 41,000人死亡。这为使用这些独特资源的协作研究奠定了坚实的基础。自从 2013年，CTS收集了14,674名参与者的新血液样本。云计算和集成的手机 设备生成了丰富的表型数据和488,000个等分试样的分析前变异性极低 随着CTS随访的继续，正在存储。自2015年以来，CTS现代化了其数据收集，存储和 通过实施安全的数据仓库和灵活的分析环境，分析基础架构设计 用于高质量和综合流行病学分析。 CTS包括安全的用户身份验证＆ 授权;与文档，数据可视化，工具和工作流程的协作工作空间；元数据； 应用程序编程接口（API）功能；和可扩展的数据模型。 CTS现在位于 简化其资源以实现长期可持续性。这种竞争更新的目标是保存 现有资源，使研究并在战略上扩大创造高价值机会的领域。 首先，我们将维护现有的CTS数据，并通过大型癌症，住院，扩展被动随访 和死亡率联系。这些持续的链接将产生用于未来病因的其他端点， 财团，衰老和其他研究。其次，我们将存储收集的488,000个高质量的生物测量 自2013年以来。这些标本目前都可供所有人使用；正在进行的存储将确保他们 仍然可以为每个人提供。第三，我们将通过集成其他有针对性的地理空间数据来扩大容量 关于气候，极端天气，建筑环境，社区特征，健康获取，环境 暴露，社会脆弱性和社区韧性。新的CTS基础架构有效启用 不管他们的GIS专业知识如何 他们的分析。第四，因为大多数参与者现在已经超过65岁，所以我们将与Medicare联系起来 门诊数据以补充现有数据并扩大衰老，生存，合并症和合并症的基础架构 卫生服务研究。最近的CTS基础架构更新添加了准备就绪的效率来管理 并以帮助所有研究人员的方式处理复杂的地理空间，行政主张和其他CTS数据 特别是在CT之外的人，进行综合，严格和可再现的研究。 CTS是 具有启动资产的创新领导者以及几十年来有希望的未来研究潜力。这个竞争 更新将维护高价值的CTS资源，以解决研究领域的研究领域，促进 整个科学界的更广泛使用，并简化CTS的长期可持续性。